Slavov Laboratory
@slavovlab.bsky.social
We seek principles in the coordination among protein synthesis, metabolism, cell growth and differentiation. PI: @slavov-n.bsky.social
Web: https://slavovlab.net
Videos: http://youtube.slavovlab.net
Web: https://slavovlab.net
Videos: http://youtube.slavovlab.net
he multiplexing capabilities introduced by Parallel Squared Technology Institute (@parallelsq.bsky.social) can substantially increase the scalability of these methods.
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www.parallelsq.org/publications
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www.parallelsq.org/publications
Publications - PTI - Parallel Squared Technology Institute
Parallel Squared Technology Institute is a non-profit research institute that’s scaling up proteomics to illuminate the link between protein patterns, functional interactions, and disease.
www.parallelsq.org
November 20, 2025 at 2:59 PM
he multiplexing capabilities introduced by Parallel Squared Technology Institute (@parallelsq.bsky.social) can substantially increase the scalability of these methods.
3/3
www.parallelsq.org/publications
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www.parallelsq.org/publications
We are exited about the experimental opportunities enabled by these approaches and the potential to increasingly bring dynamics to omics scale analyses of tissues at single-cell resolution.
November 20, 2025 at 2:59 PM
We are exited about the experimental opportunities enabled by these approaches and the potential to increasingly bring dynamics to omics scale analyses of tissues at single-cell resolution.
Preprint:
Principles of protein abundance regulation across single cells in a mammalian tissue
www.biorxiv.org/content/10.1...
Principles of protein abundance regulation across single cells in a mammalian tissue
www.biorxiv.org/content/10.1...
Principles of protein abundance regulation across single cells in a mammalian tissue
Protein synthesis and clearance are major regulatory steps of gene expression, but their in vivo regulatory roles across the cells comprising complex tissues remains unexplored. Here, we systematicall...
www.biorxiv.org
October 25, 2025 at 12:40 PM
Preprint:
Principles of protein abundance regulation across single cells in a mammalian tissue
www.biorxiv.org/content/10.1...
Principles of protein abundance regulation across single cells in a mammalian tissue
www.biorxiv.org/content/10.1...
Preprint:
Alternate RNA decoding results in stable and abundant proteins in mammals
www.biorxiv.org/content/10.1...
Alternate RNA decoding results in stable and abundant proteins in mammals
www.biorxiv.org/content/10.1...
Alternate RNA decoding results in stable and abundant proteins in mammals
Amino acid substitutions may substantially alter protein stability and function, but the contribution of substitutions arising from alternate translation (deviations from the genetic code) is unknown....
www.biorxiv.org
October 25, 2025 at 12:31 PM
Preprint:
Alternate RNA decoding results in stable and abundant proteins in mammals
www.biorxiv.org/content/10.1...
Alternate RNA decoding results in stable and abundant proteins in mammals
www.biorxiv.org/content/10.1...
Yeast metabolic and signaling genes are required for heat-shock survival and have little overlap with the heat-induced genes
www.pnas.org/doi/abs/10.1...
www.pnas.org/doi/abs/10.1...
Yeast metabolic and signaling genes are required for heat-shock survival and have little overlap with the heat-induced genes | PNAS
Genome-wide gene-expression studies have shown that hundreds of yeast genes are induced
or repressed transiently by changes in temperature; many ar...
www.pnas.org
October 13, 2025 at 1:31 PM
Yeast metabolic and signaling genes are required for heat-shock survival and have little overlap with the heat-induced genes
www.pnas.org/doi/abs/10.1...
www.pnas.org/doi/abs/10.1...
Protein clearance rates vary across proteins in inverse proportion to the average cell-type doubling rate.
This explains the degree to which protein clearance (degradation) sets protein abundance.
biorxiv.org/content/10.1...
This explains the degree to which protein clearance (degradation) sets protein abundance.
biorxiv.org/content/10.1...
September 21, 2025 at 11:55 AM
Protein clearance rates vary across proteins in inverse proportion to the average cell-type doubling rate.
This explains the degree to which protein clearance (degradation) sets protein abundance.
biorxiv.org/content/10.1...
This explains the degree to which protein clearance (degradation) sets protein abundance.
biorxiv.org/content/10.1...
Some proteins are primarily regulated by one mechanism: RNA abundance, translation, or clearance.
The regulation of most proteins is dominated by different regulatory mechanisms across cell types.
Gratifyingly, this complex regulation defines simple rules
The regulation of most proteins is dominated by different regulatory mechanisms across cell types.
Gratifyingly, this complex regulation defines simple rules
September 21, 2025 at 11:54 AM
Some proteins are primarily regulated by one mechanism: RNA abundance, translation, or clearance.
The regulation of most proteins is dominated by different regulatory mechanisms across cell types.
Gratifyingly, this complex regulation defines simple rules
The regulation of most proteins is dominated by different regulatory mechanisms across cell types.
Gratifyingly, this complex regulation defines simple rules
Our experimental design aimed for:
- Direct measurements
- Quantitative accuracy supporting confident modeling
- Scalable multiplexing & generalizable approach approach
- Direct measurements
- Quantitative accuracy supporting confident modeling
- Scalable multiplexing & generalizable approach approach
September 21, 2025 at 11:11 AM
Our experimental design aimed for:
- Direct measurements
- Quantitative accuracy supporting confident modeling
- Scalable multiplexing & generalizable approach approach
- Direct measurements
- Quantitative accuracy supporting confident modeling
- Scalable multiplexing & generalizable approach approach