Samuel Tingle
samjtingle.bsky.social
Samuel Tingle
@samjtingle.bsky.social
Transplant and HPB surgery | Clinical Research Fellow (MRC) in Transplantation | Cochrane Clinical Answers Associate Editor | Past NIHR Academic Clinical Fellow and AFP
April 2, 2025 at 10:16 AM
📊 Bonus: We built an open-source R package + web app for CEUS time-intensity analysis!
Check it out here 👉 stingle.shinyapps.io/Time_intensi...

🔗 Read the full #OpenAccess article in Transplant International: doi.org/10.3389/ti.2...

#Transplantation #KidneyResearch #MachinePerfusion
Frontiers Publishing Partnerships | Contrast-Enhanced Ultrasound to Assess Kidney Quality During Ex Situ Normothermic Machine Perfusion
Normothermic machine perfusion (NMP) provides opportunity for viability assessment of donated kidneys. Diminished microvascular perfusion, despite adequate t...
doi.org
April 2, 2025 at 10:16 AM
💡 Why it matters:

CEUS could provide real-time, objective assessment during NMP—supporting viability decisions at organ assessment and reconditioning centres (ARCs)

❗️But validation in transplanted kidneys is still needed
April 2, 2025 at 10:16 AM
🔑 Key findings from porcine and human kidney models:
1️⃣ Microvascular perfusion at 2h correlated with markers of injury
2️⃣ Total renal blood flow did not
3️⃣ CEUS is safe, non-toxic, & potentially bedside-friendly
April 2, 2025 at 10:16 AM
Thank you for the invitation!
February 20, 2025 at 8:34 PM
Great start!
November 28, 2024 at 7:23 AM
Reposted by Samuel Tingle
Started an HPB surgery starter pack! go.bsky.app/7Z2kqK6 Let’s add to the list! Residents, fellows, attendings, professors 😊
November 12, 2024 at 8:14 PM
November 19, 2024 at 8:53 PM
Full #OpenAccess free article:
jamanetwork.com/journals/jam...

A massive thank you to the full team, supporting institutions, funders, donors and their families 🙏

@georgek-dr.bsky.social @oudt-nhsbt.bsky.social
Donor Time to Death and Kidney Transplant Outcomes
This cohort study assesses whether prolonged donor time to death after withdrawal of life-sustaining-treatment is associated with kidney transplant outcomes.
jamanetwork.com
November 19, 2024 at 8:53 PM
🔑 Time to death was not associated with recipient eGFR, DGF or graft survival

🔑 Compared to a 1 hour stand down policy, the 3 hour minimum wait ⬆️ #DCD transplant by 14%

🔑 Simple and safe change for organ donation organisations globally
November 19, 2024 at 8:53 PM