Professor of Immunology @CNIC, Madrid, Spain. https://www.cnic.es/en/investigacion/immunobiology
🙏🏻collab #CNIC_CARDIO, #Borjaibanez1 starting this with me 7 years ago, Valentin Fuster, Fredrik Bäckhed on all ImP work, Göran Bergström IGT cohort, Kostas Stellos, Gabriel Nuñez Coral Barbas & many other col.
🙏🏻collab #CNIC_CARDIO, #Borjaibanez1 starting this with me 7 years ago, Valentin Fuster, Fredrik Bäckhed on all ImP work, Göran Bergström IGT cohort, Kostas Stellos, Gabriel Nuñez Coral Barbas & many other col.
📉 Its effects are lipid-independent: ImP–I1R–mTOR axis in myeloid cells as a new therapeutic target for atherosclerosis. Synergy with lipid-lowering therapy?
#immunosky #cardiosky
📉 Its effects are lipid-independent: ImP–I1R–mTOR axis in myeloid cells as a new therapeutic target for atherosclerosis. Synergy with lipid-lowering therapy?
#immunosky #cardiosky
🧬 Genetic or pharmacological blockade of I1R prevents #atherosclerosis development without lowering cholesterol.
#immunosky #cardiosky #microbiomesky
🧬 Genetic or pharmacological blockade of I1R prevents #atherosclerosis development without lowering cholesterol.
#immunosky #cardiosky #microbiomesky
🧪 It triggers #innate and #adaptive #immune activation and systemic inflammation.
#immunosky #cardiosky #microbiomesky
🧪 It triggers #innate and #adaptive #immune activation and systemic inflammation.
#immunosky #cardiosky #microbiomesky
#immunosky #cardiosky #microbiomesky
#immunosky #cardiosky #microbiomesky
🦠 ImP concentration depend on gut #microbiota composition.
#immunosky #cardiosky #microbiomesky
🦠 ImP concentration depend on gut #microbiota composition.
#immunosky #cardiosky #microbiomesky
🙏🏻collaborators @cicbiomagune.bsky.social, @ciml.bsky.social, @washumedicine.bsky.social
🙏🏻#Fundación La Caixa @ageinves.bsky.social @comunidadmadrid.bsky.social @contracancerinv.bsky.social @worldwidecancer.bsky.social
#immunotherapy #immunosky #cardiosky
🙏🏻collaborators @cicbiomagune.bsky.social, @ciml.bsky.social, @washumedicine.bsky.social
🙏🏻#Fundación La Caixa @ageinves.bsky.social @comunidadmadrid.bsky.social @contracancerinv.bsky.social @worldwidecancer.bsky.social
#immunotherapy #immunosky #cardiosky
✔️ cDC1s promote atherosclerosis via STING-driven IL-12 boost of Th1 & CD8+ T cell immunity
✔️ Targeted immunosuppression of cDC1s reduces inflammation and plaques
🧠 Novel precision strategy to tackle atherosclerosis beyond lipid control
#CardioImmunology #immunosky #cardiosky
✔️ cDC1s promote atherosclerosis via STING-driven IL-12 boost of Th1 & CD8+ T cell immunity
✔️ Targeted immunosuppression of cDC1s reduces inflammation and plaques
🧠 Novel precision strategy to tackle atherosclerosis beyond lipid control
#CardioImmunology #immunosky #cardiosky
Anti-CLEC9A-dexamethasone NPs:
⬇️ Th1 CD4+
⬇️ Cytotoxic CD8+
⏸️ No effect on Tregs or Th17
🦠 Preserve acute antiviral immunity (tested in influenza infection)
➡️ Specific immunomodulation of cDC1s without global immunosuppression!
#immunosky #cardiosky
Anti-CLEC9A-dexamethasone NPs:
⬇️ Th1 CD4+
⬇️ Cytotoxic CD8+
⏸️ No effect on Tregs or Th17
🦠 Preserve acute antiviral immunity (tested in influenza infection)
➡️ Specific immunomodulation of cDC1s without global immunosuppression!
#immunosky #cardiosky
Nanoparticles (NPs) decorated with anti-CLEC9A (cDC1-specific) and loaded with dexamethasone.
🎯 Target cDC1s with high specificity
📉 Reduce lesion size
🧾 No changes in lipid profile
🛡️ No toxicity to liver or kidneys
#NanoImmunotherapy #immunosky #cardiosky
Nanoparticles (NPs) decorated with anti-CLEC9A (cDC1-specific) and loaded with dexamethasone.
