Marie Sadler
@smarie-smarie.bsky.social
Statistical geneticist, PhD | Basel, Switzerland ⛰️🇨🇭 | genetics 🧬 | omics 🟠🔺🟩 | drug targets 🎯| pharmacogenetics 💊
We study the genetics of drug efficacy using longitudinal biomarker and medication prescription data from #EHRs. 🧬💊
Have a look at the 🧵 on i) modelling drug response and biomarker progression, ii) using #PRS to predict efficacy and iii) the challenges with #EHRs.
www.nature.com/articles/s41...
Have a look at the 🧵 on i) modelling drug response and biomarker progression, ii) using #PRS to predict efficacy and iii) the challenges with #EHRs.
www.nature.com/articles/s41...
April 1, 2025 at 8:12 PM
We study the genetics of drug efficacy using longitudinal biomarker and medication prescription data from #EHRs. 🧬💊
Have a look at the 🧵 on i) modelling drug response and biomarker progression, ii) using #PRS to predict efficacy and iii) the challenges with #EHRs.
www.nature.com/articles/s41...
Have a look at the 🧵 on i) modelling drug response and biomarker progression, ii) using #PRS to predict efficacy and iii) the challenges with #EHRs.
www.nature.com/articles/s41...
Tissue-specific co-expression networks to identify key genes 🧬 Have a look at Patrick's thread that explains how Downstreamer can link common genetic variation to rare diseases. Thank you for including Zoltán and me on this project!
Downstreamer is now available: www.nature.com/articles/s41... We used 57 tissue specific gene expression networks to identify key genes of common diseases. 78% of these key genes are located outside of GWAS loci. 1/4
December 6, 2024 at 1:25 PM
Tissue-specific co-expression networks to identify key genes 🧬 Have a look at Patrick's thread that explains how Downstreamer can link common genetic variation to rare diseases. Thank you for including Zoltán and me on this project!