Dr Soraya M
@sorayam.bsky.social
Post doc at UKDRI/UniOfEdinburgh. Dementia researcher. Electrophysiology. She/Her. Field hockey enthusiast. @drsorayam on the bad place
A stimulating two days at the @alzheimersresearchuk.org Scotland Network meeting. Of course a trip to Dundee cannot be done without a visit to F&D (if you know you know).
August 22, 2025 at 2:26 PM
A stimulating two days at the @alzheimersresearchuk.org Scotland Network meeting. Of course a trip to Dundee cannot be done without a visit to F&D (if you know you know).
It’s been one of those mornings 😪
July 3, 2025 at 11:39 AM
It’s been one of those mornings 😪
Fabulous talk by the lovely @emmayhnell.bsky.social hwre at @edinunineuro.bsky.social talking about teaching and engaging students with lots of fun tidbits and ideas to consider. Think about your strengths, different modes or medias and maybe make it personal!
June 4, 2025 at 4:53 PM
Fabulous talk by the lovely @emmayhnell.bsky.social hwre at @edinunineuro.bsky.social talking about teaching and engaging students with lots of fun tidbits and ideas to consider. Think about your strengths, different modes or medias and maybe make it personal!
Really privileged to be spending the week at the University of Eastern Finland, giving a talk as part of their course on electrophysiological techniques for human neuron function and also enjoying the wonderful location and weather.
May 12, 2025 at 3:12 PM
Really privileged to be spending the week at the University of Eastern Finland, giving a talk as part of their course on electrophysiological techniques for human neuron function and also enjoying the wonderful location and weather.
Finally we also saw amyloid-B and tau pathology in ~ 1/4 of our samples and we further explore how this relates to protein secretion. This is exciting as it gives us a system to study human pathology in living human brain in real time!
April 30, 2025 at 3:22 PM
Finally we also saw amyloid-B and tau pathology in ~ 1/4 of our samples and we further explore how this relates to protein secretion. This is exciting as it gives us a system to study human pathology in living human brain in real time!
Conversely, treatment with Alzheimer’s disease derived brain extract containing amyloid-B (vs that which had been immunodepleted for amyloid-B) led to loss of synapses with no compensation by mRNA.
April 30, 2025 at 3:22 PM
Conversely, treatment with Alzheimer’s disease derived brain extract containing amyloid-B (vs that which had been immunodepleted for amyloid-B) led to loss of synapses with no compensation by mRNA.
Happy with our cultures, we wanted to see the response to physiological vs pathological amyloid-B manipulations. We increased and decreased physiological amyloid-B production using drugs. Interestingly alteration of amyloid-B showed a loss of synapses with a compensatory response in synaptic mRNA.
April 30, 2025 at 3:22 PM
Happy with our cultures, we wanted to see the response to physiological vs pathological amyloid-B manipulations. We increased and decreased physiological amyloid-B production using drugs. Interestingly alteration of amyloid-B showed a loss of synapses with a compensatory response in synaptic mRNA.
Next we wanted to understand how “patient features” e.g. age, sex, apoE genotype, brain region the tissue came from relates to medium secretion of known dementia-associated markers. One cool finding was that brain region altered 4/8 markers, and tau was higher in temporal vs frontal cortex samples.
April 30, 2025 at 3:22 PM
Next we wanted to understand how “patient features” e.g. age, sex, apoE genotype, brain region the tissue came from relates to medium secretion of known dementia-associated markers. One cool finding was that brain region altered 4/8 markers, and tau was higher in temporal vs frontal cortex samples.
One key aim of this work was to help develop and validate more translatable models for dementia research. Therefore, we sought to characterise and define living human brain slice cultures to model dementia in our hands. We show we have examples of tissue preservation after 7 days in culture.
April 30, 2025 at 3:22 PM
One key aim of this work was to help develop and validate more translatable models for dementia research. Therefore, we sought to characterise and define living human brain slice cultures to model dementia in our hands. We show we have examples of tissue preservation after 7 days in culture.
Lovely weather to kick off #BNA2025 Excited for a few days of incredible neuroscience. Join me in the Desert Island Papers session Mon 9:30-11:15 talking to Prof Tole or at my poster Tues 1:50-3:20 discussing how we use human brain slice cultures to model dementia (our paper is out on weds!)
April 27, 2025 at 2:17 PM
Lovely weather to kick off #BNA2025 Excited for a few days of incredible neuroscience. Join me in the Desert Island Papers session Mon 9:30-11:15 talking to Prof Tole or at my poster Tues 1:50-3:20 discussing how we use human brain slice cultures to model dementia (our paper is out on weds!)
My enormous what? 🤭😂
April 24, 2025 at 1:36 PM
My enormous what? 🤭😂
This means very little to most but a good week on #fpl finally! I’m still off my target but likely achievable. 😅 it’s been a long season.
