RyanLab_TCD
@ryanlab.bsky.social
Assistant Professor in Trinity College Dublin. A mitochondria and immunometabolism enthusiast. Views my own. 🇮🇪
📢Last 2 weeks of #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️
biomed.news/bims-imicid/...
biomed.news/bims-imicid/...
Exciting to have a paper in the collection!
An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice
biomed.news/bims-imicid/...
biomed.news/bims-imicid/...
Exciting to have a paper in the collection!
An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice
November 23, 2025 at 1:05 PM
📢Last 2 weeks of #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️
biomed.news/bims-imicid/...
biomed.news/bims-imicid/...
Exciting to have a paper in the collection!
An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice
biomed.news/bims-imicid/...
biomed.news/bims-imicid/...
Exciting to have a paper in the collection!
An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice
Last week's #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting finding:
Intracellular Salmonella hijacks the mitochondrial citrate carrier to evade host oxidative defenses
biomed.news/bims-imicid/...
Interesting finding:
Intracellular Salmonella hijacks the mitochondrial citrate carrier to evade host oxidative defenses
November 10, 2025 at 9:23 AM
Last week's #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting finding:
Intracellular Salmonella hijacks the mitochondrial citrate carrier to evade host oxidative defenses
biomed.news/bims-imicid/...
Interesting finding:
Intracellular Salmonella hijacks the mitochondrial citrate carrier to evade host oxidative defenses
Metabolic environment-driven remodeling of mitochondrial ribosomes regulates translation and biogenesis #mitochondria
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
November 6, 2025 at 5:02 PM
Metabolic environment-driven remodeling of mitochondrial ribosomes regulates translation and biogenesis #mitochondria
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting finding:
Quercetin-derived microbial metabolite DOPAC potentiates CD8+ T cell anti-tumor immunity via NRF2-mediated mitophagy
biomed.news/bims-imicid/...
Interesting finding:
Quercetin-derived microbial metabolite DOPAC potentiates CD8+ T cell anti-tumor immunity via NRF2-mediated mitophagy
November 3, 2025 at 4:27 PM
Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting finding:
Quercetin-derived microbial metabolite DOPAC potentiates CD8+ T cell anti-tumor immunity via NRF2-mediated mitophagy
biomed.news/bims-imicid/...
Interesting finding:
Quercetin-derived microbial metabolite DOPAC potentiates CD8+ T cell anti-tumor immunity via NRF2-mediated mitophagy
📢 last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting finding:
Bioenergetic reprogramming of macrophages reduces drug tolerance in Mycobacterium tuberculosis @NatureComms
biomed.news/bims-imicid/...
Interesting finding:
Bioenergetic reprogramming of macrophages reduces drug tolerance in Mycobacterium tuberculosis @NatureComms
October 28, 2025 at 9:41 AM
📢 last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting finding:
Bioenergetic reprogramming of macrophages reduces drug tolerance in Mycobacterium tuberculosis @NatureComms
biomed.news/bims-imicid/...
Interesting finding:
Bioenergetic reprogramming of macrophages reduces drug tolerance in Mycobacterium tuberculosis @NatureComms
Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Lots of excellent work inside incl.
Backtracking metabolic dynamics in single cells predicts bacterial replication in human macrophages.
biomed.news/bims-imicid/...
Lots of excellent work inside incl.
Backtracking metabolic dynamics in single cells predicts bacterial replication in human macrophages.
October 20, 2025 at 12:27 PM
Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Lots of excellent work inside incl.
Backtracking metabolic dynamics in single cells predicts bacterial replication in human macrophages.
biomed.news/bims-imicid/...
Lots of excellent work inside incl.
Backtracking metabolic dynamics in single cells predicts bacterial replication in human macrophages.
📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Many highlights inside!
incl. TRAF6 integrates innate immune signals to regulate glucose homeostasis via Parkin-dependent and Parkin-independent mitophagy
biomed.news/bims-imicid/...
Many highlights inside!
incl. TRAF6 integrates innate immune signals to regulate glucose homeostasis via Parkin-dependent and Parkin-independent mitophagy
October 12, 2025 at 12:11 PM
📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Many highlights inside!
incl. TRAF6 integrates innate immune signals to regulate glucose homeostasis via Parkin-dependent and Parkin-independent mitophagy
biomed.news/bims-imicid/...
