Charlie Scarff
@scarfflab.bsky.social
Structural Biologist @AstburyCentre @LICAMM University of Leeds
#Myosin #Muscle #Cardiomyopathy #cryoEM #MassSpectrometry
Opinions my own
#Myosin #Muscle #Cardiomyopathy #cryoEM #MassSpectrometry
Opinions my own
PhD studentship available - great collaborative project with @antoncalabrese.bsky.social and Prof. Sarah Harris, Sheffield
Unravelling the mechanisms of cardiac myosin function in health and disease at University of Leeds on FindAPhD.com
PhD Project - Unravelling the mechanisms of cardiac myosin function in health and disease at University of Leeds, listed on FindAPhD.com
eur03.safelinks.protection.outlook.com
November 7, 2025 at 9:54 AM
PhD studentship available - great collaborative project with @antoncalabrese.bsky.social and Prof. Sarah Harris, Sheffield
3.5 yr funded PhD studentship available in my lab October start. Exploring cardiac myosin modulators with cryoEM and mass spec. Get in touch if interested. Apply before 28th July. www.findaphd.com/phds/project...
Unravelling the mechanisms of action of cardiac myosin modulators in health and heart disease at University of Leeds on FindAPhD.com
PhD Project - Unravelling the mechanisms of action of cardiac myosin modulators in health and heart disease at University of Leeds, listed on FindAPhD.com
www.findaphd.com
June 16, 2025 at 6:54 PM
3.5 yr funded PhD studentship available in my lab October start. Exploring cardiac myosin modulators with cryoEM and mass spec. Get in touch if interested. Apply before 28th July. www.findaphd.com/phds/project...
Reposted by Charlie Scarff
Exciting to see our time-resolved #cryoEM device developed by @stemuench.bsky.social & colleagues in action at the CCPEM Spring Symposium!
Brilliant talk by @scarfflab.bsky.social showing how it helped to visualize the elusive actomyosin primed complex & demonstrate the swinging lever mechanism.
Brilliant talk by @scarfflab.bsky.social showing how it helped to visualize the elusive actomyosin primed complex & demonstrate the swinging lever mechanism.
April 25, 2025 at 4:40 PM
Exciting to see our time-resolved #cryoEM device developed by @stemuench.bsky.social & colleagues in action at the CCPEM Spring Symposium!
Brilliant talk by @scarfflab.bsky.social showing how it helped to visualize the elusive actomyosin primed complex & demonstrate the swinging lever mechanism.
Brilliant talk by @scarfflab.bsky.social showing how it helped to visualize the elusive actomyosin primed complex & demonstrate the swinging lever mechanism.
Swinging lever mechanism of myosin shown by time-resolved cryoEM www.nature.com/articles/s41... so glad to finally be able to share this with the community! @astburycentre.bsky.social @astbury-bsl.bsky.social @stemuench.bsky.social @snmcmillan.bsky.social @davidklebl.bsky.social
Swinging lever mechanism of myosin directly shown by time-resolved cryo-EM - Nature
A study using time-resolved cryogenic electron microscopy reveals the swinging lever mechanism of myosin, providing information on the molecular basis behind the production of force and movement by my...
www.nature.com
April 9, 2025 at 5:19 PM
Swinging lever mechanism of myosin shown by time-resolved cryoEM www.nature.com/articles/s41... so glad to finally be able to share this with the community! @astburycentre.bsky.social @astbury-bsl.bsky.social @stemuench.bsky.social @snmcmillan.bsky.social @davidklebl.bsky.social
Mechanism of mavacamten inhibition of myosin - check out our preprint here: www.biorxiv.org/content/10.1...
Mavacamten inhibits myosin activity by stabilising the myosin interacting-heads motif and stalling motor force generation
Most sudden cardiac deaths in young people arise from hypertrophic cardiomyopathy, a genetic disease of the heart muscle, with many causative mutations found in the molecular motor beta-cardiac myosin...
www.biorxiv.org
February 17, 2025 at 8:03 PM
Mechanism of mavacamten inhibition of myosin - check out our preprint here: www.biorxiv.org/content/10.1...
Having a wonderful time in Japan at the Institute for Protein Research, Osaka Uni International Conference. Fascinating and diverse protein research. Thank you!
January 17, 2025 at 3:01 AM
Having a wonderful time in Japan at the Institute for Protein Research, Osaka Uni International Conference. Fascinating and diverse protein research. Thank you!
Reposted by Charlie Scarff
www.findaphd.com/phds/project...
Interested in smooth muscle contraction and wanting to study for a PhD? Project at #UniversityofLeeds #AstburyCentre Apply by 5th Jan!
Interested in smooth muscle contraction and wanting to study for a PhD? Project at #UniversityofLeeds #AstburyCentre Apply by 5th Jan!
Making and breaking myosin filaments: How smooth muscle cells modulate their contractile behaviour. at University of Leeds on FindAPhD.com
PhD Project - Making and breaking myosin filaments: How smooth muscle cells modulate their contractile behaviour. at University of Leeds, listed on FindAPhD.com
www.findaphd.com
November 19, 2024 at 12:01 PM
www.findaphd.com/phds/project...
Interested in smooth muscle contraction and wanting to study for a PhD? Project at #UniversityofLeeds #AstburyCentre Apply by 5th Jan!
Interested in smooth muscle contraction and wanting to study for a PhD? Project at #UniversityofLeeds #AstburyCentre Apply by 5th Jan!
Reposted by Charlie Scarff
PhD studentship available! #AstburyCentre CryoEM & MD simulation to understand cardiac muscle function in health and disease Apply by 5th Jan www.findaphd.com/phds/project...