April 24, 2025 at 5:59 AM
This means very little to most but a good week on #fpl finally! I’m still off my target but likely achievable. 😅 it’s been a long season.
The pastries in question 👀
April 23, 2025 at 10:31 AM
The pastries in question 👀
A great flavour of the breadth of neuroscience at Edinburgh this morning from informatics to behaviour to a bonus guest speaker! #NeuroDay2025 #EdNeuroDay @edinunineuro.bsky.social
April 23, 2025 at 9:41 AM
A great flavour of the breadth of neuroscience at Edinburgh this morning from informatics to behaviour to a bonus guest speaker! #NeuroDay2025 #EdNeuroDay @edinunineuro.bsky.social
Looking forward to seeing all the exciting research at Edinburgh Neuroscience Day! #EdNeuroDay @edinunineuro.bsky.social
Also looking forward to eating my body weight in pastries. 🥐
Also looking forward to eating my body weight in pastries. 🥐
April 23, 2025 at 8:22 AM
Looking forward to seeing all the exciting research at Edinburgh Neuroscience Day! #EdNeuroDay @edinunineuro.bsky.social
Also looking forward to eating my body weight in pastries. 🥐
Also looking forward to eating my body weight in pastries. 🥐
I always feel like this is what you imagine “coding” to look like. And it looks pretty cool to be fair! 😂 This is part of the process of identifying putative single neurons in electrode array datasets.
April 10, 2025 at 7:45 AM
I always feel like this is what you imagine “coding” to look like. And it looks pretty cool to be fair! 😂 This is part of the process of identifying putative single neurons in electrode array datasets.
Animals. But I’ve also entered 😂🙏🏽
April 4, 2025 at 1:14 PM
Animals. But I’ve also entered 😂🙏🏽
I’ve had crazy electrical noise plaguing our multi electrode array recordings for weeks. It’s always a flipping salt bridge! However, I got to make my first bubble trap and now everything looks ok.
⚡️🧠 🧪
⚡️🧠 🧪
March 4, 2025 at 3:19 PM
I’ve had crazy electrical noise plaguing our multi electrode array recordings for weeks. It’s always a flipping salt bridge! However, I got to make my first bubble trap and now everything looks ok.
⚡️🧠 🧪
⚡️🧠 🧪
Another amazing #ARUKConf25 as per usual! Catching up with friends, seeing and chatting about amazing science is always a boost. Also lovely to see such a nice tribute to Mike O’Neill, former boss of mine and killer researcher in dementia drug discovery. Can’t wait to get home to bed now 😴
February 26, 2025 at 10:08 PM
Another amazing #ARUKConf25 as per usual! Catching up with friends, seeing and chatting about amazing science is always a boost. Also lovely to see such a nice tribute to Mike O’Neill, former boss of mine and killer researcher in dementia drug discovery. Can’t wait to get home to bed now 😴
For the main conference, the wonderful and inspiring Jordan Adams, reminding us why our research is so important.
#ARUK25 #ARUKConf25 @alzheimersresearchuk.org
#ARUK25 #ARUKConf25 @alzheimersresearchuk.org
February 25, 2025 at 10:00 AM
For the main conference, the wonderful and inspiring Jordan Adams, reminding us why our research is so important.
#ARUK25 #ARUKConf25 @alzheimersresearchuk.org
#ARUK25 #ARUKConf25 @alzheimersresearchuk.org
What a great start to the ECR day #ARUKConf25 #ARUK25 My favourite bit of the conference is always talks from supporters and Zac did not disappoint, talking about his dad Imran Sherwani, world renowned hockey player who has been diagnosed with early onset dementia. @alzheimersresearchuk.org
February 24, 2025 at 12:08 PM
What a great start to the ECR day #ARUKConf25 #ARUK25 My favourite bit of the conference is always talks from supporters and Zac did not disappoint, talking about his dad Imran Sherwani, world renowned hockey player who has been diagnosed with early onset dementia. @alzheimersresearchuk.org
World and/or America on fire but at least our MEA can still record some spikes 🤩 great distraction by our MSc student from fellowship writing this afternoon.
(Organotypic cerebellar slice cultures in high KCl aCSF, the red arrows show detected spike activity).
🧠🥼🧪
(Organotypic cerebellar slice cultures in high KCl aCSF, the red arrows show detected spike activity).
🧠🥼🧪
February 11, 2025 at 8:29 PM
World and/or America on fire but at least our MEA can still record some spikes 🤩 great distraction by our MSc student from fellowship writing this afternoon.
(Organotypic cerebellar slice cultures in high KCl aCSF, the red arrows show detected spike activity).
🧠🥼🧪
(Organotypic cerebellar slice cultures in high KCl aCSF, the red arrows show detected spike activity).
🧠🥼🧪