Ruslan Rust
@rrust.bsky.social
Asst Prof at @keckmedicineusc.bsky.social with interest in the #brain, #BBB, #stemcells and what can go wrong following #stroke & #AD. 🧠 🔬 Alumni of @ethzurich.bsky.social
Check out the preprint, we appreciate any feedback:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Molecular signature and functional properties of human pluripotent stem cell-derived brain pericytes
Brain pericytes maintain the blood-brain barrier (BBB), secrete neurotrophic factors and clear toxic proteins. Their loss in neurological disorders leads to BBB breakdown, neuronal dysfunction, and co...
www.biorxiv.org
April 10, 2025 at 11:09 PM
Check out the preprint, we appreciate any feedback:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Since mouse pericytes have been shown to clear Aβ and tau from the brain, we showed that our iPSC-pericytes are also capable of clearing Aβ and tau, and that this clearance is dependent on the lipoprotein receptor LRP1, a major Aβ clearance receptor.
April 10, 2025 at 11:09 PM
Since mouse pericytes have been shown to clear Aβ and tau from the brain, we showed that our iPSC-pericytes are also capable of clearing Aβ and tau, and that this clearance is dependent on the lipoprotein receptor LRP1, a major Aβ clearance receptor.
Functionally, iPSC-pericyte transplantation locally restored BBB integrity and promoted neuronal survival in the hippocampus of pericyte-deficient mice
April 10, 2025 at 11:09 PM
Functionally, iPSC-pericyte transplantation locally restored BBB integrity and promoted neuronal survival in the hippocampus of pericyte-deficient mice