Srishti Patil
@srishtipatil.bsky.social
(she/her) PhD student working on colorectal cancer evolution in the theoretical systems biology division @DKFZ, Heidelberg
Reposted by Srishti Patil
In the latest from the lab (www.biorxiv.org/content/10.1...), PhD student Amjad Dabi used simulation to investigate the emergence of resistance to therapy in cancer under an evolutionary rescue model. Why does treatment for some cancers fail after a period of initial effectiveness? (1/n)
Evolutionary rescue model informs strategies for driving cancer cell populations to extinction
Cancers exhibit a remarkable ability to develop resistance to a range of treatments, often resulting in relapse following first-line therapies and significantly worse outcomes for subsequent treatment...
www.biorxiv.org
January 17, 2025 at 7:17 PM
In the latest from the lab (www.biorxiv.org/content/10.1...), PhD student Amjad Dabi used simulation to investigate the emergence of resistance to therapy in cancer under an evolutionary rescue model. Why does treatment for some cancers fail after a period of initial effectiveness? (1/n)
Reposted by Srishti Patil
New preprint! When I started in #mathonco and cancer #evobio, I had to teach myself computational modelling from paper methods sections. Many things I learned only by years of trial and error. To make it easier for others, we present a non-technical step by step guide. arxiv.org/abs/2311.03569. 1/2
A seven-step guide to spatial, agent-based modelling of tumour evolution
Spatial agent-based models are increasingly used to investigate the evolution
of solid tumours subject to localised cell-cell interactions and
microenvironmental heterogeneity. Here we present a...
arxiv.org
November 8, 2023 at 9:35 AM
New preprint! When I started in #mathonco and cancer #evobio, I had to teach myself computational modelling from paper methods sections. Many things I learned only by years of trial and error. To make it easier for others, we present a non-technical step by step guide. arxiv.org/abs/2311.03569. 1/2