STEMCELL Science News
@stemcellsciencenews.com
A complete resource for the latest discoveries in cell biology, from organoids to immunology. Brought to you by STEMCELL Technologies.
In an IL-10 knockout model, an intermittent ketogenic diet (IKD) improved intestinal barrier function and reshaped the gut #microbiota, suggesting protective effects of IKD in the IL-10 knockout colitis model.
📝 Learn more about the research: bit.ly/3NMcwEJ
📝 Learn more about the research: bit.ly/3NMcwEJ
January 16, 2026 at 11:08 PM
In an IL-10 knockout model, an intermittent ketogenic diet (IKD) improved intestinal barrier function and reshaped the gut #microbiota, suggesting protective effects of IKD in the IL-10 knockout colitis model.
📝 Learn more about the research: bit.ly/3NMcwEJ
📝 Learn more about the research: bit.ly/3NMcwEJ
Scientists investigated the central role of histone deacetylase 6 in #SCLC progression and its regulatory mechanisms to identify novel therapeutic strategies.
📚 Read the article to learn more: https://bit.ly/4qQlM9i
📚 Read the article to learn more: https://bit.ly/4qQlM9i
January 15, 2026 at 6:36 PM
Scientists investigated the central role of histone deacetylase 6 in #SCLC progression and its regulatory mechanisms to identify novel therapeutic strategies.
📚 Read the article to learn more: https://bit.ly/4qQlM9i
📚 Read the article to learn more: https://bit.ly/4qQlM9i
🧪 Researchers create an efficient combined anti-tumor lipid nanoparticle (LNP) delivery system.
They added DMG-PEG2000-FA to the four-component LNP system and used microfluidic technology to prepare FA-LNP with tumor-targeting groups.
👉 https://bit.ly/3Lrwi7W
They added DMG-PEG2000-FA to the four-component LNP system and used microfluidic technology to prepare FA-LNP with tumor-targeting groups.
👉 https://bit.ly/3Lrwi7W
January 15, 2026 at 5:05 PM
🧪 Researchers create an efficient combined anti-tumor lipid nanoparticle (LNP) delivery system.
They added DMG-PEG2000-FA to the four-component LNP system and used microfluidic technology to prepare FA-LNP with tumor-targeting groups.
👉 https://bit.ly/3Lrwi7W
They added DMG-PEG2000-FA to the four-component LNP system and used microfluidic technology to prepare FA-LNP with tumor-targeting groups.
👉 https://bit.ly/3Lrwi7W
Researchers define a pathogenic monocyte transcriptional state linking systemic immune dysfunction to persistent long #COVID disease.
#OpenAccess
🔓 Learn more: https://go.nature.com/49xKvbj
#OpenAccess
🔓 Learn more: https://go.nature.com/49xKvbj
January 14, 2026 at 11:53 PM
Researchers define a pathogenic monocyte transcriptional state linking systemic immune dysfunction to persistent long #COVID disease.
#OpenAccess
🔓 Learn more: https://go.nature.com/49xKvbj
#OpenAccess
🔓 Learn more: https://go.nature.com/49xKvbj
In a recent @cp-cellrepmethods.bsky.social study, scientists generated hPSC-derived T cell progenitors capable of long-term T #lymphopoiesis in vivo without forced expression of defined transcription factors.
💡 https://bit.ly/3LcZnnD
💡 https://bit.ly/3LcZnnD
January 14, 2026 at 5:43 PM
In a recent @cp-cellrepmethods.bsky.social study, scientists generated hPSC-derived T cell progenitors capable of long-term T #lymphopoiesis in vivo without forced expression of defined transcription factors.
💡 https://bit.ly/3LcZnnD
💡 https://bit.ly/3LcZnnD
Dr. Melanie Rutkowski (@rutkowskilab.bsky.social) has been selected as a Victoria’s Secret Rising Innovator, receiving a grant to further her studies of the role of the microbiome in #OvarianCancer and in the disease’s ability to resist immune therapy.
Congratulations! 🤩
🗞️ https://bit.ly/45d2frb
Congratulations! 🤩
🗞️ https://bit.ly/45d2frb
January 13, 2026 at 9:46 PM
Dr. Melanie Rutkowski (@rutkowskilab.bsky.social) has been selected as a Victoria’s Secret Rising Innovator, receiving a grant to further her studies of the role of the microbiome in #OvarianCancer and in the disease’s ability to resist immune therapy.
Congratulations! 🤩
🗞️ https://bit.ly/45d2frb
Congratulations! 🤩
🗞️ https://bit.ly/45d2frb
🚨 This study presents the development and validation of a noninvasive circulating cell-free DNA–based model for early pancreatic cancer detection.
