Ryan O'Keefe
@rokeefemd.bsky.social
MD/MBA PennMedicine/Wharton | Hospitalist | Onc, Pall Care, MedEd | Creator Point of Care Medicine | Clinical threads and pearls
December 20, 2025 at 10:00 PM
December 19, 2025 at 10:00 PM
December 18, 2025 at 10:00 PM
December 17, 2025 at 10:00 PM
December 16, 2025 at 10:00 PM
December 15, 2025 at 10:00 PM
December 14, 2025 at 10:00 PM
December 13, 2025 at 10:00 PM
December 12, 2025 at 10:00 PM
December 11, 2025 at 10:00 PM
December 10, 2025 at 10:00 PM
December 9, 2025 at 10:00 PM
December 8, 2025 at 10:00 PM
Best of Clinical Cases from October 2025!
IM and Hospital Medicine Recap
Check out the most recent Substack post published this AM!
My favorite lessons and pearls from the best clinical cases from @CPSolvers @Dx_Atypia @runthelistpod @NEJM
Zero fluff, high-yield.
Link below!
IM and Hospital Medicine Recap
Check out the most recent Substack post published this AM!
My favorite lessons and pearls from the best clinical cases from @CPSolvers @Dx_Atypia @runthelistpod @NEJM
Zero fluff, high-yield.
Link below!
December 7, 2025 at 10:00 PM
Best of Clinical Cases from October 2025!
IM and Hospital Medicine Recap
Check out the most recent Substack post published this AM!
My favorite lessons and pearls from the best clinical cases from @CPSolvers @Dx_Atypia @runthelistpod @NEJM
Zero fluff, high-yield.
Link below!
IM and Hospital Medicine Recap
Check out the most recent Substack post published this AM!
My favorite lessons and pearls from the best clinical cases from @CPSolvers @Dx_Atypia @runthelistpod @NEJM
Zero fluff, high-yield.
Link below!
Chronic Coronary Artery Disease (Annals of Internal Medicine)
November 27, 2025 at 1:00 PM
Chronic Coronary Artery Disease (Annals of Internal Medicine)
Syphilis: A Review (JAMA)
November 26, 2025 at 10:00 PM
Syphilis: A Review (JAMA)
Lung-Cancer in Non-Smoking Individuals (JAMA)
November 25, 2025 at 10:00 PM
Lung-Cancer in Non-Smoking Individuals (JAMA)
Gluten vs fructans as a source of abdominal symptoms
Non-celiac gluten sensitivity Review (Lancet)
Non-celiac gluten sensitivity Review (Lancet)
November 24, 2025 at 10:00 PM
Gluten vs fructans as a source of abdominal symptoms
Non-celiac gluten sensitivity Review (Lancet)
Non-celiac gluten sensitivity Review (Lancet)
Evaluation Of Jaundice In Adults Review (AAFP)
November 23, 2025 at 10:00 PM
Evaluation Of Jaundice In Adults Review (AAFP)
New Substack post!
IM and Hospital Medicine Recap - Clinical Reviews (October, Part 2)
The best lessons and pearls from clinical reviews featuring Chronic CAD, syphilis, lung cancer in non-smokers, non-celiac gluten sensitivity, and evaluation of jaundice!
rokeefemd.substack.com/p/im-and-ho...
IM and Hospital Medicine Recap - Clinical Reviews (October, Part 2)
The best lessons and pearls from clinical reviews featuring Chronic CAD, syphilis, lung cancer in non-smokers, non-celiac gluten sensitivity, and evaluation of jaundice!
rokeefemd.substack.com/p/im-and-ho...
November 23, 2025 at 5:41 PM
New Substack post!
IM and Hospital Medicine Recap - Clinical Reviews (October, Part 2)
The best lessons and pearls from clinical reviews featuring Chronic CAD, syphilis, lung cancer in non-smokers, non-celiac gluten sensitivity, and evaluation of jaundice!
rokeefemd.substack.com/p/im-and-ho...
IM and Hospital Medicine Recap - Clinical Reviews (October, Part 2)
The best lessons and pearls from clinical reviews featuring Chronic CAD, syphilis, lung cancer in non-smokers, non-celiac gluten sensitivity, and evaluation of jaundice!
rokeefemd.substack.com/p/im-and-ho...
New Substack post!
IM + Hospital Medicine Recap
Clinical Reviews - October, Part 1
The top lessons and pearls from clinical reviews featuring MGUS, inpatient hyponatremia, dermatologic emergencies, tinea infections, and hair loss in women!
See the post and subscribe here:
rokeefemd.substack.com/
IM + Hospital Medicine Recap
Clinical Reviews - October, Part 1
The top lessons and pearls from clinical reviews featuring MGUS, inpatient hyponatremia, dermatologic emergencies, tinea infections, and hair loss in women!
See the post and subscribe here:
rokeefemd.substack.com/
November 17, 2025 at 1:30 AM
New Substack post!
IM + Hospital Medicine Recap
Clinical Reviews - October, Part 1
The top lessons and pearls from clinical reviews featuring MGUS, inpatient hyponatremia, dermatologic emergencies, tinea infections, and hair loss in women!
See the post and subscribe here:
rokeefemd.substack.com/
IM + Hospital Medicine Recap
Clinical Reviews - October, Part 1
The top lessons and pearls from clinical reviews featuring MGUS, inpatient hyponatremia, dermatologic emergencies, tinea infections, and hair loss in women!
See the post and subscribe here:
rokeefemd.substack.com/
Check out the @pointofcaremed page to learn more about ADHF and inpatient diuresis!
www.pointofcaremedicine.com/cardiology/...
www.pointofcaremedicine.com/blog-post/d...
www.pointofcaremedicine.com/cardiology/...
www.pointofcaremedicine.com/blog-post/d...
October 29, 2025 at 9:00 PM
Check out the @pointofcaremed page to learn more about ADHF and inpatient diuresis!
www.pointofcaremedicine.com/cardiology/...
www.pointofcaremedicine.com/blog-post/d...
www.pointofcaremedicine.com/cardiology/...
www.pointofcaremedicine.com/blog-post/d...
STEP-HFpEF trial demonstrated that Glucagon-like peptide-1 (GLP-1) receptor agonists significantly improve symptoms, physical function, and weight in patients with obesity-related HFpEF
October 29, 2025 at 9:00 PM
STEP-HFpEF trial demonstrated that Glucagon-like peptide-1 (GLP-1) receptor agonists significantly improve symptoms, physical function, and weight in patients with obesity-related HFpEF
Angiotensin Receptor-Neprilysin Inhibitors (ARNIs) - Entresto - also have a class 2b recommendation, having missed the primary endpoint in the PARAGON-HF trial, episode suggests it may be considered, particularly for patients with lower-range ejection fractions or persistent hypertension.
October 29, 2025 at 9:00 PM
Angiotensin Receptor-Neprilysin Inhibitors (ARNIs) - Entresto - also have a class 2b recommendation, having missed the primary endpoint in the PARAGON-HF trial, episode suggests it may be considered, particularly for patients with lower-range ejection fractions or persistent hypertension.
Mineralocorticoid Receptor Antagonists (MRAs) like spironolactone hold a class 2b recommendation; TOPCAT trial was neutral but subgroup analyses of patients from the Americas showed a benefit in reducing hospitalizations; the Jury is still out though
October 29, 2025 at 9:00 PM
Mineralocorticoid Receptor Antagonists (MRAs) like spironolactone hold a class 2b recommendation; TOPCAT trial was neutral but subgroup analyses of patients from the Americas showed a benefit in reducing hospitalizations; the Jury is still out though