Benefits of using 211At include:
· Does not require molecular targeted drugs
· Reduces treatment burden
· Limits adverse effects associated with systemic therapies

Read the full article here: t.co/cIW2dYKfBb

Alpha-emitters were effective and well-tolerated to treat refractory patients with DTC -- with either 2.5 or 3.5 MBq/kg, though a dose-limiting toxicity existed at 3.5 MBq/kg. Thyroglobulin was reduced 50% and uptake in radioactive iodine-avid lesions on 131I SPECT decreased.

Patients with DTC who were refractory to radioactive iodine were given a single intravenous dose of 211At-NaAt.

The study used thyroglobulin measurement, CT imaging, and 131I SPECT to evaluate patient responses.

Podcast: PET-Guided Radiotherapy: Reflections?

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FEATURED: First-in-Human Study of [211At]NaAt as Targeted α-Therapy in Patients with Radioiodine-Refractory Thyroid Cancer (Alpha-T1 Trial)

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FEATURED: PET Imaging of System A Amino Acid Transport Detects Early Response to Immune Checkpoint Inhibitor Therapy in a Syngeneic Mouse Model

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Is It Really Happening? α-Therapy and Combination Strategies to Overcome Resistance and Enhance Clinical Outcomes in Prostate Cancer

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The State of the Art: Current Developments in Combining External-Beam Radiotherapy and 177Lu-Labeled PSMA Ligands for Prostate Cancer Treatment

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Discussions with Leaders: Translating Discovery into Impact with Caius Radu

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A 100% Complete Response Rate Shows Promise--85% of mice also achieved histologic cure. 1 and 2-cycle treatments were equally effective and well-tolerated. In the patient xenograft, a single 225Ac treatment achieved a 60% response and prolonged survival compared to no treatment.

Though previous studies have shown that HER2-targeted radiotherapies with the alpha-particle-emitting radionuclide 225Ac were effective, they were not safe for patients, as 225Ac was retained in the body, causing high toxicity.

FEATURED: CXCR4 PET/CT Predicts Left Ventricular Recovery 8 Months After Acute Myocardial Infarction: jnm.snmjournals.org/content/66/1...

FEATURED: 225Ac α-Pretargeted Radioimmunotherapy of Human Epidermal Growth Factor Receptor 2–Expressing Breast Cancer: jnm.snmjournals.org/content/66/1...

The State of the Art: Comparison, Agreement, and Significance Cutoffs of 18F-Flurpiridaz PET Myocardial Blood Flow Quantitation Methods and Software Packages: jnm.snmjournals.org/content/66/1...

Discussions with Leaders: Translating Research Amidst Transnational Quarrels: jnm.snmjournals.org/content/66/1...