Jakob Ørtvig
@rtvig-j.bsky.social
Oxford Nanopore employee, work related posts, views are my own
Reposted by Jakob Ørtvig
New hifiasm-ONT assembly method delivers high-quality, cost-efficient near T2T assemblies using standard Oxford Nanopore Simplex reads, broadening access to comprehensive genome assemblies across research and clinical applications. https://bit.ly/4awzU15
February 5, 2026 at 5:12 PM
New hifiasm-ONT assembly method delivers high-quality, cost-efficient near T2T assemblies using standard Oxford Nanopore Simplex reads, broadening access to comprehensive genome assemblies across research and clinical applications. https://bit.ly/4awzU15
Reposted by Jakob Ørtvig
Join Marilyn Li, who will kick off the talks at #AGBT, sharing how the simultaneous detection of genetic and epigenetic landscapes in cancer is enabling deeper characterisation and uncovering insights that were previously out of reach. https://bit.ly/45sPARe
February 3, 2026 at 5:09 PM
Join Marilyn Li, who will kick off the talks at #AGBT, sharing how the simultaneous detection of genetic and epigenetic landscapes in cancer is enabling deeper characterisation and uncovering insights that were previously out of reach. https://bit.ly/45sPARe
Reposted by Jakob Ørtvig
Time for a thread on our Christmas preprint “Origin and evolution of acrocentric chromosomes in human and great apes”. I had so much fun with this project and paper. It will be hard to summarize in a thread, but I’ll try www.biorxiv.org/content/10.6... [1/21]
February 2, 2026 at 2:58 PM
Time for a thread on our Christmas preprint “Origin and evolution of acrocentric chromosomes in human and great apes”. I had so much fun with this project and paper. It will be hard to summarize in a thread, but I’ll try www.biorxiv.org/content/10.6... [1/21]
Reposted by Jakob Ørtvig
In case you missed it, the recording of the BugSeq + @nanoporetech.com webinar is now available on demand! Discover how Dr. Georgios Kitsios used BugSeq for respiratory metagenomics in the @upmc.com ICU:
nanoporetech.com/resource-cen...
nanoporetech.com/resource-cen...
January 28, 2026 at 6:39 PM
In case you missed it, the recording of the BugSeq + @nanoporetech.com webinar is now available on demand! Discover how Dr. Georgios Kitsios used BugSeq for respiratory metagenomics in the @upmc.com ICU:
nanoporetech.com/resource-cen...
nanoporetech.com/resource-cen...
Reposted by Jakob Ørtvig
Enter our image competition for a chance to win a free ticket to this year's London Calling!
Hurry, entry closes midnight, 28th February 2026.
Submit your entry here: https://bit.ly/3KtPGR7
Hurry, entry closes midnight, 28th February 2026.
Submit your entry here: https://bit.ly/3KtPGR7
December 9, 2025 at 4:15 PM
Enter our image competition for a chance to win a free ticket to this year's London Calling!
Hurry, entry closes midnight, 28th February 2026.
Submit your entry here: https://bit.ly/3KtPGR7
Hurry, entry closes midnight, 28th February 2026.
Submit your entry here: https://bit.ly/3KtPGR7
Reposted by Jakob Ørtvig
Microflora Danica: What can you learn from collecting and sequencing 10,000+ samples from a single country? Check out our new paper in @nature.com to find out. Incredible work led by Caitlin Singleton, Thomas B. N. Jensen, and Mads Albertsen from @aau.dk. 🦠🧫🧬
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The Microflora Danica atlas of Danish environmental microbiomes - Nature
Microflora Danica—an atlas of Danish environmental microbiomes—reveals that although human-disturbed habitats have high alpha diversity, species reoccur, revealing hidden homogeneity.
www.nature.com
December 3, 2025 at 8:50 PM
Microflora Danica: What can you learn from collecting and sequencing 10,000+ samples from a single country? Check out our new paper in @nature.com to find out. Incredible work led by Caitlin Singleton, Thomas B. N. Jensen, and Mads Albertsen from @aau.dk. 🦠🧫🧬
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Jakob Ørtvig
Our cornetto work is now published at www.nature.com/articles/s41...
It can do near-T2T assembly using @nanoporetech.com adaptive sampling
- with less 💸
- reference agnostic, so works for non-humans
- not just blood, even saliva
Just presented at #abacbs2025 yesterday.
It can do near-T2T assembly using @nanoporetech.com adaptive sampling
- with less 💸
- reference agnostic, so works for non-humans
- not just blood, even saliva
Just presented at #abacbs2025 yesterday.
Targeted sequencing and iterative assembly of near-complete genomes - Nature Communications
Long-read sequencing enables high-quality genome assemblies, but challenges remain. Here, the authors introduce Cornetto, a method that improves assembly quality, enables genome sequencing from saliva...
www.nature.com
November 26, 2025 at 4:12 AM
Our cornetto work is now published at www.nature.com/articles/s41...