🎯 Target cDC1s with high specificity
📉 Reduce lesion size
🧾 No changes in lipid profile
🛡️ No toxicity to liver or kidneys
#NanoImmunotherapy #immunosky #cardiosky
We found that STING signaling in cDC1s is required for their pro-atherogenic role.
STING-deficient cDC1s =
🧬 Fewer plaques
⬇️ CD4+ Th1 and CD8+ IFN-γ+ T cells
🧠 STING is a crucial upstream driver in cDC1-mediated inflammation
#immunosky #cardiosky
We found that STING signaling in cDC1s is required for their pro-atherogenic role.
STING-deficient cDC1s =
🧬 Fewer plaques
⬇️ CD4+ Th1 and CD8+ IFN-γ+ T cells
🧠 STING is a crucial upstream driver in cDC1-mediated inflammation
#immunosky #cardiosky
⬇️ Th1 and CD8+ IFN-γ+ T cells in the absence of cDC1s
⬇️ IL-12 expression
🧬 ↓ T cell clonality in CD4+ Th1 and CD8+ cytotoxic subsets
💡 cDC1s fuel local and systemic pro-inflammatory T cell responses
#immunosky #cardiosky
⬇️ Th1 and CD8+ IFN-γ+ T cells in the absence of cDC1s
⬇️ IL-12 expression
🧬 ↓ T cell clonality in CD4+ Th1 and CD8+ cytotoxic subsets
💡 cDC1s fuel local and systemic pro-inflammatory T cell responses
#immunosky #cardiosky
Fewer CD3+ T cells in aorta
No changes in cholesterol-body weight
➡️ cDC1s promote atherogenesis independent of lipid metabolism
#immunosky #cardiosky
Fewer CD3+ T cells in aorta
No changes in cholesterol-body weight
➡️ cDC1s promote atherogenesis independent of lipid metabolism
#immunosky #cardiosky
➡️ increased atherosclerosis. This effect disappears when cDC1s are depleted (Xcr1Cre-DTA BM graft in Ldlr⁻/⁻ mice).
➡️cDC1s are required for lesion expansion upon FLT3L administration.
#ImmunoCardio #immunosky #cardiosky
➡️ increased atherosclerosis. This effect disappears when cDC1s are depleted (Xcr1Cre-DTA BM graft in Ldlr⁻/⁻ mice).
➡️cDC1s are required for lesion expansion upon FLT3L administration.
#ImmunoCardio #immunosky #cardiosky
Type 1 dendritic cells (cDC1s) promote atherogenic immunity & can be targeted with tolerogenic nanoparticles.
🔗 doi.org/10.1161/CIRC...
#Immunotherapy #Atherosclerosis #Nanomedicine
#CNIC_CARDIO #immunosky #cardiosky
Type 1 dendritic cells (cDC1s) promote atherogenic immunity & can be targeted with tolerogenic nanoparticles.
🔗 doi.org/10.1161/CIRC...
#Immunotherapy #Atherosclerosis #Nanomedicine
#CNIC_CARDIO #immunosky #cardiosky
Thx thesis commitee: Julián Aragonés, Arantxa Cruz-Adalia & Bart Everts on wonderful discussion and visit!
Thx Gillian Dunphy @gilliandunphy.bsky.social on fantastic co-supervision!!!
Thx thesis commitee: Julián Aragonés, Arantxa Cruz-Adalia & Bart Everts on wonderful discussion and visit!
Thx Gillian Dunphy @gilliandunphy.bsky.social on fantastic co-supervision!!!
#immunosky #cancersky (6/7)
#immunosky #cancersky (6/7)
#immunosky #cancersky (5/7)
#immunosky #cancersky (5/7)
#immunosky #cancersky (4/7)
#immunosky #cancersky (4/7)
#immunosky #cancersky (3/7)
#immunosky #cancersky (3/7)
#immunosky #cancersky (2/7)
#immunosky #cancersky (2/7)
sciety.org/articles/act...
sciety.org/articles/act...
Thx to support by #SEI (Spanish society for immunology), Inmunotek @miltenyibiotec.bsky.social @embo.org @efis-immunology.bsky.social @eurjimmunol.bsky.social
Thx to support by #SEI (Spanish society for immunology), Inmunotek @miltenyibiotec.bsky.social @embo.org @efis-immunology.bsky.social @eurjimmunol.bsky.social