Scott Soleimanpour
@soleimanpourlab.bsky.social
Physician-scientist w/ type 1 diabetes | Director, Michigan Diabetes Research Center | ❤️s - family, coffee, mitochondria, disordered proteins. Opinions mine.
http://michmed.org/soleimanpour-lab
http://michmed.org/soleimanpour-lab
Thank you!!! And congrats again!
November 15, 2025 at 2:57 PM
Thank you!!! And congrats again!
Congrats Peter and team!!! Excited to check it out! Would you mind reposting the link? For some reason, it doesn’t work. Thanks!
November 14, 2025 at 9:09 AM
Congrats Peter and team!!! Excited to check it out! Would you mind reposting the link? For some reason, it doesn’t work. Thanks!
Mitophagy defects also negatively alter the ER redox environment. Not the most profound statement, but ER-mito crosstalk/cascades are likely a very important contributor to diabetes!
October 24, 2025 at 12:27 PM
Mitophagy defects also negatively alter the ER redox environment. Not the most profound statement, but ER-mito crosstalk/cascades are likely a very important contributor to diabetes!
Thank you and excellent question! Misfolded proinsulin and ER stress definitely will elicit mito changes. Akita mice also have mito structural defects. In other cell types, ER stress causes mito fusion (maybe to compensate)? We have not examined mitophagy in these models ourselves though.
October 24, 2025 at 12:27 PM
Thank you and excellent question! Misfolded proinsulin and ER stress definitely will elicit mito changes. Akita mice also have mito structural defects. In other cell types, ER stress causes mito fusion (maybe to compensate)? We have not examined mitophagy in these models ourselves though.