Rob Clarke
@robclarkelab.bsky.social
Breast Biology Lab, UniManchester; researching stem cell signalling in development and cancer. Models inc. patient-derived organoids and xenografts.
Really happy to share a link to our work showing that anti-progestin therapy could help prevent breast cancer before menopause.
Published today in Nature, the study suggests this could be a new way to stop breast cancer before it starts: urldefense.com/v3/__https:/...
Brilliant team science
Published today in Nature, the study suggests this could be a new way to stop breast cancer before it starts: urldefense.com/v3/__https:/...
Brilliant team science
Anti-progestin therapy targets hallmarks of breast cancer risk
Nature - Results of an early-phase breast cancer prevention trial demonstrate the potential for breast cancer prevention in premenopausal women with anti-progestin therapy by inducing...
urldefense.com
November 5, 2025 at 9:07 PM
Really happy to share a link to our work showing that anti-progestin therapy could help prevent breast cancer before menopause.
Published today in Nature, the study suggests this could be a new way to stop breast cancer before it starts: urldefense.com/v3/__https:/...
Brilliant team science
Published today in Nature, the study suggests this could be a new way to stop breast cancer before it starts: urldefense.com/v3/__https:/...
Brilliant team science
Reposted by Rob Clarke
Thank you to everyone who joined us for the MBC Prevent Breast Cancer (PBC) Special Symposium & PBC Research Unit Launch today.
Special mention to all @preventbc.bsky.social, Andy Burnham Mayor of Greater Manchester,Geoff Lindeman & Jane Visvader from @wehi-research.bsky.social & all our researchers
Special mention to all @preventbc.bsky.social, Andy Burnham Mayor of Greater Manchester,Geoff Lindeman & Jane Visvader from @wehi-research.bsky.social & all our researchers
September 25, 2025 at 6:10 PM
Thank you to everyone who joined us for the MBC Prevent Breast Cancer (PBC) Special Symposium & PBC Research Unit Launch today.
Special mention to all @preventbc.bsky.social, Andy Burnham Mayor of Greater Manchester,Geoff Lindeman & Jane Visvader from @wehi-research.bsky.social & all our researchers
Special mention to all @preventbc.bsky.social, Andy Burnham Mayor of Greater Manchester,Geoff Lindeman & Jane Visvader from @wehi-research.bsky.social & all our researchers
Reposted by Rob Clarke
Starting September with an excellent seminar by Professor Roger Gomis from @irbbarcelona.org on “ER+ Breast cancer metastasis cell fate mapping”.
Thank you for visiting us in Manchester and sorry about the rain!
@mcrcnews.bsky.social @uom-dcs.bsky.social @cruk-mi.bsky.social
Thank you for visiting us in Manchester and sorry about the rain!
@mcrcnews.bsky.social @uom-dcs.bsky.social @cruk-mi.bsky.social
September 15, 2025 at 2:38 PM
Starting September with an excellent seminar by Professor Roger Gomis from @irbbarcelona.org on “ER+ Breast cancer metastasis cell fate mapping”.
Thank you for visiting us in Manchester and sorry about the rain!
@mcrcnews.bsky.social @uom-dcs.bsky.social @cruk-mi.bsky.social
Thank you for visiting us in Manchester and sorry about the rain!
@mcrcnews.bsky.social @uom-dcs.bsky.social @cruk-mi.bsky.social
An interesting story and great science from our current and former PhD students, Sara Cabral and Joe Parsons, in collaboration with Ciara O'Brien in Manchester and Chiara Francavilla in Denmark as well as colleagues in Sheffield, Hungary and the USA.
Proteomics Identifies Osteomodulin as a Promoter of Breast Cancer Bone Metastasis via CDK1 Activation
Metastasis to different organs remains the main cause of mortality in breast cancer. Molecular predictors of metastasis are limited as well as therapeutic options. Here, we conducted quantitative prot...
doi.org
August 6, 2025 at 1:13 PM
An interesting story and great science from our current and former PhD students, Sara Cabral and Joe Parsons, in collaboration with Ciara O'Brien in Manchester and Chiara Francavilla in Denmark as well as colleagues in Sheffield, Hungary and the USA.
