Stem Cell Reports
@stemcellreports.bsky.social
For scientists. By scientists. The official journal of the @isscr.org | Editor-in-Chief: Janet Rossant, CC, PhD
In this episode of The Stem Cell Report Podcast, guests discuss their investigation on the effect of diverse culture conditions on the cell type composition, gene expression profiles, & maturation status of human PSC-derived intestinal epithelial cells. tinyurl.com/3s4pkj34
November 26, 2025 at 2:54 PM
In this episode of The Stem Cell Report Podcast, guests discuss their investigation on the effect of diverse culture conditions on the cell type composition, gene expression profiles, & maturation status of human PSC-derived intestinal epithelial cells. tinyurl.com/3s4pkj34
New study finds inducible Cars2 mutation in mice causes mitochondrial dysfunction and anemia and Cars2-mutant megakaryocyte-erythroid progenitors (MEPs) generate less erythroblasts, revealing mitochondria as key “navigators” for MEP lineage commitment. https://ow.ly/Xn6U50Xve7I
ISSCR
ISSCR
November 26, 2025 at 1:35 PM
New study finds inducible Cars2 mutation in mice causes mitochondrial dysfunction and anemia and Cars2-mutant megakaryocyte-erythroid progenitors (MEPs) generate less erythroblasts, revealing mitochondria as key “navigators” for MEP lineage commitment. https://ow.ly/Xn6U50Xve7I
ISSCR
ISSCR
New research from NYU Grossman School of Medicine: Stem cell-based approach to identify important regulatory transcription factors in various pathways during mammalian cell differentiation. #development #spinalcord https://ow.ly/i55H50Xve5V
ISSCR | The Gairdner Foundation | SickKids Foundation
ISSCR | The Gairdner Foundation | SickKids Foundation
November 25, 2025 at 3:35 PM
New research from NYU Grossman School of Medicine: Stem cell-based approach to identify important regulatory transcription factors in various pathways during mammalian cell differentiation. #development #spinalcord https://ow.ly/i55H50Xve5V
ISSCR | The Gairdner Foundation | SickKids Foundation
ISSCR | The Gairdner Foundation | SickKids Foundation
New #organoid research models RPGRIP1-inherited retinal disease; connecting cilium, stress response, and #proteostasis abnormalities to inform variant and therapy assessment. #ciliopathies #AAVtherapy #photoreceptors https://ow.ly/xTwl50Xva6s
University of Sydney (USYD) | ISSCR
University of Sydney (USYD) | ISSCR
November 24, 2025 at 4:01 PM
New #organoid research models RPGRIP1-inherited retinal disease; connecting cilium, stress response, and #proteostasis abnormalities to inform variant and therapy assessment. #ciliopathies #AAVtherapy #photoreceptors https://ow.ly/xTwl50Xva6s
University of Sydney (USYD) | ISSCR
University of Sydney (USYD) | ISSCR
Meet Early Career Editor Harsha Devalla at the Assembloids and Complex Cell-Cell Interactions meeting in New York, USA, 8-11 December 2025. Connect with Dr. Devalla to discuss whether your research is a fit for publishing in Stem Cell Reports!
November 24, 2025 at 1:00 PM
Meet Early Career Editor Harsha Devalla at the Assembloids and Complex Cell-Cell Interactions meeting in New York, USA, 8-11 December 2025. Connect with Dr. Devalla to discuss whether your research is a fit for publishing in Stem Cell Reports!
Community and bioethicists’ perspectives on iPSC research with biobanked samples collected using broad consent; support for broad consent, commercial, more benefit sharing, ongoing community engagement, and oversight. https://ow.ly/qApR50Xv90Y
ISSCR | The Gairdner Foundation | SickKids Foundation
ISSCR | The Gairdner Foundation | SickKids Foundation
November 21, 2025 at 7:05 PM
Community and bioethicists’ perspectives on iPSC research with biobanked samples collected using broad consent; support for broad consent, commercial, more benefit sharing, ongoing community engagement, and oversight. https://ow.ly/qApR50Xv90Y
ISSCR | The Gairdner Foundation | SickKids Foundation
ISSCR | The Gairdner Foundation | SickKids Foundation
Meet Early Career Editor Bruno Di Stefano (Bruno Di Stefano) at #ASH2025 in Orlando, USA 6-9 December 2025. Connect with Dr. Di Stefano to discuss whether your research is a fit for publishing in Stem Cell Reports!
