Simona Cristea
simocristea.bsky.social
Simona Cristea
@simocristea.bsky.social
Genomics, LLMs, spatial cancer evo | Group leader @DanaFarber @Harvard | Head of Data Science at Hale Center for Pancreatic Cancer | PhD @eth
If you’re having a bad science day, remember that Victor Ambros was denied tenure at Harvard only one year after discovering microRNAs - for which he was ultimately awarded the Nobel Prize.
January 5, 2025 at 12:04 AM
100 🦋 followes 🎊🙏🙏
December 7, 2024 at 4:26 AM
This paper looks at single cell DNA seq data from normal & cancer tissues and computes how evolution is changing within each tissue.

In most cancers and half of normal tissues, the paper rejects a constant evolutionary rate - potentially explainable by mutations in driver genes.

t.co/P3LgFWbHMG
December 5, 2024 at 2:08 AM
Contrary to what was thought - that immune cells cannot infiltrate the brain - anticancer active T cells do exist in the brain, specifically inside the bone marrow in the skull.

These exact cells might be the future of immune therapies against brain cancers.

www.nature.com/articles/d41...
December 3, 2024 at 12:22 AM
Investing in sequencing tumors from multiple parts of the world is not wasting money. In fact, it benefits everybody

Here’s why: in practice, we have no idea why/when cells in our body mutate, either healthy aging or malignant shifts

How much does the environment contribute?
December 1, 2024 at 9:51 PM
Hi Blusesky people, any advice how to quickly change my feed to less nature/animal photos and more science content? Like how can nudge this algo so it learns what to show?
November 26, 2024 at 4:05 AM