Schmitt Lab @ UCLA
@schmittlab-ucla.bsky.social
We develop tools for imaging cellular spatiotemporal regulation of metabolism in the Department of Chem & Biochem @ UCLA
🔬New Preprint Alert 🔬 How is AMPK regulated by oxidative stress? We use functional imaging to uncover spatial regulation of AMPK activity during oxidative stress by LKB1 & CaMKK2. Combining imaging with proteomics & metabolomics, we find AMPK works to promote the cellular redox response.
Spatial regulation of AMPK activity under oxidative stress requires LKB1 https://www.biorxiv.org/content/10.1101/2025.11.17.688926v1
November 18, 2025 at 3:56 AM
🔬New Preprint Alert 🔬 How is AMPK regulated by oxidative stress? We use functional imaging to uncover spatial regulation of AMPK activity during oxidative stress by LKB1 & CaMKK2. Combining imaging with proteomics & metabolomics, we find AMPK works to promote the cellular redox response.
Schmitt Lab Photo Day!
October 20, 2025 at 11:46 PM
Schmitt Lab Photo Day!
🎀 New from the lab 🎀 We used the SPARK design for kinase biosensors to develop a PINK1 biosensor, PINK1-SPARK. We used PINK1-SPARK to measure PINK1 activity in multiple cell types & when using HaloTag, for multiplexing! Plasmids coming soon, check out the preprint: www.biorxiv.org/content/10.1...
Visualizing PINK1 Activity Dynamics in Single Cells with a Phase Separation-Based Kinase Activity Reporter
Phosphatase and tensin homologue-induced kinase 1 (PINK1) is a serine/threonine kinase that plays roles in mitophagy, cell death, and regulation of cellular bioenergetics. Current approaches for study...
www.biorxiv.org
October 16, 2025 at 11:38 PM
🎀 New from the lab 🎀 We used the SPARK design for kinase biosensors to develop a PINK1 biosensor, PINK1-SPARK. We used PINK1-SPARK to measure PINK1 activity in multiple cell types & when using HaloTag, for multiplexing! Plasmids coming soon, check out the preprint: www.biorxiv.org/content/10.1...
Reposted by Schmitt Lab @ UCLA
“It backfired,” said one senior administrator at UCLA, reflecting the sense of whiplash felt among many who were interviewed. “Within hours of announcing our settlement, the DOJ was on our back.”
www.latimes.com/california/s...
www.latimes.com/california/s...
Ivy League universities paid hundreds of millions to settle with Trump. Is UCLA next?
President Trump's higher education battle comes to the University of California. After the Department of Justice found that UCLA had violated Jewish students' civil rights, the administration froze hu...
www.latimes.com
August 4, 2025 at 11:36 PM
“It backfired,” said one senior administrator at UCLA, reflecting the sense of whiplash felt among many who were interviewed. “Within hours of announcing our settlement, the DOJ was on our back.”
www.latimes.com/california/s...
www.latimes.com/california/s...
Reposted by Schmitt Lab @ UCLA
Science is foundational to the San Diego region. Cuts in federal funding will harm STEM training and education and threaten this foundation. Call your congress people and demand NO CUTS to science funding!
Opinion: Cuts in federal funding hammer STEM students and San Diego region
This year’s federal funding cuts are severely impacting STEM research and education, threatening the future of innovation and our nation’s health and technological advancement. These cuts hav…
www.sandiegouniontribune.com
August 4, 2025 at 7:28 PM
Science is foundational to the San Diego region. Cuts in federal funding will harm STEM training and education and threaten this foundation. Call your congress people and demand NO CUTS to science funding!
Reposted by Schmitt Lab @ UCLA
A story from LAist (local LA public radio) about the freezing of funds. I have had my grant frozen, so has nearly everyone else i know. laist.com/news/climate...
UCLA tells researchers to 'immediately stop spending' after Trump administration freezes grant funds
The Trump administration cited alleged antisemitism at UCLA as a reason for suspending the funding. Years worth of research could be lost, one UCLA researcher said.
laist.com
August 2, 2025 at 9:58 PM
A story from LAist (local LA public radio) about the freezing of funds. I have had my grant frozen, so has nearly everyone else i know. laist.com/news/climate...
Today the Schmitt Lab had our 2nd Annual Professional Development Day! To start the day, we reviewed the State of the Lab, and discussed plans for current and future funding and publications. Next, we reviewed statistics and what the null hypothesis is.
July 23, 2025 at 11:28 PM
Today the Schmitt Lab had our 2nd Annual Professional Development Day! To start the day, we reviewed the State of the Lab, and discussed plans for current and future funding and publications. Next, we reviewed statistics and what the null hypothesis is.