👉 https://bit.ly/457t2Fk
👉 https://bit.ly/457t2Fk
January 13, 2026 at 5:48 PM
🚨 This study presents the development and validation of a noninvasive circulating cell-free DNA–based model for early pancreatic cancer detection.
👉 https://bit.ly/457t2Fk
👉 https://bit.ly/457t2Fk
Piezo1 exacerbates microvascular and skeletal muscle damage in acute limb ischemia–reperfusion injury by facilitating the cPLA2-dependent release of arachidonic acid and promoting ACSL4-driven lipid peroxidation.
👉 https://go.nature.com/3NGmZl6
👉 https://go.nature.com/3NGmZl6
January 13, 2026 at 12:32 AM
Piezo1 exacerbates microvascular and skeletal muscle damage in acute limb ischemia–reperfusion injury by facilitating the cPLA2-dependent release of arachidonic acid and promoting ACSL4-driven lipid peroxidation.
👉 https://go.nature.com/3NGmZl6
👉 https://go.nature.com/3NGmZl6
💪 Investigators at @newcastleuni.bsky.social utilized datasets from single-nuclei RNA sequencing of Duchenne muscular dystrophy muscle samples to examine the dysregulation of molecular pathways in comparison to healthy control muscle.
🔗 https://go.nature.com/4sCKKul
🔗 https://go.nature.com/4sCKKul
January 13, 2026 at 12:28 AM
💪 Investigators at @newcastleuni.bsky.social utilized datasets from single-nuclei RNA sequencing of Duchenne muscular dystrophy muscle samples to examine the dysregulation of molecular pathways in comparison to healthy control muscle.
🔗 https://go.nature.com/4sCKKul
🔗 https://go.nature.com/4sCKKul
In this study with a target trial emulation design, sodium-glucose cotransporter 2 inhibitor use was associated with delayed hormone therapy failure in patients with #ProstateCancer, suggesting a potential oncologic benefit beyond glucose lowering.
🆕 https://bit.ly/4baQ56b
🆕 https://bit.ly/4baQ56b
January 10, 2026 at 12:41 AM
In this study with a target trial emulation design, sodium-glucose cotransporter 2 inhibitor use was associated with delayed hormone therapy failure in patients with #ProstateCancer, suggesting a potential oncologic benefit beyond glucose lowering.
🆕 https://bit.ly/4baQ56b
🆕 https://bit.ly/4baQ56b
A research group from Soochow University found that chromobox 4 upregulation promotes #GastricCancer progression via β-catenin signaling activation.
💡 Learn more: https://bit.ly/4jCFfIi
💡 Learn more: https://bit.ly/4jCFfIi
January 9, 2026 at 9:43 PM
A research group from Soochow University found that chromobox 4 upregulation promotes #GastricCancer progression via β-catenin signaling activation.
💡 Learn more: https://bit.ly/4jCFfIi
💡 Learn more: https://bit.ly/4jCFfIi
Drs. Sarah Herzog, Suzanne Fuqua, and their @bcmhouston.bsky.social colleagues identify replication stress and DNA damage responses as key dysregulated pathways in ESR1 mutant #BreastCancer.
🆕 Check it out: https://bit.ly/49epKTk
🆕 Check it out: https://bit.ly/49epKTk
January 8, 2026 at 11:45 PM
Drs. Sarah Herzog, Suzanne Fuqua, and their @bcmhouston.bsky.social colleagues identify replication stress and DNA damage responses as key dysregulated pathways in ESR1 mutant #BreastCancer.
🆕 Check it out: https://bit.ly/49epKTk
🆕 Check it out: https://bit.ly/49epKTk
🧫 This review comprehensively examines integrative bioengineering strategies for endometrial regeneration, focusing on the synergistic applications of biomaterials, stem cells, #organoids, and organ-on-a-chip technologies.
📖 https://bit.ly/3LlxtWq
📖 https://bit.ly/3LlxtWq
January 8, 2026 at 4:46 PM
🧫 This review comprehensively examines integrative bioengineering strategies for endometrial regeneration, focusing on the synergistic applications of biomaterials, stem cells, #organoids, and organ-on-a-chip technologies.
📖 https://bit.ly/3LlxtWq
📖 https://bit.ly/3LlxtWq
🧠 Scientists find that #glioblastoma stem cells displayed relative resistance to cuproptosis with circadian variation of intracellular copper levels.
👇 Check it out!
@jci.org | https://bit.ly/3YlTzuV
👇 Check it out!
@jci.org | https://bit.ly/3YlTzuV
January 7, 2026 at 4:53 PM
🧠 Scientists find that #glioblastoma stem cells displayed relative resistance to cuproptosis with circadian variation of intracellular copper levels.
👇 Check it out!
