The Science of Parkinson's
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scienceofpd.bsky.social
The Science of Parkinson's
@scienceofpd.bsky.social
Personal account of the Director of Research at Cure Parkinson's - All views my own - Kiwi - Kia kaha - 侘寂 - https://scienceofparkinsons.com/
Could be interesting to replicate this study in the double variant carriers (LRRK2+GBA). Am thinking of Ortega et al 2021 - have always wondered why the combo carriers have slower progression
pubmed.ncbi.nlm.nih.gov/33881531/
Association of Dual LRRK2 G2019S and GBA Variations With Parkinson Disease Progression - PubMed
These findings suggest that longitudinal cognitive decline in patients with GBA PD was more severe than in those with LRRK2/GBA PD, which more closely resembled LRRK2 PD. This further supports the notion of a dominant association of LRRK2 on GBA in individuals who carry both and raises the possibili …
pubmed.ncbi.nlm.nih.gov
November 21, 2025 at 9:48 AM