RolfoLab
@rolfolab.bsky.social
Liquid Biopsy & Biomarkers Lab 🩸 🧬
🏫 The James Comprehensive Cancer Center - The Ohio State University
🏫 The James Comprehensive Cancer Center - The Ohio State University
5/5
Both TBx & LBx are suitable & complementary for METex14 skipping detection.
✅LBx Pros: Minimally invasive, rapid, feasible for ill patients/inaccessible tumors, boosts enrollment
❌ LBx Cons: Can have lower sensitivity (false negatives) with low ctDNA shedding
Both TBx & LBx are suitable & complementary for METex14 skipping detection.
✅LBx Pros: Minimally invasive, rapid, feasible for ill patients/inaccessible tumors, boosts enrollment
❌ LBx Cons: Can have lower sensitivity (false negatives) with low ctDNA shedding
May 5, 2025 at 1:58 PM
5/5
Both TBx & LBx are suitable & complementary for METex14 skipping detection.
✅LBx Pros: Minimally invasive, rapid, feasible for ill patients/inaccessible tumors, boosts enrollment
❌ LBx Cons: Can have lower sensitivity (false negatives) with low ctDNA shedding
Both TBx & LBx are suitable & complementary for METex14 skipping detection.
✅LBx Pros: Minimally invasive, rapid, feasible for ill patients/inaccessible tumors, boosts enrollment
❌ LBx Cons: Can have lower sensitivity (false negatives) with low ctDNA shedding
4/5
Further analysis: Among TBx-positive patients with matched LBx results, those who were LBx-negative showed trends for longer DOR, PFS, and OS compared to those who were also LBx-positive. (Fig3)
Further analysis: Among TBx-positive patients with matched LBx results, those who were LBx-negative showed trends for longer DOR, PFS, and OS compared to those who were also LBx-positive. (Fig3)
May 5, 2025 at 1:57 PM
4/5
Further analysis: Among TBx-positive patients with matched LBx results, those who were LBx-negative showed trends for longer DOR, PFS, and OS compared to those who were also LBx-positive. (Fig3)
Further analysis: Among TBx-positive patients with matched LBx results, those who were LBx-negative showed trends for longer DOR, PFS, and OS compared to those who were also LBx-positive. (Fig3)
3/5
Why the difference in time-dependent outcomes? LBx-positive patients had:
➡️ Higher baseline radiographic tumor burden
➡️ More extensive disease
➡️ Worse baseline health-related quality of life & symptoms.
Why the difference in time-dependent outcomes? LBx-positive patients had:
➡️ Higher baseline radiographic tumor burden
➡️ More extensive disease
➡️ Worse baseline health-related quality of life & symptoms.
May 5, 2025 at 1:55 PM
3/5
Why the difference in time-dependent outcomes? LBx-positive patients had:
➡️ Higher baseline radiographic tumor burden
➡️ More extensive disease
➡️ Worse baseline health-related quality of life & symptoms.
Why the difference in time-dependent outcomes? LBx-positive patients had:
➡️ Higher baseline radiographic tumor burden
➡️ More extensive disease
➡️ Worse baseline health-related quality of life & symptoms.
While ORRs were similar (TBx-pos 54.3% vs. LBx-pos 51.7%), time-dependent outcomes trended shorter in LBx-positive patients. 📉 mPFS: 13.7 mo (TBx) vs. 8.9 mo (LBx). 📉 Median OS: 22.9 mo (TBx) vs. 17.6 mo (LBx)
May 5, 2025 at 1:54 PM
While ORRs were similar (TBx-pos 54.3% vs. LBx-pos 51.7%), time-dependent outcomes trended shorter in LBx-positive patients. 📉 mPFS: 13.7 mo (TBx) vs. 8.9 mo (LBx). 📉 Median OS: 22.9 mo (TBx) vs. 17.6 mo (LBx)