@jci.org | https://bit.ly/3YlTzuV
👇 Check it out!
@jci.org | https://bit.ly/3YlTzuV
🔬 Researchers evaluated the immunomodulatory function of PD-L1-(+) MSCs using scRNA-seq and investigated their roles in suppressing inflammation and regulating pathological bone formation in curdlan-induced SKG ankylosing spondylitis mouse models.
🔗 https://bit.ly/4qwlOTE
🔗 https://bit.ly/4qwlOTE
January 6, 2026 at 6:15 PM
🔬 Researchers evaluated the immunomodulatory function of PD-L1-(+) MSCs using scRNA-seq and investigated their roles in suppressing inflammation and regulating pathological bone formation in curdlan-induced SKG ankylosing spondylitis mouse models.
🔗 https://bit.ly/4qwlOTE
🔗 https://bit.ly/4qwlOTE
Scientists including Dr. Shaza Aly assess the #WoundHealing efficacy of fractions derived from Rosmarinus officinalis through phytochemical profiling, antioxidant assays, and in vitro scratch wound models. 🌿
🔎 Take a closer look: https://go.nature.com/495h6X6
🔎 Take a closer look: https://go.nature.com/495h6X6
January 6, 2026 at 1:44 AM
Scientists including Dr. Shaza Aly assess the #WoundHealing efficacy of fractions derived from Rosmarinus officinalis through phytochemical profiling, antioxidant assays, and in vitro scratch wound models. 🌿
🔎 Take a closer look: https://go.nature.com/495h6X6
🔎 Take a closer look: https://go.nature.com/495h6X6
The Dushek lab demonstrated that super selective T cells with reduced cross-reactivity and enhanced ligand discrimination can be generated without impacting on-target potency and importantly, without modifying the TCR.
🔗 https://go.nature.com/4jALBYE
🔗 https://go.nature.com/4jALBYE
January 6, 2026 at 1:27 AM
The Dushek lab demonstrated that super selective T cells with reduced cross-reactivity and enhanced ligand discrimination can be generated without impacting on-target potency and importantly, without modifying the TCR.
🔗 https://go.nature.com/4jALBYE
🔗 https://go.nature.com/4jALBYE
❄️ Happy Holidays!
Our team will be away next week, so there will be a pause in our regular content.
📯 We'll be back the week of January 5th to deliver newsletters and daily posts.
Our team will be away next week, so there will be a pause in our regular content.
📯 We'll be back the week of January 5th to deliver newsletters and daily posts.
December 22, 2025 at 9:13 PM
❄️ Happy Holidays!
Our team will be away next week, so there will be a pause in our regular content.
📯 We'll be back the week of January 5th to deliver newsletters and daily posts.
Our team will be away next week, so there will be a pause in our regular content.
📯 We'll be back the week of January 5th to deliver newsletters and daily posts.
Check out this new study from Dr. Tanya Stoyanova's lab! 🥼
Dr. Alifiani Hartono and team demonstrate that CDC7 is a regulator of tumor progression in #prostate cancer and represents new therapeutic target in advanced prostate cancer. 💊
🔗 https://go.nature.com/3KTvwQQ
Dr. Alifiani Hartono and team demonstrate that CDC7 is a regulator of tumor progression in #prostate cancer and represents new therapeutic target in advanced prostate cancer. 💊
🔗 https://go.nature.com/3KTvwQQ
December 19, 2025 at 4:47 PM
Check out this new study from Dr. Tanya Stoyanova's lab! 🥼
Dr. Alifiani Hartono and team demonstrate that CDC7 is a regulator of tumor progression in #prostate cancer and represents new therapeutic target in advanced prostate cancer. 💊
🔗 https://go.nature.com/3KTvwQQ
Dr. Alifiani Hartono and team demonstrate that CDC7 is a regulator of tumor progression in #prostate cancer and represents new therapeutic target in advanced prostate cancer. 💊
🔗 https://go.nature.com/3KTvwQQ
Dr. Masoud Manjili and collaborators identify Bcl-xL as a central survival factor in chemotherapy-induced dormancy.
They suggest that targeted systemic delivery of A-1331852 may eradicate disseminated dormant cells. #TNBC
🔗 https://go.nature.com/4p5bUau
They suggest that targeted systemic delivery of A-1331852 may eradicate disseminated dormant cells. #TNBC
🔗 https://go.nature.com/4p5bUau
December 19, 2025 at 12:09 AM
Dr. Masoud Manjili and collaborators identify Bcl-xL as a central survival factor in chemotherapy-induced dormancy.