It can do near-T2T assembly using @nanoporetech.com adaptive sampling
- with less 💸
- reference agnostic, so works for non-humans
- not just blood, even saliva
Just presented at #abacbs2025 yesterday.
It can do near-T2T assembly using @nanoporetech.com adaptive sampling
- with less 💸
- reference agnostic, so works for non-humans
- not just blood, even saliva
Just presented at #abacbs2025 yesterday.
Reposted by Jakob Ørtvig
Did not expect to see disk space become an issue but after a disk clean up and restart I ended up with 243 and 244 gbp for these two @nanoporetech.com flowcells 🎉🚀🧬 💚🟩💚🟩💚🟩
November 4, 2025 at 12:10 PM
Did not expect to see disk space become an issue but after a disk clean up and restart I ended up with 243 and 244 gbp for these two @nanoporetech.com flowcells 🎉🚀🧬 💚🟩💚🟩💚🟩
Reposted by Jakob Ørtvig
Our MARTi @nanoporetech.com paper is now out in @genomeresearch.bsky.social after several years of development (particularly Ned Peel and Sam Martin). We'd love to hear from users about how you're using it, or suggestions for new features. @earlhaminst.bsky.social
genome.cshlp.org/content/earl...
genome.cshlp.org/content/earl...
Real-time analysis and visualization of nanopore metagenomic samples with MARTi
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights into the biology of all organisms
genome.cshlp.org
October 28, 2025 at 9:36 AM
Our MARTi @nanoporetech.com paper is now out in @genomeresearch.bsky.social after several years of development (particularly Ned Peel and Sam Martin). We'd love to hear from users about how you're using it, or suggestions for new features. @earlhaminst.bsky.social
genome.cshlp.org/content/earl...
genome.cshlp.org/content/earl...
Reposted by Jakob Ørtvig
Trio-barcoded @nanoporetech.com Adaptive Sampling (TBAS) to improve #RareDisease diagnostic at less than 1/2 the $$ & high cov: 76% solve rate across 13 trios inc. two corrections from prev. diagnosis. www.medrxiv.org/content/10.1...
@gregor-research.bsky.social @bcmhgsc.bsky.social
#Research
@gregor-research.bsky.social @bcmhgsc.bsky.social
#Research
October 27, 2025 at 1:05 PM
Trio-barcoded @nanoporetech.com Adaptive Sampling (TBAS) to improve #RareDisease diagnostic at less than 1/2 the $$ & high cov: 76% solve rate across 13 trios inc. two corrections from prev. diagnosis. www.medrxiv.org/content/10.1...
@gregor-research.bsky.social @bcmhgsc.bsky.social
#Research
@gregor-research.bsky.social @bcmhgsc.bsky.social
#Research
Reposted by Jakob Ørtvig
Overall we found more than 300 previously unreported RNA isoforms from 31 genes in brain. Some were highly abundant or even the dominant isoform, and we could show translation of novel RNAs into novel proteoforms, including new isoforms of the depression risk gene ITIH4 (see image).
October 3, 2025 at 4:18 AM
Overall we found more than 300 previously unreported RNA isoforms from 31 genes in brain. Some were highly abundant or even the dominant isoform, and we could show translation of novel RNAs into novel proteoforms, including new isoforms of the depression risk gene ITIH4 (see image).
Reposted by Jakob Ørtvig
Methylation goes beyond just 5mC, but legacy sequencing methods do not.
Join our CoLab at #ASHG to learn how Dr Leyland Taylor is unravelling the dynamic regulatory role of multiple RNA mods in type 2 diabetes using Oxford Nanopore sequencing. nanoporetech.com/about/events...
Join our CoLab at #ASHG to learn how Dr Leyland Taylor is unravelling the dynamic regulatory role of multiple RNA mods in type 2 diabetes using Oxford Nanopore sequencing. nanoporetech.com/about/events...
October 1, 2025 at 4:25 PM
Methylation goes beyond just 5mC, but legacy sequencing methods do not.
Join our CoLab at #ASHG to learn how Dr Leyland Taylor is unravelling the dynamic regulatory role of multiple RNA mods in type 2 diabetes using Oxford Nanopore sequencing. nanoporetech.com/about/events...
Join our CoLab at #ASHG to learn how Dr Leyland Taylor is unravelling the dynamic regulatory role of multiple RNA mods in type 2 diabetes using Oxford Nanopore sequencing. nanoporetech.com/about/events...
