Rough Diamonds
@sarahconstantin.skystack.xyz
Underrated opportunities in science, technology, and society
This is an automated Substack Account of https://sarahconstantin.substack.com
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This is an automated Substack Account of https://sarahconstantin.substack.com
Discover more/Create at: @skystack.xyz
Biotech Startup Stats • What predicts success or failure?
Biotech Startup Stats
What predicts success or failure?
sarahconstantin.substack.com
February 5, 2026 at 8:41 PM
Biotech Startup Stats • What predicts success or failure?
Cancer-Selective, Pan-Essential Targets from DepMap • A Claude Code experiment
Cancer-Selective, Pan-Essential Targets from DepMap
A Claude Code experiment
sarahconstantin.substack.com
February 5, 2026 at 8:41 PM
Cancer-Selective, Pan-Essential Targets from DepMap • A Claude Code experiment
Self-Help Tactics That Are Working For Me • A little navel-gazing, as a treat
Self-Help Tactics That Are Working For Me
A little navel-gazing, as a treat
sarahconstantin.substack.com
February 5, 2026 at 8:41 PM
Self-Help Tactics That Are Working For Me • A little navel-gazing, as a treat
Measuring Drug Target Success • A data analysis experiment
Measuring Drug Target Success
A data analysis experiment
sarahconstantin.substack.com
February 5, 2026 at 8:41 PM
Measuring Drug Target Success • A data analysis experiment
Making Sense of Consciousness Part 8: Summing Up • What did we learn with all this?
Making Sense of Consciousness Part 8: Summing Up
What did we learn with all this?
sarahconstantin.substack.com
February 5, 2026 at 8:41 PM
Making Sense of Consciousness Part 8: Summing Up • What did we learn with all this?
Making Sense of Consciousness Part 7: Volition • When do we perceive actions as our own?
Making Sense of Consciousness Part 7: Volition
When do we perceive actions as our own?
sarahconstantin.substack.com
February 5, 2026 at 8:41 PM
Making Sense of Consciousness Part 7: Volition • When do we perceive actions as our own?
SS26 Color Stats • It's that time of year again
SS26 Color Stats
It's that time of year again
sarahconstantin.substack.com
February 5, 2026 at 8:41 PM
SS26 Color Stats • It's that time of year again
Making Sense of Consciousness Part 6: Perceptions of Disembodiment • What makes us feel like we're "in our own body" vs not?
Making Sense of Consciousness Part 6: Perceptions of Disembodiment
What makes us feel like we're "in our own body" vs not?
sarahconstantin.substack.com
February 5, 2026 at 8:41 PM
Making Sense of Consciousness Part 6: Perceptions of Disembodiment • What makes us feel like we're "in our own body" vs not?
Making Sense of Consciousness Part 5: Consciousness and the Self • The sense of an "I"
Making Sense of Consciousness Part 5: Consciousness and the Self
The sense of an "I"
sarahconstantin.substack.com
February 5, 2026 at 8:41 PM
Making Sense of Consciousness Part 5: Consciousness and the Self • The sense of an "I"
I Vibecoded a Dispute Resolution App • What I learned from noodling around with Claude
I Vibecoded a Dispute Resolution App
What I learned from noodling around with Claude
sarahconstantin.substack.com
February 5, 2026 at 8:41 PM
I Vibecoded a Dispute Resolution App • What I learned from noodling around with Claude
Making Sense of Consciousness Part 4: States of Consciousness • waking, sleeping, anaesthesia, coma, and other "states of consciousness"
Making Sense of Consciousness Part 4: States of Consciousness
waking, sleeping, anaesthesia, coma, and other "states of consciousness"
sarahconstantin.substack.com
February 5, 2026 at 8:41 PM
Making Sense of Consciousness Part 4: States of Consciousness • waking, sleeping, anaesthesia, coma, and other "states of consciousness"
Making Sense of Consciousness Part 3: The Pulvinar Nucleus • a neuroscience shaggy dog story
Making Sense of Consciousness Part 3: The Pulvinar Nucleus
a neuroscience shaggy dog story
sarahconstantin.substack.com
February 5, 2026 at 8:41 PM
Making Sense of Consciousness Part 3: The Pulvinar Nucleus • a neuroscience shaggy dog story
Making Sense of Consciousness Part 2: Attention • The difference between what we notice and what we don't
Making Sense of Consciousness Part 2: Attention
The difference between what we notice and what we don't
sarahconstantin.substack.com
February 5, 2026 at 8:41 PM
Making Sense of Consciousness Part 2: Attention • The difference between what we notice and what we don't
Making Sense of Consciousness Part 1: Perceptual Awareness • a noob reads neuro
Making Sense of Consciousness Part 1: Perceptual Awareness
a noob reads neuro
sarahconstantin.substack.com
February 5, 2026 at 8:41 PM
Making Sense of Consciousness Part 1: Perceptual Awareness • a noob reads neuro
Tech for Thinking • who's working on it? and seriously, can we come up with a better name?
