Reid Oshiro
@rtoshiro.bsky.social
PostDoc; Seed lab, UC Berkeley | PhD, Microbiology; Kearns lab, IU Biology | Love microbiology and baking! HI ➡️ IN ➡️ CA | he/him 🏳️🌈
Reposted by Reid Oshiro
First the link to the preprint: www.biorxiv.org/content/10.1...
Systematic mapping of bacteriophage gene essentiality with HIDEN‑SEQ
The constant arms race of bacteriophages and their bacterial hosts has inspired major breakthroughs in biotechnology and shaped phages as fierce predators with great clinical potential to fight multid...
www.biorxiv.org
November 20, 2025 at 6:52 PM
First the link to the preprint: www.biorxiv.org/content/10.1...
Reposted by Reid Oshiro
Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Intracellular competition shapes plasmid population dynamics
From populations of multicellular organisms to selfish genetic elements, conflicts between levels of biological organization are central to evolution. Plasmids are extrachromosomal, self-replicating g...
www.science.org
November 20, 2025 at 9:42 PM
Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Reid Oshiro
🚨Preprint alert - this is a big one! We transfer the revolutionary power of TnSeq to bacteriophages.
Our HIDEN-SEQ links the "dark matter" genes of your favorite phage to any selectable phenotype, guiding the path from fun observations to molecular mechanisms.
A thread 1/8
Our HIDEN-SEQ links the "dark matter" genes of your favorite phage to any selectable phenotype, guiding the path from fun observations to molecular mechanisms.
A thread 1/8
November 20, 2025 at 8:40 PM
🚨Preprint alert - this is a big one! We transfer the revolutionary power of TnSeq to bacteriophages.
Our HIDEN-SEQ links the "dark matter" genes of your favorite phage to any selectable phenotype, guiding the path from fun observations to molecular mechanisms.
A thread 1/8
Our HIDEN-SEQ links the "dark matter" genes of your favorite phage to any selectable phenotype, guiding the path from fun observations to molecular mechanisms.
A thread 1/8
I’m excited to share my recent postdoc work. Here, we interrogate how different phage infection outcomes (productive vs. restrictive) affect the expression of phage defense systems. We find that a restricted infection not only inhibits the phage but also induces increased immune protein abundance.
Surviving phage attack dynamically regulates bacterial immunity to defeat counterdefenses https://www.biorxiv.org/content/10.1101/2025.11.13.688357v1
November 15, 2025 at 6:10 PM
I’m excited to share my recent postdoc work. Here, we interrogate how different phage infection outcomes (productive vs. restrictive) affect the expression of phage defense systems. We find that a restricted infection not only inhibits the phage but also induces increased immune protein abundance.
Reposted by Reid Oshiro
Join the Blokesch lab (@EPFL) as a postdoc in Molecular Microbiology 🤩
Study Vibrio cholerae defense systems (phage/plasmid) in a dynamic, collaborative environment in Lausanne close to Lake Geneva in 🇨🇭!
Please visit my lab's webpage for details about the position and how to formally apply.
Study Vibrio cholerae defense systems (phage/plasmid) in a dynamic, collaborative environment in Lausanne close to Lake Geneva in 🇨🇭!
Please visit my lab's webpage for details about the position and how to formally apply.
April 25, 2025 at 4:15 PM
Join the Blokesch lab (@EPFL) as a postdoc in Molecular Microbiology 🤩
Study Vibrio cholerae defense systems (phage/plasmid) in a dynamic, collaborative environment in Lausanne close to Lake Geneva in 🇨🇭!
Please visit my lab's webpage for details about the position and how to formally apply.
Study Vibrio cholerae defense systems (phage/plasmid) in a dynamic, collaborative environment in Lausanne close to Lake Geneva in 🇨🇭!
Please visit my lab's webpage for details about the position and how to formally apply.
Reposted by Reid Oshiro
Adams Group webpage is live! #NIAIDNews #IRPatNIH #ResearchingSpirochetes 🔬🧫🧬
(Consider joining our team!!)
www.niaid.nih.gov/research/ada...
(Consider joining our team!!)
www.niaid.nih.gov/research/ada...
Adams Research Group
The Adams Research Group uses molecular and cellular techniques to manipulate spirochetes, sequence bacterial transcriptomes, characterize cellular processes, map regulatory networks, and study spiroc...
www.niaid.nih.gov
December 18, 2024 at 8:31 PM
Adams Group webpage is live! #NIAIDNews #IRPatNIH #ResearchingSpirochetes 🔬🧫🧬
(Consider joining our team!!)
www.niaid.nih.gov/research/ada...
(Consider joining our team!!)
www.niaid.nih.gov/research/ada...
Reposted by Reid Oshiro
Since we have had a big boom to bsky let me reintroduce myself.
I am Aisha Burton and a new PI at Cornell Micro. Currently on maternity leave but my two research techs are keeping the research going 🙏🏾. My lab is interested in studying small proteins and how they impact stress responses in bacteria
I am Aisha Burton and a new PI at Cornell Micro. Currently on maternity leave but my two research techs are keeping the research going 🙏🏾. My lab is interested in studying small proteins and how they impact stress responses in bacteria
November 12, 2024 at 10:38 PM
Since we have had a big boom to bsky let me reintroduce myself.
I am Aisha Burton and a new PI at Cornell Micro. Currently on maternity leave but my two research techs are keeping the research going 🙏🏾. My lab is interested in studying small proteins and how they impact stress responses in bacteria
I am Aisha Burton and a new PI at Cornell Micro. Currently on maternity leave but my two research techs are keeping the research going 🙏🏾. My lab is interested in studying small proteins and how they impact stress responses in bacteria
Really excited to share my first preprint as a postdoc! Here, we determined that the BREX-inhibitor, OrbA, encoded by the lytic phage ICP1 inhibits BREX through the ATPase BrxC in V. cholerae.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
The vibriophage-encoded inhibitor OrbA abrogates BREX-mediated defense through the ATPase BrxC
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
www.biorxiv.org
May 10, 2024 at 5:30 PM
Really excited to share my first preprint as a postdoc! Here, we determined that the BREX-inhibitor, OrbA, encoded by the lytic phage ICP1 inhibits BREX through the ATPase BrxC in V. cholerae.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Attention phage/microbiology 🧫🦠enthusiasts- the Seed lab kimseedlab.com @UCBerkeley is hiring a staff research associate, an ideal opportunity for folks looking to gain research experience before grad school/professional school careerspub.universityofcalifornia.edu/psp/ucb/EMPLOY… please share!
Seed Lab
Kim Seed is an Assistant Professor at the University of California,
Berkeley and her lab studies the interactions between bacteria and their
viral predators (bacteriophages), and how these interacti...
kimseedlab.com
November 9, 2023 at 6:21 PM
Attention phage/microbiology 🧫🦠enthusiasts- the Seed lab kimseedlab.com @UCBerkeley is hiring a staff research associate, an ideal opportunity for folks looking to gain research experience before grad school/professional school careerspub.universityofcalifornia.edu/psp/ucb/EMPLOY… please share!
Yay @aishaburton.bsky.social glad to see this out!
The alternative sigma factor SigN of Bacillus subtilis is intrinsically toxic
J Bacteriology by Aisha Burton et al from Dan Kearns lab
with Libor Krásný lab
journals.asm.org/doi/10.1128/...
J Bacteriology by Aisha Burton et al from Dan Kearns lab
with Libor Krásný lab
journals.asm.org/doi/10.1128/...
September 21, 2023 at 6:05 PM
Yay @aishaburton.bsky.social glad to see this out!