Proud to present a nice story on ER+ breast cancer dormancy regulation from our former PhD student Ollie Cottrell, in collaboration with Nancy Papalopulu's group in Biological Sciences, University of Manchester
HES1 oscillations are required for cell cycle progression and re-entry in oestrogen receptor positive breast cancer cells
Long-term recurrence in breast cancer is driven by reactivation of dormant disseminated tumour cells (DTCs) and remains a major clinical challenge, particularly in oestrogen receptor positive (ER⁺) tu...
doi.org
August 6, 2025 at 1:08 PM
Proud to present a nice story on ER+ breast cancer dormancy regulation from our former PhD student Ollie Cottrell, in collaboration with Nancy Papalopulu's group in Biological Sciences, University of Manchester
Reposted by Rob Clarke
Thanks to Naga Munchetty for inviting Prof @robclarkelab.bsky.social from Manchester Breast Centre, Tristan Loraine from Lobular Moon Shot Project, patients & other guests to speak about lobular breast cancer on BBC Radio 5 Live today
BBC Sounds 🔗 starts at 12:04pm www.bbc.co.uk/sounds/play/...
BBC Sounds 🔗 starts at 12:04pm www.bbc.co.uk/sounds/play/...
Naga Munchetty - 22/07/2025 - BBC Sounds
Naga Munchetty features news, experiences, and big name interviews from around the UK.
www.bbc.co.uk
July 22, 2025 at 3:34 PM
Thanks to Naga Munchetty for inviting Prof @robclarkelab.bsky.social from Manchester Breast Centre, Tristan Loraine from Lobular Moon Shot Project, patients & other guests to speak about lobular breast cancer on BBC Radio 5 Live today
BBC Sounds 🔗 starts at 12:04pm www.bbc.co.uk/sounds/play/...
BBC Sounds 🔗 starts at 12:04pm www.bbc.co.uk/sounds/play/...
Reposted by Rob Clarke
Congratulations to Erin Durston-Hillyer and Finlay Spencer, newly graduated with Integrated Masters Degrees in Medical Biochemistry and Pharmacology, respectively, having successfully completed their research projects in the MBC Breast Biology group, supervised by Prof @robclarkelab.bsky.social
July 15, 2025 at 4:51 PM
Congratulations to Erin Durston-Hillyer and Finlay Spencer, newly graduated with Integrated Masters Degrees in Medical Biochemistry and Pharmacology, respectively, having successfully completed their research projects in the MBC Breast Biology group, supervised by Prof @robclarkelab.bsky.social
Reposted by Rob Clarke
Lobular Moon Shot Project campaigners will visit Downing Street tomorrow 24/6 to call for research into lobular breast cancer.
Prof @robclarkelab.bsky.social explains why this research is needed to provide specific treatments for patients👇
www.express.co.uk/news/uk/2072...
Prof @robclarkelab.bsky.social explains why this research is needed to provide specific treatments for patients👇
www.express.co.uk/news/uk/2072...
'I have a type of breast cancer most people have never heard of'
EXCLUSIVE: Campaigners will visit Downing Street on Tuesday to call for research into a specific type of breast cancer.
www.express.co.uk
June 23, 2025 at 5:05 PM
Lobular Moon Shot Project campaigners will visit Downing Street tomorrow 24/6 to call for research into lobular breast cancer.
Prof @robclarkelab.bsky.social explains why this research is needed to provide specific treatments for patients👇
www.express.co.uk/news/uk/2072...
Prof @robclarkelab.bsky.social explains why this research is needed to provide specific treatments for patients👇
www.express.co.uk/news/uk/2072...
Very happy to come down to Baylor Breast Center to give a seminar hosted by the legendary Jeff Rosen. It was great to catch up with my long time colleagues Kent OsborneRachel Schiff and Xiang Zhang. It’s not often I’m down here in Texas but they’re fantastic colleagues.