Many highlights inside!
incl. TRAF6 integrates innate immune signals to regulate glucose homeostasis via Parkin-dependent and Parkin-independent mitophagy
📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Highlight:
Acetyl-CoA carboxylase-1 inhibition increases regulatory T-cell metabolism and graft-vs-host disease treatment efficacy via mitochondrial fusion
biomed.news/bims-imicid/...
Highlight:
Acetyl-CoA carboxylase-1 inhibition increases regulatory T-cell metabolism and graft-vs-host disease treatment efficacy via mitochondrial fusion
October 5, 2025 at 9:22 AM
📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Highlight:
Acetyl-CoA carboxylase-1 inhibition increases regulatory T-cell metabolism and graft-vs-host disease treatment efficacy via mitochondrial fusion
biomed.news/bims-imicid/...
Highlight:
Acetyl-CoA carboxylase-1 inhibition increases regulatory T-cell metabolism and graft-vs-host disease treatment efficacy via mitochondrial fusion
Recently @natureportfolio.nature.com had an article about Bluesky being a better platform for sharing science than X. It hasn't been my experience to date. Same post yesterday had more engagement on X and LinkedIN. Wondering if it's domain specific? What are others experience?
September 29, 2025 at 8:20 AM
Recently @natureportfolio.nature.com had an article about Bluesky being a better platform for sharing science than X. It hasn't been my experience to date. Same post yesterday had more engagement on X and LinkedIN. Wondering if it's domain specific? What are others experience?
📢Last weeks #immunometabolism discoveries
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Highlights:
Intra-tumoral hypoxia promotes CD8+ T cell dysfunction via chronic activation of integrated stress response transcription factor ATF4.
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Highlights:
Intra-tumoral hypoxia promotes CD8+ T cell dysfunction via chronic activation of integrated stress response transcription factor ATF4.
September 28, 2025 at 8:42 AM
📢Last weeks #immunometabolism discoveries
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Highlights:
Intra-tumoral hypoxia promotes CD8+ T cell dysfunction via chronic activation of integrated stress response transcription factor ATF4.
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Highlights:
Intra-tumoral hypoxia promotes CD8+ T cell dysfunction via chronic activation of integrated stress response transcription factor ATF4.
New cohort of @tcddublin.bsky.social Assitant Professors at our induction😀☘️
September 17, 2025 at 10:10 AM
New cohort of @tcddublin.bsky.social Assitant Professors at our induction😀☘️
🔉Last weeks #immunometabolism discoveries @biomednews.bsky.social 🔽🔽🔽
biomed.news/bims-imicid/...
Highlight:
Macrophage metabolic reprogramming during dietary stress influences adult body size in Drosophila
biomed.news/bims-imicid/...
Highlight:
Macrophage metabolic reprogramming during dietary stress influences adult body size in Drosophila
September 15, 2025 at 11:54 AM
🔉Last weeks #immunometabolism discoveries @biomednews.bsky.social 🔽🔽🔽
biomed.news/bims-imicid/...
Highlight:
Macrophage metabolic reprogramming during dietary stress influences adult body size in Drosophila
biomed.news/bims-imicid/...
Highlight:
Macrophage metabolic reprogramming during dietary stress influences adult body size in Drosophila
📢Last 2 weeks of #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
biomed.news/bims-imicid/...
Highlight:
Nrf2 drives activation-driven expansion of CD4+T cells by modulating glucose and glutamine metabolism
biomed.news/bims-imicid/...
biomed.news/bims-imicid/...
Highlight:
Nrf2 drives activation-driven expansion of CD4+T cells by modulating glucose and glutamine metabolism
September 10, 2025 at 7:50 AM
📢Last 2 weeks of #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
biomed.news/bims-imicid/...
Highlight:
Nrf2 drives activation-driven expansion of CD4+T cells by modulating glucose and glutamine metabolism
biomed.news/bims-imicid/...
biomed.news/bims-imicid/...
Highlight:
Nrf2 drives activation-driven expansion of CD4+T cells by modulating glucose and glutamine metabolism
📢Last 2 weeks #immunometabolism discoveries
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
biomed.news/bims-imicid/...