November 21, 2025 at 3:00 PM
Meet Early Career Editor Bruno Di Stefano (Bruno Di Stefano) at #ASH2025 in Orlando, USA 6-9 December 2025. Connect with Dr. Di Stefano to discuss whether your research is a fit for publishing in Stem Cell Reports!
New article explores 4,481 YouTube videos about stem cells to map how medical knowledge is shared online, revealing a complex discourse dominated by celebrity influencers in the promotion and discussion of putative stem cell treatments. https://ow.ly/iNUG50Xv8Ay
November 20, 2025 at 10:04 PM
New article explores 4,481 YouTube videos about stem cells to map how medical knowledge is shared online, revealing a complex discourse dominated by celebrity influencers in the promotion and discussion of putative stem cell treatments. https://ow.ly/iNUG50Xv8Ay
New paper from Center for iPS Cell Research and Application (CiRA)! Aging reduces KAT7/HBO1 activity, impairing immortalized megakaryocyte progenitor cell line (imMKCL)-based platelet production by promoting immune-like properties via the cGAS-STING pathway. #cellcycle https://ow.ly/J80850XrNh1
November 20, 2025 at 8:00 PM
New paper from Center for iPS Cell Research and Application (CiRA)! Aging reduces KAT7/HBO1 activity, impairing immortalized megakaryocyte progenitor cell line (imMKCL)-based platelet production by promoting immune-like properties via the cGAS-STING pathway. #cellcycle https://ow.ly/J80850XrNh1
Online now! #Autophagy is dispensable in germline stem cells but is required in the cap cells for maintaining the #Drosophila ovarian niche. Atg5-mediated autophagy preserves cap cell viability and BMP signaling during #aging. https://ow.ly/Zhum50XrN46
ISSCR
ISSCR
November 19, 2025 at 3:01 PM
Online now! #Autophagy is dispensable in germline stem cells but is required in the cap cells for maintaining the #Drosophila ovarian niche. Atg5-mediated autophagy preserves cap cell viability and BMP signaling during #aging. https://ow.ly/Zhum50XrN46
ISSCR
ISSCR
New research from UT Southwestern Medical Center: Analysis of 1,996,260 sequenced cells across benchmarking datasets reveals shared regulatory networks linking disease-associated enhancers and genes with downstream targets during cardiomyocyte differentiation. https://ow.ly/czPo50XrMAL
ISSCR
ISSCR
November 18, 2025 at 8:05 PM
New research from UT Southwestern Medical Center: Analysis of 1,996,260 sequenced cells across benchmarking datasets reveals shared regulatory networks linking disease-associated enhancers and genes with downstream targets during cardiomyocyte differentiation. https://ow.ly/czPo50XrMAL
ISSCR
ISSCR
Online now! First derivation of nuclear transfer embryonic stem cells (ntESCs) from cloned blastocysts generated by somatic cell nuclear transfer in the #marmoset; ntESCs show normal karyotypes & #pluripotency. https://ow.ly/Xkus50XrM7Z
ISSCR | The Gairdner Foundation | SickKids Foundation
ISSCR | The Gairdner Foundation | SickKids Foundation
November 17, 2025 at 4:05 PM
Online now! First derivation of nuclear transfer embryonic stem cells (ntESCs) from cloned blastocysts generated by somatic cell nuclear transfer in the #marmoset; ntESCs show normal karyotypes & #pluripotency. https://ow.ly/Xkus50XrM7Z
ISSCR | The Gairdner Foundation | SickKids Foundation
ISSCR | The Gairdner Foundation | SickKids Foundation
New organ-on-chip research! Gene expression profiling reveals enhanced nutrient and drug metabolism and maturation of hiPSC-derived intestine-on-chip relative to organoids and Transwells. #iPSC #organonchip #organoid https://ow.ly/hBIX50XrKs2
ISSCR | The Gairdner Foundation | SickKids Foundation
