AbstractRepetitive TMS (rTMS) is a powerful neuroscientific tool with the potential to noninvasively identify brain–behavior relationships in humans. Early work suggested that certain rTMS protocols (e.g., continuous theta-burst stimulation, intermittent theta-burst stimulation, high-frequency rTMS, low-frequency rTMS) predictably alter the probability that cortical neurons will fire action potentials (i.e., change cortical excitability). However, despite significant methodological, conceptual, and technical advances in rTMS research over the past few decades, overgeneralization of early rTMS findings has led to a stubbornly persistent assumption that rTMS protocols by their nature induce behavioral and/or physiological inhibition or facilitation, even when they are applied to nonmotor cortical sites or under untested circumstances. In this Perspectives article, we offer a “public service announcement” that summarizes the origins of this problematic assumption, highlighting limitations of seminal studies that inspired them and results of contemporary studies that violate them. Next, we discuss problems associated with holding this assumption, including making brain–behavior inferences without confirming the locality and directionality of neurophysiological changes. Finally, we provide recommendations for researchers to eliminate this misguided assumption when designing and interpreting their own work, emphasizing results of recent studies showing that the effects of rTMS on neurophysiological metrics and their associated behaviors can be caused by mechanisms other than binary changes in excitability of the stimulated brain region or network. Collectively, we contend that no rTMS protocol is by its nature either excitatory or inhibitory, and that researchers must use caution with these terms when forming experimental hypotheses and testing brain–behavior relationships.

Seeber et al. studied brain recordings from implanted electrodes in freely moving humans. Neural dynamics encoded actual and imagined routes similarly, demonstrating parallels between navigational, im...

Job Details: Our mission is to identify the brain circuits responsible for symptoms common in autism and other neurodevelop

The Dawson Professorship of Young People's Mental Health in the Department of Psychology at the University of Cambridge.