Unravelling the mechanisms of cardiac myosin function in health and disease through molecular dynamic simulation and electron microscopy at University of Leeds on FindAPhD.com
PhD Project - Unravelling the mechanisms of cardiac myosin function in health and disease through molecular dynamic simulation and electron microscopy at University of Leeds, listed on FindAPhD.com
www.findaphd.com
November 19, 2024 at 12:03 PM
PhD studentship available! #AstburyCentre CryoEM & MD simulation to understand cardiac muscle function in health and disease Apply by 5th Jan www.findaphd.com/phds/project...
PhD studentship available! #AstburyCentre CryoEM & MD simulation to understand cardiac muscle function in health and disease Apply by 5th Jan www.findaphd.com/phds/project...
Unravelling the mechanisms of cardiac myosin function in health and disease through molecular dynamic simulation and electron microscopy at University of Leeds on FindAPhD.com
PhD Project - Unravelling the mechanisms of cardiac myosin function in health and disease through molecular dynamic simulation and electron microscopy at University of Leeds, listed on FindAPhD.com
www.findaphd.com
November 19, 2024 at 12:03 PM
PhD studentship available! #AstburyCentre CryoEM & MD simulation to understand cardiac muscle function in health and disease Apply by 5th Jan www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
Interested in smooth muscle contraction and wanting to study for a PhD? Project at #UniversityofLeeds #AstburyCentre Apply by 5th Jan!
Interested in smooth muscle contraction and wanting to study for a PhD? Project at #UniversityofLeeds #AstburyCentre Apply by 5th Jan!
Making and breaking myosin filaments: How smooth muscle cells modulate their contractile behaviour. at University of Leeds on FindAPhD.com
PhD Project - Making and breaking myosin filaments: How smooth muscle cells modulate their contractile behaviour. at University of Leeds, listed on FindAPhD.com
www.findaphd.com
November 19, 2024 at 12:01 PM
www.findaphd.com/phds/project...
Interested in smooth muscle contraction and wanting to study for a PhD? Project at #UniversityofLeeds #AstburyCentre Apply by 5th Jan!
Interested in smooth muscle contraction and wanting to study for a PhD? Project at #UniversityofLeeds #AstburyCentre Apply by 5th Jan!
4 Cheney PhD scholarships available in in situ structural biology - bench to bedside
@ScienceLeeds
@Astbury_BSL
@LeedsBRC
@LeedsMedHealth
@AstburyCentre
astbury.leeds.ac.uk/cheney-phd apply by 3rd December
@ScienceLeeds
@Astbury_BSL
@LeedsBRC
@LeedsMedHealth
@AstburyCentre
astbury.leeds.ac.uk/cheney-phd apply by 3rd December
Cheney PhD : The Astbury Centre for Structural Molecular Biology
The Cheney Scholarship 4-year PhD Scheme in in situ structural biology Applications are now invited for up to 4 new scholarships, commencing in October 2025. The application deadline is Tuesday 3rd De...
astbury.leeds.ac.uk
November 13, 2024 at 10:10 AM
4 Cheney PhD scholarships available in in situ structural biology - bench to bedside
@ScienceLeeds
@Astbury_BSL
@LeedsBRC
@LeedsMedHealth
@AstburyCentre
astbury.leeds.ac.uk/cheney-phd apply by 3rd December
@ScienceLeeds
@Astbury_BSL
@LeedsBRC
@LeedsMedHealth
@AstburyCentre
astbury.leeds.ac.uk/cheney-phd apply by 3rd December
Do you work in the life sciences sector & are interested in "Taking drug discovery towards cells and tissue – How can this drive translation?" Join
@AstburyCentre
for a 1-day meeting on 4th Apr 25 at the Royal Society for a day of talks, networking, & more astburyopeninnovation2025.eventbrite.com
@AstburyCentre
for a 1-day meeting on 4th Apr 25 at the Royal Society for a day of talks, networking, & more astburyopeninnovation2025.eventbrite.com
Taking drug discovery towards cells and tissues - Register interest
Join the Astbury Centre for a day focused on taking drug discovery into cells and tissues with the aim of driving translation.
astburyopeninnovation2025.eventbrite.com
November 13, 2024 at 10:08 AM
Do you work in the life sciences sector & are interested in "Taking drug discovery towards cells and tissue – How can this drive translation?" Join
@AstburyCentre
for a 1-day meeting on 4th Apr 25 at the Royal Society for a day of talks, networking, & more astburyopeninnovation2025.eventbrite.com
@AstburyCentre
for a 1-day meeting on 4th Apr 25 at the Royal Society for a day of talks, networking, & more astburyopeninnovation2025.eventbrite.com
Interested in how myosin generates movement? and how actin activates it? Check out our preprint: biorxiv.org/content/10.1...
@UoL_LICAMM
@AstburyCentre
Beautiful collaborative effort!!
@UoL_LICAMM
@AstburyCentre
Beautiful collaborative effort!!
Swinging lever mechanism of myosin directly demonstrated by time-resolved cryoEM
Myosins are essential for producing force and movement in cells through their interactions with F-actin. Generation of movement is proposed to occur through structural changes within the myosin motor ...
biorxiv.org
November 13, 2024 at 10:07 AM
Interested in how myosin generates movement? and how actin activates it? Check out our preprint: biorxiv.org/content/10.1...
@UoL_LICAMM
@AstburyCentre
Beautiful collaborative effort!!
@UoL_LICAMM
@AstburyCentre
Beautiful collaborative effort!!