Stefan Rothenburg
@stefanrothenburg.bsky.social
Virology, Host-Virus Interactions and Evolution, Poxviruses, Arboviruses, PKR, RNase L, Translational Regulation
University of California, Davis
https://health.ucdavis.edu/medmicro/faculty/rothenburg/
University of California, Davis
https://health.ucdavis.edu/medmicro/faculty/rothenburg/
1/4 A previously identified mutation in VACV K3L that allowed better replication in sheep cells, better inhibited sheep PKR, but not human PKR, and led to decreased inhibition of mouse PKR, showing that a single mutation in a viral protein can result in distinct species-dependent inhibition changes
December 2, 2025 at 9:07 PM
1/4 A previously identified mutation in VACV K3L that allowed better replication in sheep cells, better inhibited sheep PKR, but not human PKR, and led to decreased inhibition of mouse PKR, showing that a single mutation in a viral protein can result in distinct species-dependent inhibition changes
1/3 Site-directed mutagenesis and domain swap experiment with cow and sheep PKR showed that the sensitivity to K3L and 011 was partially determined by different residues and regions in PKR.
December 2, 2025 at 9:06 PM
1/3 Site-directed mutagenesis and domain swap experiment with cow and sheep PKR showed that the sensitivity to K3L and 011 was partially determined by different residues and regions in PKR.
1/2 We first compared the sensitivity of PKR from 20 mammals to K3L inhibition. Some PKRs were inhibited by only one K3 ortholog, whereas other PKRs were either resistant or sensitive to both inhibitors.
December 2, 2025 at 9:06 PM
1/2 We first compared the sensitivity of PKR from 20 mammals to K3L inhibition. Some PKRs were inhibited by only one K3 ortholog, whereas other PKRs were either resistant or sensitive to both inhibitors.
