Shih-Chieh Lin
@sclin-lab.bsky.social
Neuroscience Professor @ National Yang Ming Chiao Tung University, Taiwan | NIH alum | neurophysiology | decision making | attention | reward | #BasalForebrain
Reposted by Shih-Chieh Lin
🚨Our preprint is online!🚨
www.biorxiv.org/content/10.1...
How do #dopamine neurons perform the key calculations in reinforcement #learning?
Read on to find out more! 🧵
www.biorxiv.org/content/10.1...
How do #dopamine neurons perform the key calculations in reinforcement #learning?
Read on to find out more! 🧵
September 19, 2025 at 1:05 PM
🚨Our preprint is online!🚨
www.biorxiv.org/content/10.1...
How do #dopamine neurons perform the key calculations in reinforcement #learning?
Read on to find out more! 🧵
www.biorxiv.org/content/10.1...
How do #dopamine neurons perform the key calculations in reinforcement #learning?
Read on to find out more! 🧵
Reposted by Shih-Chieh Lin
Now out in @natcomms.nature.com: Mice and monkeys spontaneously shift through comparable cognitive states - and it's written all over their faces! (1/7)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Inferring internal states across mice and monkeys using facial features - Nature Communications
Here, the authors created a virtual reality task for monkeys and mice to explore if internal states like attention are similar across species. Their facial expressions during the task were similar, su...
www.nature.com
June 10, 2025 at 11:21 AM
Now out in @natcomms.nature.com: Mice and monkeys spontaneously shift through comparable cognitive states - and it's written all over their faces! (1/7)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Shih-Chieh Lin
Together with this paper by the group of Joe Paton www.nature.com/articles/s41... our results across the two papers complement each other providing strong evidence that distinct dopamine neurons discount future rewards at different rates providing a substrate for multi-timescale RL in the brain
A multidimensional distributional map of future reward in dopamine neurons - Nature
An algorithm called time–magnitude reinforcement learning (TMRL) extends distributional reinforcement learning to take account of reward time and magnitude, and behavioural and neurophysiological...
www.nature.com
June 4, 2025 at 6:11 PM
Together with this paper by the group of Joe Paton www.nature.com/articles/s41... our results across the two papers complement each other providing strong evidence that distinct dopamine neurons discount future rewards at different rates providing a substrate for multi-timescale RL in the brain
Reposted by Shih-Chieh Lin
Our work with Pablo Tano, @hyunggoo-kim.bsky.social Athar Malik, Alexandre Pouget and @naoshigeuchida.bsky.social exploring how dopamine neurons could enable multi-timescale reinforcement learning in the brain is out in @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Multi-timescale reinforcement learning in the brain - Nature
Individual dopaminergic neurons encode future rewards over distinct temporal horizons.
www.nature.com
June 4, 2025 at 6:11 PM
Our work with Pablo Tano, @hyunggoo-kim.bsky.social Athar Malik, Alexandre Pouget and @naoshigeuchida.bsky.social exploring how dopamine neurons could enable multi-timescale reinforcement learning in the brain is out in @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Great work from my next door neighbor!
My debut on BlueSky! Here’s how we harvest the firing of neurons to see them better in the living brain! 👇
www.nature.com/articles/s41...
Grateful for the amazing dyes from @rhodamine110.bsky.social and insightful suggestions from @adamezracohen.bsky.social !
www.nature.com/articles/s41...
Grateful for the amazing dyes from @rhodamine110.bsky.social and insightful suggestions from @adamezracohen.bsky.social !
May 23, 2025 at 1:36 PM
Great work from my next door neighbor!
Reposted by Shih-Chieh Lin
Big Congratulations Tsai-Wen!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Imaging neuronal voltage beyond the scattering limit - Nature Methods
ALI is an approach for analyzing voltage imaging data that is inspired by algorithms used in super-resolution microscopy. It allows resolving the activity of single neurons in densely labeled populati...
www.nature.com
May 22, 2025 at 1:43 PM
Big Congratulations Tsai-Wen!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Shih-Chieh Lin
Impressive study in @nature from my colleague Marcus Stephenson-Jones at UCL in the @sainsburywellcome.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Dopaminergic action prediction errors serve as a value-free teaching signal - Nature
Dopaminergic action prediction error signals are used by mice as a value-free teaching signal to reinforce stable sound–action associations in the tail of the striatum.
www.nature.com
May 15, 2025 at 9:47 AM
Impressive study in @nature from my colleague Marcus Stephenson-Jones at UCL in the @sainsburywellcome.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Shih-Chieh Lin
1/7 Our paper on individual variability in decision-making is finally out in @nature.com! Inspired by the classic work by Mante and Sussillo, we trained many rats to solve context-dependent decision-making, and we found that different brains use different neural mechanisms to solve the same task!