Reposted by Jakob Ørtvig
PhD opportunity available on epigenomics/trasncriptomics as part of the network of clinicians and researchers working in glioblastoma research at @uniofnottingham.bsky.social Using a wide range of tech and methods but definitely long reads @nanoporetech.com - more at lnkd.in/eBtrtZiM
LinkedIn
This link will take you to a page that’s not on LinkedIn
lnkd.in
September 25, 2025 at 5:42 PM
PhD opportunity available on epigenomics/trasncriptomics as part of the network of clinicians and researchers working in glioblastoma research at @uniofnottingham.bsky.social Using a wide range of tech and methods but definitely long reads @nanoporetech.com - more at lnkd.in/eBtrtZiM
Reposted by Jakob Ørtvig
Epigenetic diagnosis of acute leukemia within two hours from sample receipt 🚀
Very happy to share the results of a great collaboration between @hovestadt.bsky.social and Griffin Labs, I co-led with @sbenfatto.bsky.social, published today in @natgenet.nature.com
📄 www.nature.com/articles/s41...
🧵1/n
Very happy to share the results of a great collaboration between @hovestadt.bsky.social and Griffin Labs, I co-led with @sbenfatto.bsky.social, published today in @natgenet.nature.com
📄 www.nature.com/articles/s41...
🧵1/n
Rapid epigenomic classification of acute leukemia - Nature Genetics
The authors present a molecular classification of acute leukemia using 5-methylcytosine signatures, together with a neural network-based classifier for clinical use.
www.nature.com
September 22, 2025 at 8:41 PM
Epigenetic diagnosis of acute leukemia within two hours from sample receipt 🚀
Very happy to share the results of a great collaboration between @hovestadt.bsky.social and Griffin Labs, I co-led with @sbenfatto.bsky.social, published today in @natgenet.nature.com
📄 www.nature.com/articles/s41...
🧵1/n
Very happy to share the results of a great collaboration between @hovestadt.bsky.social and Griffin Labs, I co-led with @sbenfatto.bsky.social, published today in @natgenet.nature.com
📄 www.nature.com/articles/s41...
🧵1/n
Reposted by Jakob Ørtvig
Introducing our new Microbial Amplicon Barcoding Kit, which enhances microbial community profiling with an information-rich, rapid & accessible protocol for streamlined identification of bacteria, archaea & fungi — in one go. nanoporetech.com/news/oxford-...
September 18, 2025 at 11:12 AM
Introducing our new Microbial Amplicon Barcoding Kit, which enhances microbial community profiling with an information-rich, rapid & accessible protocol for streamlined identification of bacteria, archaea & fungi — in one go. nanoporetech.com/news/oxford-...
Reposted by Jakob Ørtvig
A postdoc position in genomics available at our infrastructure in Uppsala, Sweden! An interesting R&D role a bit outside the traditional academic environment, great colleagues, work at the forefront of (long-read) sequencing.
www.uu.se/en/about-uu/...
www.uu.se/en/about-uu/...
Postdoctoral position - Uppsala University
Postdoctoral position, Department of Immunology, Genetics and Pathology, Uppsala University
www.uu.se
August 19, 2025 at 1:21 PM
A postdoc position in genomics available at our infrastructure in Uppsala, Sweden! An interesting R&D role a bit outside the traditional academic environment, great colleagues, work at the forefront of (long-read) sequencing.
www.uu.se/en/about-uu/...
www.uu.se/en/about-uu/...
Reposted by Jakob Ørtvig
What if targeted sequencing actually meant targeted?
Uncover how Oxford Nanopore’s adaptive sequencing delivers high coverage, faster results & a more efficient workflow than WGS — all in our latest Nanopore Know-How post.
Read here: nanoporetech.com/blog/adaptiv...
Uncover how Oxford Nanopore’s adaptive sequencing delivers high coverage, faster results & a more efficient workflow than WGS — all in our latest Nanopore Know-How post.
Read here: nanoporetech.com/blog/adaptiv...
August 14, 2025 at 11:04 AM
What if targeted sequencing actually meant targeted?
Uncover how Oxford Nanopore’s adaptive sequencing delivers high coverage, faster results & a more efficient workflow than WGS — all in our latest Nanopore Know-How post.
Read here: nanoporetech.com/blog/adaptiv...
Uncover how Oxford Nanopore’s adaptive sequencing delivers high coverage, faster results & a more efficient workflow than WGS — all in our latest Nanopore Know-How post.
Read here: nanoporetech.com/blog/adaptiv...
Reposted by Jakob Ørtvig
Very excited to see our latest paper published!
Our paper using Oxford #Nanopore direct RNA sequencing to identify m6A modifications on RNA isoforms in human brain is now out in Science Advances. 🧪
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Isoform-level profiling of m6A epitranscriptomic signatures in human brain
Direct RNA-seq in brain reveals RNA isoform and region-specific m6A modifications, highlighting their role in gene regulation.
www.science.org
August 12, 2025 at 9:52 AM
Very excited to see our latest paper published!