Highlights:
Species-specific serine metabolism differentially controls natural killer cell functions
nature.com/articles/s42...
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
biomed.news/bims-imicid/...
Highlights:
Species-specific serine metabolism differentially controls natural killer cell functions
nature.com/articles/s42...
August 27, 2025 at 10:48 PM
📢Last 2 weeks #immunometabolism discoveries
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
biomed.news/bims-imicid/...
Highlights:
Species-specific serine metabolism differentially controls natural killer cell functions
nature.com/articles/s42...
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
biomed.news/bims-imicid/...
Highlights:
Species-specific serine metabolism differentially controls natural killer cell functions
nature.com/articles/s42...
📢Last weeks #immunometabolism discoveries
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Highlights:
I) Glucose-dependent glycosphingolipid biosynthesis fuels CD8+ T cell function and tumor control - cell.com/cell-metabol...
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Highlights:
I) Glucose-dependent glycosphingolipid biosynthesis fuels CD8+ T cell function and tumor control - cell.com/cell-metabol...
August 11, 2025 at 11:34 AM
📢Last weeks #immunometabolism discoveries
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Highlights:
I) Glucose-dependent glycosphingolipid biosynthesis fuels CD8+ T cell function and tumor control - cell.com/cell-metabol...
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Highlights:
I) Glucose-dependent glycosphingolipid biosynthesis fuels CD8+ T cell function and tumor control - cell.com/cell-metabol...
🔉Last week's #immunometabolism discoveries
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Highlights:
I) The RNA-binding protein RRP1 brakes macrophage one-carbon metabolism to suppress autoinflammation - nature.com/articles/s41...
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Highlights:
I) The RNA-binding protein RRP1 brakes macrophage one-carbon metabolism to suppress autoinflammation - nature.com/articles/s41...
August 7, 2025 at 9:10 AM
🔉Last week's #immunometabolism discoveries
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Highlights:
I) The RNA-binding protein RRP1 brakes macrophage one-carbon metabolism to suppress autoinflammation - nature.com/articles/s41...
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Highlights:
I) The RNA-binding protein RRP1 brakes macrophage one-carbon metabolism to suppress autoinflammation - nature.com/articles/s41...
🔊Last weeks #immunometabolism findings
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
A large & varied collection this week (1/n)
The essential host genome for Cryptosporidium survival exposes metabolic dependencies that can be leveraged for treatment
sciencedirect.com/science/arti...
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
A large & varied collection this week (1/n)
The essential host genome for Cryptosporidium survival exposes metabolic dependencies that can be leveraged for treatment
sciencedirect.com/science/arti...
July 28, 2025 at 10:19 AM
🔊Last weeks #immunometabolism findings
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
A large & varied collection this week (1/n)
The essential host genome for Cryptosporidium survival exposes metabolic dependencies that can be leveraged for treatment
sciencedirect.com/science/arti...
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
A large & varied collection this week (1/n)
The essential host genome for Cryptosporidium survival exposes metabolic dependencies that can be leveraged for treatment
sciencedirect.com/science/arti...
📢Last weeks #immunometabolism discoveries
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Highlights:
Controlling mitochondrial membrane architecture via MIC60 determines viral replication to promote anti-viral immunity (1/n)
cell.com/cell-reports...
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Highlights:
Controlling mitochondrial membrane architecture via MIC60 determines viral replication to promote anti-viral immunity (1/n)
cell.com/cell-reports...
July 17, 2025 at 9:48 AM
📢Last weeks #immunometabolism discoveries
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Highlights:
Controlling mitochondrial membrane architecture via MIC60 determines viral replication to promote anti-viral immunity (1/n)
cell.com/cell-reports...
@biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Highlights:
Controlling mitochondrial membrane architecture via MIC60 determines viral replication to promote anti-viral immunity (1/n)
cell.com/cell-reports...
Big thank you to @immunometlab.bsky.social
for the invitation to speak at ImmunoMetNet meeting
yesterday. It was a great day of #immunometabolism and it was fantastic that a former Master's intern of mine Robbin Kramer also gave a talk on her current PhD work!
for the invitation to speak at ImmunoMetNet meeting
yesterday. It was a great day of #immunometabolism and it was fantastic that a former Master's intern of mine Robbin Kramer also gave a talk on her current PhD work!