Individual variability of neural computations underlying flexible decisions - Nature
Behavioural experiments to study decision-making in response to context-dependent accumulation of evidence provide testable models that are consistent with the heterogeneity in neural signatures among...
www.nature.com
March 21, 2025 at 1:29 PM
1/7 Our paper on individual variability in decision-making is finally out in @nature.com! Inspired by the classic work by Mante and Sussillo, we trained many rats to solve context-dependent decision-making, and we found that different brains use different neural mechanisms to solve the same task!
Congrats to @kepecslab.bsky.social !
1/ Why do patients with late-stage cancer lose motivation & sink into apathy?
🔥 Our new Science paper shows chronic inflammation activates a cytokine-sensing brain circuit that lowers motivation. Huge team effort: Aelita Zhu, Sarah Starosta, Pignatelli & Janowitz labs! 🧵
🔗 doi.org/10.1126/scie...
🔥 Our new Science paper shows chronic inflammation activates a cytokine-sensing brain circuit that lowers motivation. Huge team effort: Aelita Zhu, Sarah Starosta, Pignatelli & Janowitz labs! 🧵
🔗 doi.org/10.1126/scie...
A neuroimmune circuit mediates cancer cachexia-associated apathy
Cachexia, a severe wasting syndrome associated with inflammatory conditions, often leads to multiorgan failure and death. Patients with cachexia experience extreme fatigue, apathy, and clinical depres...
doi.org
April 11, 2025 at 2:28 PM
Congrats to @kepecslab.bsky.social !
Reposted by Shih-Chieh Lin
Some glimmers of hope (but mostly confusion) this morning.
I have heard that no intramural tenure track investigators were supposed to be on the termination list although some folks clearly got termination notices.
I am actively checking into this every way I can.
1/2
I have heard that no intramural tenure track investigators were supposed to be on the termination list although some folks clearly got termination notices.
I am actively checking into this every way I can.
1/2
a picture of a pikachu with the words " i still have hope " written below it
ALT: a picture of a pikachu with the words " i still have hope " written below it
media.tenor.com
February 16, 2025 at 12:44 PM
Some glimmers of hope (but mostly confusion) this morning.
I have heard that no intramural tenure track investigators were supposed to be on the termination list although some folks clearly got termination notices.
I am actively checking into this every way I can.
1/2
I have heard that no intramural tenure track investigators were supposed to be on the termination list although some folks clearly got termination notices.
I am actively checking into this every way I can.
1/2
This is atrocious!
The damage today (actually yesterday) to the intramural program appears to especially bad.
It also appears (although I need more confirmation) that most or all of the tenure track investigators in their first 2 years in several, and perhaps all, institutes were terminated.
7/n
It also appears (although I need more confirmation) that most or all of the tenure track investigators in their first 2 years in several, and perhaps all, institutes were terminated.
7/n
February 16, 2025 at 7:31 AM
This is atrocious!
Reposted by Shih-Chieh Lin
Very interesting paper on a potential role for proprioceptors in sensing muscle acidosis and driving the perception of soreness.
"Sng" is a Taiwanese word for both sour taste and muscle soreness. It also imitates the natural vocalization of humans feeling sore.
www.science.org/doi/10.1126/...
"Sng" is a Taiwanese word for both sour taste and muscle soreness. It also imitates the natural vocalization of humans feeling sore.
www.science.org/doi/10.1126/...
A role for proprioceptors in sngception
Proprioceptors mediate acidosis sensation that contributes to acid-induced pain chronicity.
www.science.org
January 31, 2025 at 11:40 PM
Very interesting paper on a potential role for proprioceptors in sensing muscle acidosis and driving the perception of soreness.
"Sng" is a Taiwanese word for both sour taste and muscle soreness. It also imitates the natural vocalization of humans feeling sore.
www.science.org/doi/10.1126/...
"Sng" is a Taiwanese word for both sour taste and muscle soreness. It also imitates the natural vocalization of humans feeling sore.
www.science.org/doi/10.1126/...
Reposted by Shih-Chieh Lin
(1/30) New preprint! "Symmetries and continuous attractors in disordered neural circuits" with Larry Abbott and Haim Sompolinsky
bioRxiv: www.biorxiv.org/content/10.1...
bioRxiv: www.biorxiv.org/content/10.1...
Symmetries and Continuous Attractors in Disordered Neural Circuits
A major challenge in neuroscience is reconciling idealized theoretical models with complex, heterogeneous experimental data. We address this challenge through the lens of continuous-attractor networks...
www.biorxiv.org
January 29, 2025 at 6:26 PM
(1/30) New preprint! "Symmetries and continuous attractors in disordered neural circuits" with Larry Abbott and Haim Sompolinsky
bioRxiv: www.biorxiv.org/content/10.1...
bioRxiv: www.biorxiv.org/content/10.1...