June 14, 2025 at 2:40 AM
Very happy to come down to Baylor Breast Center to give a seminar hosted by the legendary Jeff Rosen. It was great to catch up with my long time colleagues Kent OsborneRachel Schiff and Xiang Zhang. It’s not often I’m down here in Texas but they’re fantastic colleagues.
Reposted by Rob Clarke
Great to see some of our PhD researchers presenting their cutting-edge breast cancer research at the Manchester Cancer Research Centre - Division of Cancer Sciences Postgraduate Research Showcase this week.
@mcrcnews.bsky.social
@uom-dcs.bsky.social
@saracabral24.bsky.social
@mcrcnews.bsky.social
@uom-dcs.bsky.social
@saracabral24.bsky.social
June 3, 2025 at 9:31 AM
Great to see some of our PhD researchers presenting their cutting-edge breast cancer research at the Manchester Cancer Research Centre - Division of Cancer Sciences Postgraduate Research Showcase this week.
@mcrcnews.bsky.social
@uom-dcs.bsky.social
@saracabral24.bsky.social
@mcrcnews.bsky.social
@uom-dcs.bsky.social
@saracabral24.bsky.social
Reposted by Rob Clarke
The Breast Cancer Risk Assessment in Young Women (Bcan-Ray) project in memory of Sarah Harding identifies which younger women are at increased risk of the disease and could lead to women in their thirties being offered breast cancer checks on the NHS.
www.theguardian.com/science/2025...
www.theguardian.com/science/2025...
NHS could start offering breast cancer checks to women in their thirties
Currently women are only eligible for breast screening from the age of 50, but thousands are diagnosed younger
www.theguardian.com
May 30, 2025 at 9:25 PM
The Breast Cancer Risk Assessment in Young Women (Bcan-Ray) project in memory of Sarah Harding identifies which younger women are at increased risk of the disease and could lead to women in their thirties being offered breast cancer checks on the NHS.
www.theguardian.com/science/2025...
www.theguardian.com/science/2025...
Reposted by Rob Clarke
A massive thank you to @proteintech.bsky.social for the generous lunch they treated me and my lovely lab group @robclarkelab.bsky.social to after I won their recent lucky draw! 🎉
It was a thoughtful gesture that made our week, now back to the science 🧪 🧫
It was a thoughtful gesture that made our week, now back to the science 🧪 🧫
May 28, 2025 at 3:04 PM
A massive thank you to @proteintech.bsky.social for the generous lunch they treated me and my lovely lab group @robclarkelab.bsky.social to after I won their recent lucky draw! 🎉
It was a thoughtful gesture that made our week, now back to the science 🧪 🧫
It was a thoughtful gesture that made our week, now back to the science 🧪 🧫
Reposted by Rob Clarke
Drop-in event at Westminster today for MPs to find out more about the Lobular Moon Shot Project's call to provide £20million of research funding for research into lobular breast cancer @mcr-breastcentre.bsky.social
@robclarkelab.bsky.social @mcrcnews.bsky.social
@robclarkelab.bsky.social @mcrcnews.bsky.social
May 6, 2025 at 10:50 AM
Drop-in event at Westminster today for MPs to find out more about the Lobular Moon Shot Project's call to provide £20million of research funding for research into lobular breast cancer @mcr-breastcentre.bsky.social
@robclarkelab.bsky.social @mcrcnews.bsky.social
@robclarkelab.bsky.social @mcrcnews.bsky.social
Reposted by Rob Clarke
Our last work on triple negative breast cancer stem cells now in BiorXiv!! Let's hope for a smooth reviewing process!! @m-saponaro.bsky.social @breastcancernow.bsky.social @davieslab-ch3.bsky.social @robclarkelab.bsky.social 😃
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
MYBL2 maintains stemness and promotes theta-mediated end joining in triple negative breast cancer
Triple negative breast cancer (TNBC) has a poor prognosis due to limited treatment options and high metastasis risk. Breast cancer (BC) stem/progenitor cells, also known as tumour initiating cells, ar...
www.biorxiv.org
April 19, 2025 at 8:11 AM
Our last work on triple negative breast cancer stem cells now in BiorXiv!! Let's hope for a smooth reviewing process!! @m-saponaro.bsky.social @breastcancernow.bsky.social @davieslab-ch3.bsky.social @robclarkelab.bsky.social 😃
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Rob Clarke
Therese and @robclarkelab.bsky.social presenting the book they edited on “ A guide to breast cancer research “
April 25, 2025 at 7:49 AM
Therese and @robclarkelab.bsky.social presenting the book they edited on “ A guide to breast cancer research “
Jean Abraham and Jay Carroll are hosting me and others for #CPBC2025. Looking forward to hearing some exciting cancer science including Sir Steve Jackson and about the patient experience.