🎉Congrats Katarina, who passed her advancement to candidacy today! 🥳
June 16, 2025 at 7:20 PM
🎉Congrats Katarina, who passed her advancement to candidacy today! 🥳
🥳 Congrats Alexia, who has advanced to candidacy! Alexia did a wonderful job! 🍾
June 11, 2025 at 9:51 PM
🥳 Congrats Alexia, who has advanced to candidacy! Alexia did a wonderful job! 🍾
Today at the @uclacb.bsky.social several members of the Schmitt Lab received awards for excellence in research and teaching. 🎉 Congrats, everyone! 🥳
June 10, 2025 at 12:16 AM
Today at the @uclacb.bsky.social several members of the Schmitt Lab received awards for excellence in research and teaching. 🎉 Congrats, everyone! 🥳
🎉 Congrats Teagan, who advanced to candidacy today! Teagan is co-mentored by Danielle & @tarateslaa.bsky.social. Teagan did a great job! 🥳
June 4, 2025 at 10:52 PM
🎉 Congrats Teagan, who advanced to candidacy today! Teagan is co-mentored by Danielle & @tarateslaa.bsky.social. Teagan did a great job! 🥳
🎉Congrats to Tiffany, who advanced to candidacy today! She did a great job! 🥳
June 3, 2025 at 8:47 PM
🎉Congrats to Tiffany, who advanced to candidacy today! She did a great job! 🥳
🎉 congrats Katie, who advanced to candidacy today!! 🍾
June 2, 2025 at 11:18 PM
🎉 congrats Katie, who advanced to candidacy today!! 🍾
Reposted by Schmitt Lab @ UCLA
I am so honored to be nominated & receive a UCLA Undergraduate Research Week Mentor Award! It means so much to me to be acknowledged for my efforts in mentoring my undergrad students & helping them be successful in the lab & beyond. Thank you to my students for all their hard work & the nomination!
May 23, 2025 at 9:45 PM
I am so honored to be nominated & receive a UCLA Undergraduate Research Week Mentor Award! It means so much to me to be acknowledged for my efforts in mentoring my undergrad students & helping them be successful in the lab & beyond. Thank you to my students for all their hard work & the nomination!
Congrats Marvin, on becoming a PhD Candidate! 🥳 Marvin is co-mentored by Danielle and Pavak Shah. Marvin did great! 🍾
May 22, 2025 at 7:53 PM
Congrats Marvin, on becoming a PhD Candidate! 🥳 Marvin is co-mentored by Danielle and Pavak Shah. Marvin did great! 🍾
Reposted by Schmitt Lab @ UCLA
Katie & I are having a great time at SoCal SysBio, despite melting during the outdoor poster session (it’s 104F at UC Riverside) 🫠
May 10, 2025 at 9:23 PM
Katie & I are having a great time at SoCal SysBio, despite melting during the outdoor poster session (it’s 104F at UC Riverside) 🫠
🥳 Congrats to Kasey and Sid on their research award and SURF award, respectively. We are so proud of them and excited for what they'll do in the lab!
May 1, 2025 at 5:33 PM
🥳 Congrats to Kasey and Sid on their research award and SURF award, respectively. We are so proud of them and excited for what they'll do in the lab!
🥳 Congrats to Kasey, a 3rd year undergraduate in the lab, who won her category at the ASBMB Undergraduate Poster Competition! We are so proud of Kasey and her co-authors for all their hard work!
April 13, 2025 at 8:17 PM
🥳 Congrats to Kasey, a 3rd year undergraduate in the lab, who won her category at the ASBMB Undergraduate Poster Competition! We are so proud of Kasey and her co-authors for all their hard work!
Congrats to Tiffany, a chem bio grad student in the lab, who received an NSF Honorable Mention!
April 8, 2025 at 7:59 PM
Congrats to Tiffany, a chem bio grad student in the lab, who received an NSF Honorable Mention!
The Schmitt Lab will be at Discover BMB in Chicago! Check out our three posters and one short talk. This is sure to be a fantastic meeting.
April 8, 2025 at 5:57 AM
The Schmitt Lab will be at Discover BMB in Chicago! Check out our three posters and one short talk. This is sure to be a fantastic meeting.
We had a wonderful time at our favorite meeting, the SoCal Metabolism Symposium!
March 22, 2025 at 3:39 AM
We had a wonderful time at our favorite meeting, the SoCal Metabolism Symposium!
Bouhaddou x Schmitt Labs picnic. We had a very fun time with our good friends and close collaborators.
March 9, 2025 at 2:12 AM
Bouhaddou x Schmitt Labs picnic. We had a very fun time with our good friends and close collaborators.
The Schmitt lab is standing up for science in Los Angeles today!
March 7, 2025 at 8:47 PM
The Schmitt lab is standing up for science in Los Angeles today!
The Schmitt Lab will be standing up for science this Friday
LA scientists and supporters! Please share - our local Stand Up For Science event is at noon, 3/7 at the Wilshire Federal Building. @latimes.com @laist.com
March 4, 2025 at 8:46 PM
The Schmitt Lab will be standing up for science this Friday
🥳First Paper!🔬 We introduce Malibu, a cpEGFP-based biosensor for malonyl-CoA 🌊🌅. We also demonstrate utility of Malibu in both E. coli and HeLa cells. pubs.acs.org/doi/10.1021/...
A Genetically Encoded Fluorescent Biosensor for Intracellular Measurement of Malonyl-CoA
Malonyl-CoA is the essential building block of fatty acids and regulates cell function through protein malonylation and allosteric regulation of signaling networks. Accordingly, the production and use...
pubs.acs.org
December 19, 2024 at 2:53 AM
🥳First Paper!🔬 We introduce Malibu, a cpEGFP-based biosensor for malonyl-CoA 🌊🌅. We also demonstrate utility of Malibu in both E. coli and HeLa cells. pubs.acs.org/doi/10.1021/...