Reposted by Shih-Chieh Lin
Two papers out showing that thalamic inputs determine how cortex responds to a hierarchical task with rule switching:
www.nature.com/articles/s41...
journals.plos.org/plosbiology/...
🧠📈 🧪
www.nature.com/articles/s41...
journals.plos.org/plosbiology/...
🧠📈 🧪
Prefrontal transthalamic uncertainty processing drives flexible switching - Nature
By examining neural responses from tree shrews performing hierarchical decision tasks with rule reversals, the authors identify a thalamocortical mechanism for regulating cognitive flexibility.
www.nature.com
January 3, 2025 at 7:43 PM
Two papers out showing that thalamic inputs determine how cortex responds to a hierarchical task with rule switching:
www.nature.com/articles/s41...
journals.plos.org/plosbiology/...
🧠📈 🧪
www.nature.com/articles/s41...
journals.plos.org/plosbiology/...
🧠📈 🧪
Reposted by Shih-Chieh Lin
These essays offer the neuroscience community a place to explore the culture and practice of the field; to debate major questions; to examine the craft of neuroscience; and to trace its evolution over time. Download the book now: www.thetransmitter.org/transmitter-...
The Transmitter books
The Transmitter’s first book, “Thinking about neuroscience: Essays from the field,” features a rich collection of writing from researchers Nicole Rust, Anthony Zador and many more.
www.thetransmitter.org
December 18, 2024 at 5:30 PM
These essays offer the neuroscience community a place to explore the culture and practice of the field; to debate major questions; to examine the craft of neuroscience; and to trace its evolution over time. Download the book now: www.thetransmitter.org/transmitter-...
Reposted by Shih-Chieh Lin
Our preprint of my PhD’s work in @gisellavetere.bsky.social lab is finally out on BiorXiv: doi.org/10.1101/2024..., and I’m so excited to share it! If you’ve ever wondered about reconciling engram manipulation experiments and neuronal activity during encoding, you’re on the right thread! 1/14
Deconstruction of a memory engram reveals distinct ensembles recruited at learning
How are associative memories formed? Which cells represent a memory, and when are they engaged? By visualizing and tagging cells based on their calcium influx with unparalleled temporal precision, we ...
doi.org
December 13, 2024 at 12:50 PM
Our preprint of my PhD’s work in @gisellavetere.bsky.social lab is finally out on BiorXiv: doi.org/10.1101/2024..., and I’m so excited to share it! If you’ve ever wondered about reconciling engram manipulation experiments and neuronal activity during encoding, you’re on the right thread! 1/14
Reposted by Shih-Chieh Lin
Neuroscience students asked us to teach a PRACTICAL course on experimental methods, and it is now on YouTube!
Please like and repost to help us get the word out!
www.youtube.com/playlist?lis...
Lecture 1: Signals and data acquisition
Focusing on hardware, digital/analog I/O, synchronization
🧵
Please like and repost to help us get the word out!
www.youtube.com/playlist?lis...
Lecture 1: Signals and data acquisition
Focusing on hardware, digital/analog I/O, synchronization
🧵
Neuroscience methods - YouTube
Nanocourse: Approaches to Study Neural Circuits This course was taught by Anita Autry, Tiago Gonçalves, and Luke Sjulson at Albert Einstein College of Medici...
www.youtube.com
December 13, 2024 at 11:33 AM
Neuroscience students asked us to teach a PRACTICAL course on experimental methods, and it is now on YouTube!
Please like and repost to help us get the word out!
www.youtube.com/playlist?lis...
Lecture 1: Signals and data acquisition
Focusing on hardware, digital/analog I/O, synchronization
🧵
Please like and repost to help us get the word out!
www.youtube.com/playlist?lis...
Lecture 1: Signals and data acquisition
Focusing on hardware, digital/analog I/O, synchronization
🧵
Really elegant work by @behrenstimb.bsky.social group. The idea of structured memory buffers provides a nice framework to understand 'goal-progress cells’ activity in the mPFC while mice learn a common task structure across many tasks. Not the easiest paper to read but really worthwhile!
December 11, 2024 at 1:03 AM
Really elegant work by @behrenstimb.bsky.social group. The idea of structured memory buffers provides a nice framework to understand 'goal-progress cells’ activity in the mPFC while mice learn a common task structure across many tasks. Not the easiest paper to read but really worthwhile!
Reposted by Shih-Chieh Lin
Thrilled to present our latest BioRXiv on brain/body interactions during defensive freezing behaviour! (www.biorxiv.org/content/10.1...). You might think that a frozen animal has, well, frozen muscle activity, right? Wrong! Underneath the still surface of a fly, something in the legs is beating… 🧵
December 2, 2024 at 9:57 AM
Thrilled to present our latest BioRXiv on brain/body interactions during defensive freezing behaviour! (www.biorxiv.org/content/10.1...). You might think that a frozen animal has, well, frozen muscle activity, right? Wrong! Underneath the still surface of a fly, something in the legs is beating… 🧵
Reposted by Shih-Chieh Lin
Thanks Kevin!