Reposted by Jakob Ørtvig
ELRIN completes two T2T human genomes — using only #Nanopore data.
As part of their mission to advance clinical diagnostics, ELRIN has released two complete, haplotype-phased genomes—enabling deeper insights into genetic variation that could inform future clinical research elrin-network.eu/t2t.html
As part of their mission to advance clinical diagnostics, ELRIN has released two complete, haplotype-phased genomes—enabling deeper insights into genetic variation that could inform future clinical research elrin-network.eu/t2t.html
June 26, 2025 at 4:08 PM
ELRIN completes two T2T human genomes — using only #Nanopore data.
As part of their mission to advance clinical diagnostics, ELRIN has released two complete, haplotype-phased genomes—enabling deeper insights into genetic variation that could inform future clinical research elrin-network.eu/t2t.html
As part of their mission to advance clinical diagnostics, ELRIN has released two complete, haplotype-phased genomes—enabling deeper insights into genetic variation that could inform future clinical research elrin-network.eu/t2t.html
Reposted by Jakob Ørtvig
Each year at @asm.org I'm blown away by the growing amount of presentations and posters leveraging @nanoporetech.com. This year we identified nearly 100 abstracts, ranging from clinical micro & public health applications to environmental research. See you there! nanoporetech.com/about/events...
June 16, 2025 at 6:53 PM
Each year at @asm.org I'm blown away by the growing amount of presentations and posters leveraging @nanoporetech.com. This year we identified nearly 100 abstracts, ranging from clinical micro & public health applications to environmental research. See you there! nanoporetech.com/about/events...
Reposted by Jakob Ørtvig
In this article, GenomeWeb explores Oxford Nanopore Technologies' collaboration with the ELRIN consortium and how they are researching the potential of Oxford Nanopore sequencing as a first-line diagnostic tool for #rarediseases and familial #cancers.
Read here: www.genomeweb.com/sequencing/e...
Read here: www.genomeweb.com/sequencing/e...
June 9, 2025 at 4:49 PM
In this article, GenomeWeb explores Oxford Nanopore Technologies' collaboration with the ELRIN consortium and how they are researching the potential of Oxford Nanopore sequencing as a first-line diagnostic tool for #rarediseases and familial #cancers.
Read here: www.genomeweb.com/sequencing/e...
Read here: www.genomeweb.com/sequencing/e...
Reposted by Jakob Ørtvig
Oxford Nanopore Tech Update LC2025. My full analysis of what this means for NGS and Multi-Omics, including the new Proteomics PoC. open.substack.com/pub/albertvi...
Oxford Nanopore Tech Update LC2025 highlights
My highlights from the LC2025 announcements
open.substack.com
May 27, 2025 at 6:45 AM
Oxford Nanopore Tech Update LC2025. My full analysis of what this means for NGS and Multi-Omics, including the new Proteomics PoC. open.substack.com/pub/albertvi...
Reposted by Jakob Ørtvig
Lennart Kester showcased their deep-learning tools, that combined with Oxford Nanopore sequencing, classify paediatric tumours in under two hours – potentially enabling same-day, cost-effective and intraoperative characterisation in the future. #NanoporeConf
May 22, 2025 at 2:15 PM
Lennart Kester showcased their deep-learning tools, that combined with Oxford Nanopore sequencing, classify paediatric tumours in under two hours – potentially enabling same-day, cost-effective and intraoperative characterisation in the future. #NanoporeConf
Reposted by Jakob Ørtvig
Very excited to present the Great Barrier Reef Microbial Genomes Database (GBR-MGD), a comprehensive DB of 1000s of high-quality prokaryote, virus, plasmid, and chromosome-level eukaryote MAGs using Nanopore long reads. Subthreads incoming. Please share widely. 🙂
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
The planktonic microbiome of the Great Barrier Reef
Large genome databases have markedly improved our understanding of marine microorganisms. Although these resources have focused on prokaryotes, genomes from many dominant marine lineages, such as Pela...
www.biorxiv.org
May 21, 2025 at 7:34 AM
Very excited to present the Great Barrier Reef Microbial Genomes Database (GBR-MGD), a comprehensive DB of 1000s of high-quality prokaryote, virus, plasmid, and chromosome-level eukaryote MAGs using Nanopore long reads. Subthreads incoming. Please share widely. 🙂
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Jakob Ørtvig
Really pleased that this paper is out - academic.oup.com/neuro-oncolo... thanks to all our collaborators far and wide who have helped and of course @nanoporetech.com
ROBIN: A unified nanopore-based assay integrating intraoperative methylome classification and next-day comprehensive profiling for ultra-rapid tumor diagnosis
academic.oup.com
May 21, 2025 at 9:26 AM
Really pleased that this paper is out - academic.oup.com/neuro-oncolo... thanks to all our collaborators far and wide who have helped and of course @nanoporetech.com