March 28, 2025 at 9:23 AM
Jean Abraham and Jay Carroll are hosting me and others for #CPBC2025. Looking forward to hearing some exciting cancer science including Sir Steve Jackson and about the patient experience.
This week a book project that Therese Sorlie and I have worked on for 18 months comes out. It is a collection of 24 chapters by world experts covering breast development, cancer, sub-types, metastasis, immunology and therapy. A Guide to Breast Cancer Research:
link.springer.com/book/10.1007...
link.springer.com/book/10.1007...
link.springer.com
January 21, 2025 at 2:50 PM
This week a book project that Therese Sorlie and I have worked on for 18 months comes out. It is a collection of 24 chapters by world experts covering breast development, cancer, sub-types, metastasis, immunology and therapy. A Guide to Breast Cancer Research:
link.springer.com/book/10.1007...
link.springer.com/book/10.1007...
Looking for suitable candidates to apply for a newly funded BBSRC 4 year PhD project to study the role
of stiffness and the extra cellular matrix in regulating normal human breast proliferation in response to hormone signals. Closing date: 31st January
www.findaphd.com/phds/project...
of stiffness and the extra cellular matrix in regulating normal human breast proliferation in response to hormone signals. Closing date: 31st January
www.findaphd.com/phds/project...
(BBSRC NWD) Uncovering the roles of collagen VI in normal breast tissue stiffness, signalling and proliferation at The University of Manchester on FindAPhD.com
PhD Project - (BBSRC NWD) Uncovering the roles of collagen VI in normal breast tissue stiffness, signalling and proliferation at The University of Manchester, listed on FindAPhD.com
www.findaphd.com
December 16, 2024 at 7:44 PM
Looking for suitable candidates to apply for a newly funded BBSRC 4 year PhD project to study the role
of stiffness and the extra cellular matrix in regulating normal human breast proliferation in response to hormone signals. Closing date: 31st January
www.findaphd.com/phds/project...
of stiffness and the extra cellular matrix in regulating normal human breast proliferation in response to hormone signals. Closing date: 31st January
www.findaphd.com/phds/project...
The European Network for Breast Development and Cancer 7th Annual Think Tank in Prague was fantastic as always. Great discussions, new collaborative possibilities and plenty of pre-Christmas festivities.
December 13, 2024 at 11:25 AM
The European Network for Breast Development and Cancer 7th Annual Think Tank in Prague was fantastic as always. Great discussions, new collaborative possibilities and plenty of pre-Christmas festivities.
Congratulations to BB lab’s own Dr Mia Nuckhir on successfully defending her PhD thesis ‘Soluble factors in the lung microenvironment promote pro-metastatic behaviours of breast cancer’ 🎉
Thanks to examiners Angeliki Malliri & Erik Saha & Mia's supervisors Ciara O'Brien & Hannah Harrison
Thanks to examiners Angeliki Malliri & Erik Saha & Mia's supervisors Ciara O'Brien & Hannah Harrison
December 11, 2024 at 8:44 AM
Congratulations to BB lab’s own Dr Mia Nuckhir on successfully defending her PhD thesis ‘Soluble factors in the lung microenvironment promote pro-metastatic behaviours of breast cancer’ 🎉
Thanks to examiners Angeliki Malliri & Erik Saha & Mia's supervisors Ciara O'Brien & Hannah Harrison
Thanks to examiners Angeliki Malliri & Erik Saha & Mia's supervisors Ciara O'Brien & Hannah Harrison