SandkvistLab
@sandkvistlab.bsky.social
Reposted by SandkvistLab
www.ahajournals.org/doi/10.1161/... @drbadbug.bsky.social A role for FXII in responding to bac. infection & suggests that by inhibiting the contact & KKSs & impairing neutrophil activation, CpaA may blunt the innate immune response/help prevent the elimination of A baumannii from the human host.
Acinetobacter Baumannii Secreted Protease CpaA Inhibits Factor XII-Mediated Bradykinin Generation and Neutrophil Activation | Circulation Research
BACKGROUND: FXII (coagulation factor XII) is best known for its roles in the contact and kallikrein-kinin
pathways. FXII is converted to its active enzyme (FXIIa [activated factor XII]) by
PKa (plasma...
www.ahajournals.org
May 20, 2025 at 11:23 AM
www.ahajournals.org/doi/10.1161/... @drbadbug.bsky.social A role for FXII in responding to bac. infection & suggests that by inhibiting the contact & KKSs & impairing neutrophil activation, CpaA may blunt the innate immune response/help prevent the elimination of A baumannii from the human host.