June 27, 2025 at 11:01 AM
Big thank you to @immunometlab.bsky.social
for the invitation to speak at ImmunoMetNet meeting
yesterday. It was a great day of #immunometabolism and it was fantastic that a former Master's intern of mine Robbin Kramer also gave a talk on her current PhD work!
for the invitation to speak at ImmunoMetNet meeting
yesterday. It was a great day of #immunometabolism and it was fantastic that a former Master's intern of mine Robbin Kramer also gave a talk on her current PhD work!
📢Last week's #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting reviews:
Immunometabolism in systemic lupus erythematosus
Iron and the immune system
Plus many interesting articles inside!
biomed.news/bims-imicid/...
Interesting reviews:
Immunometabolism in systemic lupus erythematosus
Iron and the immune system
Plus many interesting articles inside!
June 23, 2025 at 4:58 PM
📢Last week's #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️
biomed.news/bims-imicid/...
Interesting reviews:
Immunometabolism in systemic lupus erythematosus
Iron and the immune system
Plus many interesting articles inside!
biomed.news/bims-imicid/...
Interesting reviews:
Immunometabolism in systemic lupus erythematosus
Iron and the immune system
Plus many interesting articles inside!
Our labs Science meets Abstraction - M.C. Escher's Mitochondrion
June 15, 2025 at 10:32 PM
Our labs Science meets Abstraction - M.C. Escher's Mitochondrion
🚨Last week's #immunometabolism findings
@biomednews.bsky.social 🔽🔽🔽
biomed.news/bims-imicid/...
Interesting paper:
Glucose-1-phosphate promotes compartmentalization of glycogen with the pentose phosphate pathway in CD8+ memory T cells
@biomednews.bsky.social 🔽🔽🔽
biomed.news/bims-imicid/...
Interesting paper:
Glucose-1-phosphate promotes compartmentalization of glycogen with the pentose phosphate pathway in CD8+ memory T cells
June 15, 2025 at 1:25 AM
🚨Last week's #immunometabolism findings
@biomednews.bsky.social 🔽🔽🔽
biomed.news/bims-imicid/...
Interesting paper:
Glucose-1-phosphate promotes compartmentalization of glycogen with the pentose phosphate pathway in CD8+ memory T cells
@biomednews.bsky.social 🔽🔽🔽
biomed.news/bims-imicid/...
Interesting paper:
Glucose-1-phosphate promotes compartmentalization of glycogen with the pentose phosphate pathway in CD8+ memory T cells
🚨Last weeks #immunometabolism discoveries @biomednews.bsky.social 🔽🔽🔽
biomed.news/bims-imicid/...
Interesting preprint:
SIRT4 Controls Macrophage Function and Wound Healing through Control of Protein Itaconylation in Mice: pubmed.ncbi.nlm.nih.gov/40463174/
biomed.news/bims-imicid/...
Interesting preprint:
SIRT4 Controls Macrophage Function and Wound Healing through Control of Protein Itaconylation in Mice: pubmed.ncbi.nlm.nih.gov/40463174/
June 13, 2025 at 3:14 PM
🚨Last weeks #immunometabolism discoveries @biomednews.bsky.social 🔽🔽🔽
biomed.news/bims-imicid/...
Interesting preprint:
SIRT4 Controls Macrophage Function and Wound Healing through Control of Protein Itaconylation in Mice: pubmed.ncbi.nlm.nih.gov/40463174/
biomed.news/bims-imicid/...
Interesting preprint:
SIRT4 Controls Macrophage Function and Wound Healing through Control of Protein Itaconylation in Mice: pubmed.ncbi.nlm.nih.gov/40463174/
June 5, 2025 at 1:22 PM
This is a very elegant piece of work. While focused primarily on novel glutathione metabolic networks, the authors also confirmed our previous identification of Itaconate-cysteine in macrophages, but also identified a new metabolite Sulfoitaconate. Very cool!
nature.com/articles/s4146…
nature.com/articles/s4146…
June 1, 2025 at 3:34 PM
This is a very elegant piece of work. While focused primarily on novel glutathione metabolic networks, the authors also confirmed our previous identification of Itaconate-cysteine in macrophages, but also identified a new metabolite Sulfoitaconate. Very cool!
nature.com/articles/s4146…
nature.com/articles/s4146…