Sean Rudd
@seanrudd.bsky.social
Group leader @ Karolinska Institutet & SciLifeLab in Stockholm, Sweden. Interested in understanding how cancer drugs work.
Lab site - https://www.seanruddlab.com/
Genome stability | dNTP metabolism | Cancer therapy
Lab site - https://www.seanruddlab.com/
Genome stability | dNTP metabolism | Cancer therapy
Reposted by Sean Rudd
Our data complements recent works from the Yang, Kubicek/Huber, DeBerardinis, and Jourdain labs to position NUDT5 as a core regulator of nucleotide metabolism and rheostat of NA drug efficacy.
A huge thanks to the Altun lab, SciLifeLab DDDP, @seanrudd.bsky.social, and others.
3/n
A huge thanks to the Altun lab, SciLifeLab DDDP, @seanrudd.bsky.social, and others.
3/n
November 21, 2025 at 3:43 PM
Our data complements recent works from the Yang, Kubicek/Huber, DeBerardinis, and Jourdain labs to position NUDT5 as a core regulator of nucleotide metabolism and rheostat of NA drug efficacy.
A huge thanks to the Altun lab, SciLifeLab DDDP, @seanrudd.bsky.social, and others.
3/n
A huge thanks to the Altun lab, SciLifeLab DDDP, @seanrudd.bsky.social, and others.
3/n
Reposted by Sean Rudd
We find that NUDT5-depleted cells are stuck in de novo purine biosynthesis (DNPB) with impaired nucleotide salvage. NUDT5 binds PPAT, the rate-limiting enzyme of DNPB, and appears to regulate its activity and PRPP availability to impair salvage-mediated NA drug activation.
2/n
2/n
November 21, 2025 at 3:43 PM
We find that NUDT5-depleted cells are stuck in de novo purine biosynthesis (DNPB) with impaired nucleotide salvage. NUDT5 binds PPAT, the rate-limiting enzyme of DNPB, and appears to regulate its activity and PRPP availability to impair salvage-mediated NA drug activation.
2/n
2/n
Reposted by Sean Rudd
Check our new website – night-science.org – and consider also helping us to launch the Night Science Institute!
July 29, 2025 at 2:59 PM
Check our new website – night-science.org – and consider also helping us to launch the Night Science Institute!