Tech for Thinking
who's working on it? and seriously, can we come up with a better name?
sarahconstantin.substack.com
February 5, 2026 at 8:41 PM
Tech for Thinking • who's working on it? and seriously, can we come up with a better name?
Broad-Spectrum Cancer Treatments • A proposal for a research program
Broad-Spectrum Cancer Treatments
A proposal for a research program
sarahconstantin.substack.com
February 5, 2026 at 8:41 PM
Broad-Spectrum Cancer Treatments • A proposal for a research program
Who's Working On It? AI-Controlled Experiments • A real "AI Scientist" would generate new data
Who's Working On It? AI-Controlled Experiments
A real "AI Scientist" would generate new data
sarahconstantin.substack.com
February 5, 2026 at 8:41 PM
Who's Working On It? AI-Controlled Experiments • A real "AI Scientist" would generate new data
The Uses of Complacency • The optimal amount of self-satisfaction is not zero
The Uses of Complacency
The optimal amount of self-satisfaction is not zero
sarahconstantin.substack.com
February 5, 2026 at 8:41 PM
The Uses of Complacency • The optimal amount of self-satisfaction is not zero
Prodromes and Biomarkers in Chronic Disease • Can we treat the "untreatable" by catching it before it's diagnosed?
Prodromes and Biomarkers in Chronic Disease
Can we treat the "untreatable" by catching it before it's diagnosed?
sarahconstantin.substack.com
February 5, 2026 at 8:41 PM
Prodromes and Biomarkers in Chronic Disease • Can we treat the "untreatable" by catching it before it's diagnosed?
FW25 Color Stats • Another season, another reason, for counting colors
FW25 Color Stats
Another season, another reason, for counting colors
sarahconstantin.substack.com
February 5, 2026 at 8:41 PM
FW25 Color Stats • Another season, another reason, for counting colors
AI "Deep Research" Tools Reviewed • How do they stack up?
AI "Deep Research" Tools Reviewed
How do they stack up?
sarahconstantin.substack.com
February 5, 2026 at 8:41 PM
AI "Deep Research" Tools Reviewed • How do they stack up?
Book Review: Affective Neuroscience • What rats can tell us about feelings
Book Review: Affective Neuroscience
What rats can tell us about feelings
sarahconstantin.substack.com
February 5, 2026 at 8:41 PM
Book Review: Affective Neuroscience • What rats can tell us about feelings
What's Behind the SynBio Bust? • And what lessons can we learn?
What's Behind the SynBio Bust?
And what lessons can we learn?
sarahconstantin.substack.com
February 5, 2026 at 8:41 PM
What's Behind the SynBio Bust? • And what lessons can we learn?
What Goes Without Saying • a little rant
What Goes Without Saying
a little rant
sarahconstantin.substack.com
February 5, 2026 at 8:41 PM
What Goes Without Saying • a little rant