And thanks to my collaborators @alexkoulakov.bsky.social
Sergey Shuvaev and Divyansha Lachi !
(S & D -- have you joined the party here yet?)
And thanks to my collaborators @alexkoulakov.bsky.social
Sergey Shuvaev and Divyansha Lachi !
(S & D -- have you joined the party here yet?)
A wonderful paper from @tonyzador.bsky.social and colleagues: Encoding innate ability through a genomic bottleneck www.pnas.org/doi/10.1073/...
Encoding innate ability through a genomic bottleneck | PNAS
Animals are born with extensive innate behavioral capabilities, which arise from neural
circuits encoded in the genome. However, the information ca...
www.pnas.org
November 28, 2024 at 2:25 PM
Thanks Kevin!
And thanks to my collaborators @alexkoulakov.bsky.social
Sergey Shuvaev and Divyansha Lachi !
(S & D -- have you joined the party here yet?)
And thanks to my collaborators @alexkoulakov.bsky.social
Sergey Shuvaev and Divyansha Lachi !
(S & D -- have you joined the party here yet?)
Reposted by Shih-Chieh Lin
Another huge influx of colleagues to BlueSky this week, so let me attach the fully updated Neurophysiology starter pack for anyone interested.
go.bsky.app/9FY1ReG
go.bsky.app/9FY1ReG
November 30, 2024 at 1:15 AM
Another huge influx of colleagues to BlueSky this week, so let me attach the fully updated Neurophysiology starter pack for anyone interested.
go.bsky.app/9FY1ReG
go.bsky.app/9FY1ReG
Reposted by Shih-Chieh Lin
OpenScholar: AI for scientific paper research
- Finds papers & summarizes content for user queries
- Trained on 45M+ Semantic Scholar papers
- 8B parameters
GitHub: github.com/AkariAsai/Op...
- Finds papers & summarizes content for user queries
- Trained on 45M+ Semantic Scholar papers
- 8B parameters
GitHub: github.com/AkariAsai/Op...
GitHub - AkariAsai/OpenScholar: This repository includes the official implementation of OpenScholar: Synthesizing Scientific Literature with Retrieval-augmented LMs.
This repository includes the official implementation of OpenScholar: Synthesizing Scientific Literature with Retrieval-augmented LMs. - GitHub - AkariAsai/OpenScholar: This repository includes the...
github.com
November 24, 2024 at 5:17 AM
OpenScholar: AI for scientific paper research
- Finds papers & summarizes content for user queries
- Trained on 45M+ Semantic Scholar papers
- 8B parameters
GitHub: github.com/AkariAsai/Op...
- Finds papers & summarizes content for user queries
- Trained on 45M+ Semantic Scholar papers
- 8B parameters
GitHub: github.com/AkariAsai/Op...
Just immigrated to Bsky. Really like the atmosphere and discussions here and reminded me of why I loved science twitter. Starter packs are very helpful and there are tools to convert starter packs into lists like this one:
nws-bot.us/bskyStarterP...
nws-bot.us/bskyStarterP...
Convert BSky Starter Pack to List
nws-bot.us
November 24, 2024 at 12:43 AM
Just immigrated to Bsky. Really like the atmosphere and discussions here and reminded me of why I loved science twitter. Starter packs are very helpful and there are tools to convert starter packs into lists like this one:
nws-bot.us/bskyStarterP...
nws-bot.us/bskyStarterP...
Reposted by Shih-Chieh Lin
Huge influx of neuroscientists migrates to Bluesky
www.thetransmitter.org/community/hu...
#Neuroscience
www.thetransmitter.org/community/hu...
#Neuroscience
‘Huge influx’ of neuroscientists migrates to Bluesky
Daily neuroscience-related posts on the social-media platform this week have increased more than 400 percent, on average, compared with October.
www.thetransmitter.org
November 23, 2024 at 8:09 PM
Huge influx of neuroscientists migrates to Bluesky
www.thetransmitter.org/community/hu...
#Neuroscience
www.thetransmitter.org/community/hu...
#Neuroscience
Reposted by Shih-Chieh Lin
Just put together the beginnings of a systems & behavior neuro starter pack (focus on rodent work) - obviously a lot of people missing, and most included are in my own little bubble, so if you want to be added do reply here! go.bsky.app/Hxpe53o
November 10, 2024 at 11:58 PM
Just put together the beginnings of a systems & behavior neuro starter pack (focus on rodent work) - obviously a lot of people missing, and most included are in my own little bubble, so if you want to be added do reply here! go.bsky.app/Hxpe53o