Sonja Blasche
@sonjablasche.bsky.social
Senior Research Associate at MRC Toxicology, University of Cambridge
My research interests focus on interspecies-interactions in gut and food microbial communities, their effects and benefits, as well as bacterial responses to drugs and food compounds.
My research interests focus on interspecies-interactions in gut and food microbial communities, their effects and benefits, as well as bacterial responses to drugs and food compounds.
Our findings highlight widespread combination effects between commonly co-consumed chemicals in gut bacteria. A collaborative effort with Vinita, @noniberistain.bsky.social @indraroux.bsky.social @skamrad.bsky.social @rbradley.bsky.social @guan06rui.bsky.social @itsbinir.bsky.social and more!(5/5)
April 4, 2025 at 12:17 PM
Our findings highlight widespread combination effects between commonly co-consumed chemicals in gut bacteria. A collaborative effort with Vinita, @noniberistain.bsky.social @indraroux.bsky.social @skamrad.bsky.social @rbradley.bsky.social @guan06rui.bsky.social @itsbinir.bsky.social and more!(5/5)
Proteomic, metabolomic, and genetic analyses revealed altered small molecule transport underlying this sweetener-drug synergy. This combination also modulated metabolism in a synthetic gut bacterial community, increasing toxicity and altering the secretion of cytokines in human cells. (4/5)
April 4, 2025 at 12:17 PM
Proteomic, metabolomic, and genetic analyses revealed altered small molecule transport underlying this sweetener-drug synergy. This combination also modulated metabolism in a synthetic gut bacterial community, increasing toxicity and altering the secretion of cytokines in human cells. (4/5)
We identified over 100 synergistic and antagonistic growth effects upon co-exposure. For example, isosteviol + duloxetine synergistically inhibited Roseburia intestinalis, a bacterium associated with glucose homeostasis, and Parabacteroides merdae, a prevalent commensal. (3/5)
April 4, 2025 at 12:17 PM
We identified over 100 synergistic and antagonistic growth effects upon co-exposure. For example, isosteviol + duloxetine synergistically inhibited Roseburia intestinalis, a bacterium associated with glucose homeostasis, and Parabacteroides merdae, a prevalent commensal. (3/5)
We tested 39 commercially used sweeteners for their effects on 25 gut-associated bacterial strains. To uncover combinatorial effects, we combined them with four commonly consumed compounds: the sweetener advantame, caffeine, vanillin, and the antidepressant duloxetine. (2/5)
April 4, 2025 at 12:17 PM
We tested 39 commercially used sweeteners for their effects on 25 gut-associated bacterial strains. To uncover combinatorial effects, we combined them with four commonly consumed compounds: the sweetener advantame, caffeine, vanillin, and the antidepressant duloxetine. (2/5)