ISSCR | The Gairdner Foundation | SickKids Foundation
November 14, 2025 at 3:07 PM
New organ-on-chip research! Gene expression profiling reveals enhanced nutrient and drug metabolism and maturation of hiPSC-derived intestine-on-chip relative to organoids and Transwells. #iPSC #organonchip #organoid https://ow.ly/hBIX50XrKs2
ISSCR | The Gairdner Foundation | SickKids Foundation
ISSCR | The Gairdner Foundation | SickKids Foundation
Exploring advances & challenges in modeling Charcot-Marie-Tooth type 2A (#CMT2A) using iPSC-based models, focusing on pathogenetic insights, elucidating disease mechanisms, & developing innovative testing platforms & therapeutic strategies. https://ow.ly/B1pf50XrgNF
ISSCR
ISSCR
November 13, 2025 at 6:12 PM
Exploring advances & challenges in modeling Charcot-Marie-Tooth type 2A (#CMT2A) using iPSC-based models, focusing on pathogenetic insights, elucidating disease mechanisms, & developing innovative testing platforms & therapeutic strategies. https://ow.ly/B1pf50XrgNF
ISSCR
ISSCR
A novel paradigm for single-cell annotation in stem cell research. Explores different approaches, implementation challenge in stem cell-derived models, and offers recommendations and a vision for the future. #hPSC #singlecell #cellulargenomics #AI #cellannotation https://ow.ly/jwl050Xo5Fq
ISSCR
ISSCR
November 12, 2025 at 9:45 PM
A novel paradigm for single-cell annotation in stem cell research. Explores different approaches, implementation challenge in stem cell-derived models, and offers recommendations and a vision for the future. #hPSC #singlecell #cellulargenomics #AI #cellannotation https://ow.ly/jwl050Xo5Fq
ISSCR
ISSCR
Loss-of-function analysis of the #Oct4 distal (DE) and proximal enhancers (PE) shows that Oct4 PE and DE are required for primed and naive pluripotency, respectively. Powerful genetic tools to dissect Oct4’s role in #pluripotency & early development. https://ow.ly/JShz50Xo5nz
ISSCR
ISSCR
November 11, 2025 at 5:35 PM
Loss-of-function analysis of the #Oct4 distal (DE) and proximal enhancers (PE) shows that Oct4 PE and DE are required for primed and naive pluripotency, respectively. Powerful genetic tools to dissect Oct4’s role in #pluripotency & early development. https://ow.ly/JShz50Xo5nz
ISSCR
ISSCR
New #organoid research shows transplanted human stomach organoids can induce gastric insulin-secreting cells in vivo. Potential for future therapeutic development using this technology for insulin-dependent #diabetes. https://ow.ly/88W850Xo2nR
ISSCR | The Gairdner Foundation | SickKids Foundation
ISSCR | The Gairdner Foundation | SickKids Foundation
November 10, 2025 at 9:10 PM
New #organoid research shows transplanted human stomach organoids can induce gastric insulin-secreting cells in vivo. Potential for future therapeutic development using this technology for insulin-dependent #diabetes. https://ow.ly/88W850Xo2nR
ISSCR | The Gairdner Foundation | SickKids Foundation
ISSCR | The Gairdner Foundation | SickKids Foundation
Meet our Early Career Editor at #ASSCR2025! Pengyi Yang is attending the Australasian Society for Stem Cell Research (ASSCR) Conference in Gold Coast, Australia, 10-12 November 2025. Connect with Dr. Yang to discuss whether your research is a fit for publishing in Stem Cell Reports!
November 10, 2025 at 7:00 PM
Meet our Early Career Editor at #ASSCR2025! Pengyi Yang is attending the Australasian Society for Stem Cell Research (ASSCR) Conference in Gold Coast, Australia, 10-12 November 2025. Connect with Dr. Yang to discuss whether your research is a fit for publishing in Stem Cell Reports!
