Robert Califf
@robcaliff.bsky.social
Happy Thanksgiving!
A message on all we still have to be grateful for
open.substack.com
November 28, 2025 at 1:58 AM
Opinion | We Can’t Diet and Exercise Our Way Out of the Next Pandemic
www.nytimes.com
November 27, 2025 at 4:43 PM
This nails it in my opinion. The big deal in AI is being explicit about the values that matter. Hinton is not talking about Google, despite the header--he's talking about where we are with AI and what we'd better pay attention to.
www.youtube.com/watch?v=yOC1...
www.youtube.com/watch?v=yOC1...
Google's new AI project is UNREAL | Geoffrey hinton
YouTube video by The AI Audiobook
www.youtube.com
November 27, 2025 at 2:33 PM
This nails it in my opinion. The big deal in AI is being explicit about the values that matter. Hinton is not talking about Google, despite the header--he's talking about where we are with AI and what we'd better pay attention to.
www.youtube.com/watch?v=yOC1...
www.youtube.com/watch?v=yOC1...
For people seeking information on hormone therapy I highly recommend this back and forth between 2 experts at translating information into knowledge.
vajenda.substack.com/p/jennifer-g...
vajenda.substack.com/p/jennifer-g...
Jennifer Gunter & Eric Topol - Discuss Women’s Health
From Dr. Jen Gunter and Eric Topol's live video
vajenda.substack.com
November 26, 2025 at 1:46 PM
For people seeking information on hormone therapy I highly recommend this back and forth between 2 experts at translating information into knowledge.
vajenda.substack.com/p/jennifer-g...
vajenda.substack.com/p/jennifer-g...
Sweezy v. New Hampshire (1957)
Academic Freedom & Cyclical Radicalism
open.substack.com
November 25, 2025 at 8:21 PM
Another good one from Lisa Rosenbaum. You get what you pay for? I am hearing more people in different sectors articulate the serious nature of our US primary care inadequacy.
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
Why Have We Chosen Not to Fix Primary Care? The Vicious Cycle of Medical Hierarchy | NEJM
Luring trainees to primary care requires making its work more tenable and increasing
its financial resources. But this recognition won’t lead to change without a transformation
of underlying values.
www.nejm.org
November 21, 2025 at 6:07 PM
Another good one from Lisa Rosenbaum. You get what you pay for? I am hearing more people in different sectors articulate the serious nature of our US primary care inadequacy.
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
This Isn’t Checkmate
Reflections from the morning after RFK’s CDC changed its vaccine-autism webpage
open.substack.com
November 20, 2025 at 10:08 PM
Tragic. Critical to promote reliable information from the biomedicine community.
CDC has overhauled its website to assert that “the claim ‘vaccines do not cause autism’ is not an evidence-based claim”
November 20, 2025 at 2:04 PM
Tragic. Critical to promote reliable information from the biomedicine community.
This is not surprising, but disappointing nonetheless. if wthe triple-demic takes off this winter (flu, covid, RSV) there will be excessive an unnecessary death, disability and hospital dysfunction due to the low vax rates and increase in insurance rates.
www.pewresearch.org/short-reads/...
www.pewresearch.org/short-reads/...
Have changes to CDC guidelines influenced Americans’ COVID-19 vaccine decisions?
A majority of U.S. adults (59%) say they don’t want to get an updated COVID-19 vaccine.
www.pewresearch.org
November 19, 2025 at 7:48 PM
This is not surprising, but disappointing nonetheless. if wthe triple-demic takes off this winter (flu, covid, RSV) there will be excessive an unnecessary death, disability and hospital dysfunction due to the low vax rates and increase in insurance rates.
www.pewresearch.org/short-reads/...
www.pewresearch.org/short-reads/...
Reposted by Robert Califf
My new post on Substack: Why patient-facing healthcare AI is a good idea, but general-purpose chatbots like GPT are probably not the right tool for the job. robertwachter.substack.com/p/we-need-me...
We Need Medical AI for Patients
But ChatGPT Isn't It
robertwachter.substack.com
November 18, 2025 at 9:59 PM
My new post on Substack: Why patient-facing healthcare AI is a good idea, but general-purpose chatbots like GPT are probably not the right tool for the job. robertwachter.substack.com/p/we-need-me...
Looks bad. More analysis need to sort out the impact and how to salvage needed answers to research questions.
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Clinical Trials Affected by Research Grant Terminations at the National Institutes of Health
This cross-sectional study summarizes the number of trials with terminated grants from the National Institutes of Health (NIH) and calculates the proportion of affected trials among those with previou...
jamanetwork.com
November 18, 2025 at 2:06 AM
Looks bad. More analysis need to sort out the impact and how to salvage needed answers to research questions.
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Good description of an important transition that is likely to make a big difference in outcomes.
open.substack.com/pub/erictopo...
open.substack.com/pub/erictopo...
The Big Shift in Cardiology to Atheroma and Inflammation
One A.I. company's tag line: "Creating A World Without Heart Attacks"
open.substack.com
November 17, 2025 at 1:53 AM
Good description of an important transition that is likely to make a big difference in outcomes.
open.substack.com/pub/erictopo...
open.substack.com/pub/erictopo...
This is a good summary--quite sad that so many well motivated and highly intelligent people work in a medical care system that has gotten so dysfunctional.
open.substack.com/pub/yourloca...
open.substack.com/pub/yourloca...
5 ways our health care system has become utterly insane
A deep dive into the U.S. health care system: rising costs, corporate takeover, and why reform keeps failing.
open.substack.com
November 12, 2025 at 11:06 PM
This is a good summary--quite sad that so many well motivated and highly intelligent people work in a medical care system that has gotten so dysfunctional.
open.substack.com/pub/yourloca...
open.substack.com/pub/yourloca...
Good summary from an expert. I hope Dr Mayne will produce a lot more substacks--she has a lot to contribute.
substack.com/home/post/p-...
substack.com/home/post/p-...
ByHeart, Botulism, and Powdered Infant Formula Safety
In the face of numerous questions about the ByHeart infant formula botulism outbreak, I wanted to share my perspective based on my prior experiences involving infant formula outbreaks and safety.
substack.com
November 12, 2025 at 3:42 AM
Good summary from an expert. I hope Dr Mayne will produce a lot more substacks--she has a lot to contribute.
substack.com/home/post/p-...
substack.com/home/post/p-...
Clinical research, particularly clinical trials, are not delivering enough evidence to inform us about what to emphasize and what to reduce as we spend $5 trillion per year on medical care and fail to address well known disparities and social drivers.
substack.com/@robcaliff27...
substack.com/@robcaliff27...
Why Don’t We Fix Informed Consent?
This essay, the first of a three-part series on informed consent, marks the second installment of a collection of posts devoted to specific issues in clinical research, with a focus on interventional ...
substack.com
November 11, 2025 at 3:48 PM
Clinical research, particularly clinical trials, are not delivering enough evidence to inform us about what to emphasize and what to reduce as we spend $5 trillion per year on medical care and fail to address well known disparities and social drivers.
substack.com/@robcaliff27...
substack.com/@robcaliff27...
Another useful update from YLE. Includes a poll on future update on deep dive on menopause.
open.substack.com/pub/yourloca...
open.substack.com/pub/yourloca...
Infant formula botulism cluster, black box warning for HRT, flu is waking up, new blood pressure guidelines, and more
This is your weekly Dose.
open.substack.com
November 10, 2025 at 2:29 PM
Another useful update from YLE. Includes a poll on future update on deep dive on menopause.
open.substack.com/pub/yourloca...
open.substack.com/pub/yourloca...