They suggest that targeted systemic delivery of A-1331852 may eradicate disseminated dormant cells. #TNBC
🔗 https://go.nature.com/4p5bUau
They suggest that targeted systemic delivery of A-1331852 may eradicate disseminated dormant cells. #TNBC
🔗 https://go.nature.com/4p5bUau
#Integrin α3 is implicated in #ADHD and other neurodevelopmental disorders.
A study in Molecular Psychiatry identifies hippocampal AMPAR regulation as a key pathway through which ITGA3 influences ADHD-related phenotypes.
https://go.nature.com/4aiBN2P
A study in Molecular Psychiatry identifies hippocampal AMPAR regulation as a key pathway through which ITGA3 influences ADHD-related phenotypes.
https://go.nature.com/4aiBN2P
December 17, 2025 at 11:06 PM
#Integrin α3 is implicated in #ADHD and other neurodevelopmental disorders.
A study in Molecular Psychiatry identifies hippocampal AMPAR regulation as a key pathway through which ITGA3 influences ADHD-related phenotypes.
https://go.nature.com/4aiBN2P
A study in Molecular Psychiatry identifies hippocampal AMPAR regulation as a key pathway through which ITGA3 influences ADHD-related phenotypes.
https://go.nature.com/4aiBN2P
A group of scientists from Sun Yat-sen University show that as #BladderCancer progresses, matrix stiffness and tumor #stemness increase.
High matrix stiffness mediates β-catenin nuclear translocation by increasing the nuclear pore size.
💡 https://go.nature.com/4pEqerl
High matrix stiffness mediates β-catenin nuclear translocation by increasing the nuclear pore size.
💡 https://go.nature.com/4pEqerl
December 17, 2025 at 7:34 PM
A group of scientists from Sun Yat-sen University show that as #BladderCancer progresses, matrix stiffness and tumor #stemness increase.
High matrix stiffness mediates β-catenin nuclear translocation by increasing the nuclear pore size.
💡 https://go.nature.com/4pEqerl
High matrix stiffness mediates β-catenin nuclear translocation by increasing the nuclear pore size.
💡 https://go.nature.com/4pEqerl
Led by Drs. Jocelynn Pearl and Annette Marleau, scientists review clinical advancements in the understanding of the therapeutic properties of MSCs and their subpopulations, assessing the evidence supporting their use in #RegenerativeMedicine.
💡Read it here! bit.ly/48N2kmg
💡Read it here! bit.ly/48N2kmg
December 16, 2025 at 11:59 PM
Led by Drs. Jocelynn Pearl and Annette Marleau, scientists review clinical advancements in the understanding of the therapeutic properties of MSCs and their subpopulations, assessing the evidence supporting their use in #RegenerativeMedicine.
💡Read it here! bit.ly/48N2kmg
💡Read it here! bit.ly/48N2kmg
🧪 Dr. Justus Duyster and team found that the STAT5-activating oncogenes JAK2 p.V617F, FLT3-ITD, and BCR::ABL1 induce oncostatin M, which triggers disease progression and immunosuppression.
@sigtrans-sttt.bsky.social | https://go.nature.com/4q938t4
@sigtrans-sttt.bsky.social | https://go.nature.com/4q938t4
December 16, 2025 at 8:34 PM
🧪 Dr. Justus Duyster and team found that the STAT5-activating oncogenes JAK2 p.V617F, FLT3-ITD, and BCR::ABL1 induce oncostatin M, which triggers disease progression and immunosuppression.
@sigtrans-sttt.bsky.social | https://go.nature.com/4q938t4
@sigtrans-sttt.bsky.social | https://go.nature.com/4q938t4
Hot off the press in @natcomms.nature.com 🔥
Drs. Mads Hald Andersen and Inge Marie Svane report long-term outcomes from the MM1636 trial, which evaluates a peptide vaccine targeting IDO and PD-L1 in combination with nivolumab in patients with melanoma. 💊
https://go.nature.com/48SQ0RE
Drs. Mads Hald Andersen and Inge Marie Svane report long-term outcomes from the MM1636 trial, which evaluates a peptide vaccine targeting IDO and PD-L1 in combination with nivolumab in patients with melanoma. 💊
https://go.nature.com/48SQ0RE
December 16, 2025 at 12:12 AM
Hot off the press in @natcomms.nature.com 🔥
Drs. Mads Hald Andersen and Inge Marie Svane report long-term outcomes from the MM1636 trial, which evaluates a peptide vaccine targeting IDO and PD-L1 in combination with nivolumab in patients with melanoma. 💊
https://go.nature.com/48SQ0RE
Drs. Mads Hald Andersen and Inge Marie Svane report long-term outcomes from the MM1636 trial, which evaluates a peptide vaccine targeting IDO and PD-L1 in combination with nivolumab in patients with melanoma. 💊
https://go.nature.com/48SQ0RE