Online now! ModulatingJAK2-STAT3 pathway promotes expansion & maturation of human iPSC-derived myogenic progenitor cells; advancing in vitro generation of skeletal muscle progenitor cells for potential cell therapy applications. https://ow.ly/6qAz50XkBvY
Sanford Burnham Prebys | ISSCR
Sanford Burnham Prebys | ISSCR
November 7, 2025 at 4:55 PM
Online now! ModulatingJAK2-STAT3 pathway promotes expansion & maturation of human iPSC-derived myogenic progenitor cells; advancing in vitro generation of skeletal muscle progenitor cells for potential cell therapy applications. https://ow.ly/6qAz50XkBvY
Sanford Burnham Prebys | ISSCR
Sanford Burnham Prebys | ISSCR
Online now! An evolutionary conserved role for EZH2-polycomb repressive complex 2 (PRC2) in safeguarding #pluripotency from primitive #endoderm cell fate. #hypoblast #transdifferentiation https://ow.ly/Q2eZ50XkBks
ISSCR | Cell Press | SickKids Foundation | The Gairdner Foundation
ISSCR | Cell Press | SickKids Foundation | The Gairdner Foundation
November 6, 2025 at 8:00 PM
Online now! An evolutionary conserved role for EZH2-polycomb repressive complex 2 (PRC2) in safeguarding #pluripotency from primitive #endoderm cell fate. #hypoblast #transdifferentiation https://ow.ly/Q2eZ50XkBks
ISSCR | Cell Press | SickKids Foundation | The Gairdner Foundation
ISSCR | Cell Press | SickKids Foundation | The Gairdner Foundation
New in Stem Cell Reports: Activation of canonical #Wnt signaling increases efficiency for direct reprogramming efficiency into human hepatic progenitor cells https://ow.ly/kcFf50XkB3k
ISSCR | Cell Press | The Gairdner Foundation | SickKids Foundation
ISSCR | Cell Press | The Gairdner Foundation | SickKids Foundation
November 5, 2025 at 5:10 PM
New in Stem Cell Reports: Activation of canonical #Wnt signaling increases efficiency for direct reprogramming efficiency into human hepatic progenitor cells https://ow.ly/kcFf50XkB3k
ISSCR | Cell Press | The Gairdner Foundation | SickKids Foundation
ISSCR | Cell Press | The Gairdner Foundation | SickKids Foundation
Early Career Editor Amy Wong (Amy Wong 🇨🇦) is attending the CANCOR 2025: Canadian Conference for Organoid Research today in Ontario, Canada. Connect with her to discuss whether your research is a fit for publishing in Stem Cell Reports!
November 5, 2025 at 1:00 PM
Early Career Editor Amy Wong (Amy Wong 🇨🇦) is attending the CANCOR 2025: Canadian Conference for Organoid Research today in Ontario, Canada. Connect with her to discuss whether your research is a fit for publishing in Stem Cell Reports!
Meet our Early Career Editor at #CANCOR2025! Amy Wong is attending the Canadian Conference for Organoid Research in Ontario, Canada, 5-6 November 2025. Connect with Dr. Wong to discuss whether your research is a fit for publishing in Stem Cell Reports!
November 4, 2025 at 8:30 PM
Meet our Early Career Editor at #CANCOR2025! Amy Wong is attending the Canadian Conference for Organoid Research in Ontario, Canada, 5-6 November 2025. Connect with Dr. Wong to discuss whether your research is a fit for publishing in Stem Cell Reports!
New from Mayo Clinic: Differentiation of stem cell-derived pancreatic β-cells induces #circadian clock genes, and transplanted SCβ-cells exhibit circadian rhythms in #insulin secretion & optimize insulin secretion to host’s circadian phase https://ow.ly/XMmg50XkARN
ISSCR
ISSCR
November 4, 2025 at 5:30 PM
New from Mayo Clinic: Differentiation of stem cell-derived pancreatic β-cells induces #circadian clock genes, and transplanted SCβ-cells exhibit circadian rhythms in #insulin secretion & optimize insulin secretion to host’s circadian phase https://ow.ly/XMmg50XkARN
ISSCR
ISSCR
#Hypoxia dynamically alters oligodendrocyte precursor cell (OPC)phenotypes post-stroke; “oxygen tone” as a key regulator of OPC dynamic adaptation after stroke, offering a promising strategy for stroke #celltherapy. https://ow.ly/6k0m50XkAyR
ISSCR | SickKids Foundation | The Gairdner Foundation
ISSCR | SickKids Foundation | The Gairdner Foundation
November 3, 2025 at 9:40 PM
#Hypoxia dynamically alters oligodendrocyte precursor cell (OPC)phenotypes post-stroke; “oxygen tone” as a key regulator of OPC dynamic adaptation after stroke, offering a promising strategy for stroke #celltherapy. https://ow.ly/6k0m50XkAyR
ISSCR | SickKids Foundation | The Gairdner Foundation
ISSCR | SickKids Foundation | The Gairdner Foundation