Wellcome Sanger Institute
LightNews LightNews
banner
sangerinstitute.bsky.social
Wellcome Sanger Institute
@sangerinstitute.bsky.social
3.3K followers 94 following 200 posts
We are a world leader in genomics research. We apply and explore genomic technologies to advance the understanding of biology and improve health 🧬
https://www.sanger.ac.uk/
Posts Replies Media Videos
sangerinstitute.bsky.social
Read ‘A non-canonical lymphoblast in refractory childhood T-cell leukaemia’ from @sangerinstitute.bsky.social, @cuh.nhs.uk, @greatormondst.bsky.social, @ucl.ac.uk and others in @natcomms.nature.com, here ⤵️

www.nature.com/articles/s41...
A non-canonical lymphoblast in refractory childhood T-cell leukaemia - Nature Communications
T-cell acute lymphoblastic leukemia is a highly aggressive disease with varying recurrence rates. Here, the authors build a single cell transcriptomic atlas of childhood T-cell acute lymphoblastic leu...
www.nature.com
November 12, 2025 at 10:37 AM
sangerinstitute.bsky.social
Three-year-old Jacob was diagnosed with T-ALL leukaemia in December 2024 and is now in remission.

Find out more about his story here ⤵️

www.sanger.ac.uk/news_item/my...
Jacob is sitting on the grass smiling, wearing a smiley face cap and patterned outfit. He has a bandage on his cheek, holding in a nose tube, and holds pink shoes.
November 12, 2025 at 10:37 AM
sangerinstitute.bsky.social
David’s pioneering work at @sangerinstitute.bsky.social is helping uncover the genetic drivers of skin cancer and opening new doors for treatment. 🧬

Read more about David’s work here ⤵️
sangerinstitute.blog/2024/11/12/u...
Unlocking the genetics of skin cancer - Wellcome Sanger Institute Blog
Dr David Adams, Senior Group Leader at the Wellcome Sanger Institute, is a pioneer in cancer biology and uncovering skin cancer genetics. We explore his 20-year career at Sanger and the global impact ...
sangerinstitute.blog
November 10, 2025 at 10:59 AM
sangerinstitute.bsky.social
The team at @sangerinstitute.bsky.social and the International Agency for Research on Cancer (IARC) will combine genomics, microbiome science and global collaboration to uncover causes of early onset bowel cancer, which may lead to preventative strategies in the future.
Alt Text: Image shows quote card with Professor Sir Mike Stratton standing in front of a brown background and text on the left reads: “The rise in early-onset bowel cancer is one of the most urgent conundrums in modern medicine. This grant will enable us to combine cutting-edge genomic and microbiome research to uncover its causes and ultimately, help develop strategies to prevent it.”
November 6, 2025 at 3:16 PM
sangerinstitute.bsky.social
Read ‘Basic reproduction number varies markedly between closely related pandemic Escherichia coli clones’ from @sangerinstitute.bsky.social, @aalto.fi in Finland, University of Oslo and their collaborators in @natcomms.nature.com here: www.nature.com/articles/s41...
Basic reproduction number varies markedly between closely related pandemic Escherichia coli clones - Nature Communications
Authors introduce an epidemiological model to estimate the basic reproduction number (R0) for multiple E. coli genotypes and find that some have comparable transmissibility to pandemic H1N1 while othe...
www.nature.com
November 4, 2025 at 11:55 AM
sangerinstitute.bsky.social
Read ‘Basic reproduction number varies markedly between closely related pandemic Escherichia coli clones’ from @SangerInstitute, @aalto.fi in Finland, University of Oslo and their collaborators in @natcomms.nature.com here:
https://www.nature.com/articles/s41467-025-65301-1
Basic reproduction number varies markedly between closely related pandemic Escherichia coli clones
Nature Communications - Authors introduce an epidemiological model to estimate the basic reproduction number (R0) for multiple E. coli genotypes and find that some have comparable transmissibility...
www.nature.com
November 4, 2025 at 11:51 AM
sangerinstitute.bsky.social
Read ‘Complex de novo structural variants are an underestimated cause of rare disorders’ from @sangerinstitute.bsky.social, @genomicsengland.bsky.social, @cuh.nhs.uk and collaborators in @natcomms.nature.com here:

www.nature.com/articles/s41...
Complex de novo structural variants are an underestimated cause of rare disorders - Nature Communications
De novo structural variants are an important cause of rare disorders but remain poorly understood. Here, the authors analyse over 12,000 families and reveal the prevalence, diversity, and clinical imp...
www.nature.com
November 3, 2025 at 11:05 AM
sangerinstitute.bsky.social
Read ‘Genetic population structure of Haemophilus influenzae at local and global scales’ from @sangerinstitute.bsky.social, the University of Oslo, University of Helsinki, @ox.ac.uk and collaborators in @natmicrobiol.nature.com here: www.nature.com/articles/s41...
Genetic population structure of Haemophilus influenzae at local and global scales - Nature Microbiology
Large-scale sequencing and population genomic analyses reveal frequent transmission, a highly admixed global population structure and evidence of pervasive negative selection in Haemophilus influenzae...
www.nature.com
October 31, 2025 at 10:55 AM
sangerinstitute.bsky.social
Thanks to @petrathepostdoc.bsky.social for the great visual! 👏
October 24, 2025 at 9:21 AM
sangerinstitute.bsky.social
Read 'Ancient origin of an urban underground mosquito' by @sangerinstitute.bsky.social and @princeton.edu in @science.org here ⤵️
www.science.org/doi/10.1126/...
Ancient origin of an urban underground mosquito
Understanding how life is adapting to urban environments represents an important challenge in evolutionary biology. In this work, we investigate a widely cited example of urban adaptation, Culex pipie...
www.science.org
October 24, 2025 at 9:09 AM