Robin Hofmeister
@rjhfmstr.bsky.social
Postdoc with Z.Kutalik | research fellow with Lili Milani | Statistical modelling of haplotypes - parent of origin | skier, climber, windsurfer
Pinned
🚨 Our parent-of-origin study is out in Nature! 🧬
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗 www.nature.com/articles/s41...
Highlights below!
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗 www.nature.com/articles/s41...
Highlights below!
Reposted by Robin Hofmeister
Hi #ASHG2025, the Lausanne team made it to Boston ! Excited to present our latest discoveries — come say hi and learn more about our research! @samuelmoix.bsky.social @rjhfmstr.bsky.social
October 14, 2025 at 11:18 AM
Hi #ASHG2025, the Lausanne team made it to Boston ! Excited to present our latest discoveries — come say hi and learn more about our research! @samuelmoix.bsky.social @rjhfmstr.bsky.social
Reposted by Robin Hofmeister
I'm excited to share our pre-print about a new variant benchmarking tool we've been working on for the past few months!
Aardvark: Sifting through differences in a mound of variants
GitHub: github.com/PacificBiosc...
Some highlights in this thread:
1/N
Aardvark: Sifting through differences in a mound of variants
GitHub: github.com/PacificBiosc...
Some highlights in this thread:
1/N
October 6, 2025 at 8:07 PM
I'm excited to share our pre-print about a new variant benchmarking tool we've been working on for the past few months!
Aardvark: Sifting through differences in a mound of variants
GitHub: github.com/PacificBiosc...
Some highlights in this thread:
1/N
Aardvark: Sifting through differences in a mound of variants
GitHub: github.com/PacificBiosc...
Some highlights in this thread:
1/N
🚨 New preprint out!
We reconstructed parental haplotypes in >440k individuals (UK & Estonian biobanks) to estimate assortative mating directly in the parental generation.
This reveals intensified assortment in recent generations.
www.biorxiv.org/content/10.1...
We reconstructed parental haplotypes in >440k individuals (UK & Estonian biobanks) to estimate assortative mating directly in the parental generation.
This reveals intensified assortment in recent generations.
www.biorxiv.org/content/10.1...
September 26, 2025 at 5:10 PM
🚨 New preprint out!
We reconstructed parental haplotypes in >440k individuals (UK & Estonian biobanks) to estimate assortative mating directly in the parental generation.
This reveals intensified assortment in recent generations.
www.biorxiv.org/content/10.1...
We reconstructed parental haplotypes in >440k individuals (UK & Estonian biobanks) to estimate assortative mating directly in the parental generation.
This reveals intensified assortment in recent generations.
www.biorxiv.org/content/10.1...
Reposted by Robin Hofmeister
Traits like disease risk can be affected differently, and in opposite ways, depending on which parent the genetic variant responsible comes from. Work led by SIB scientists @zkutalik.bsky.social & Robin Hofmeister at @unil.bsky.social/UniSanté & published in Nature👇
www.sib.swiss/news/the-imp...
www.sib.swiss/news/the-imp...
The impact of genetic variants can depend on the parent they come from
Traits such as height, metabolism, and disease risk can be affected differently – and even in opposite directions – depending on whether the genetic variant responsible is inherited from the mothe...
www.sib.swiss
August 6, 2025 at 3:10 PM
Traits like disease risk can be affected differently, and in opposite ways, depending on which parent the genetic variant responsible comes from. Work led by SIB scientists @zkutalik.bsky.social & Robin Hofmeister at @unil.bsky.social/UniSanté & published in Nature👇
www.sib.swiss/news/the-imp...
www.sib.swiss/news/the-imp...
Reposted by Robin Hofmeister
Congratulations to Zoltan @zkutalik.bsky.social , Robin @rjhfmstr.bsky.social and the whole team for this fantastic work out today in @nature.com 👍 www.nature.com/articles/s41... Your parents' genome matters more than you think 😉https://www.unil.ch/dbc/en/home.html @fbm-unil.bsky.social
Parent-of-origin effects on complex traits in up to 236,781 individuals - Nature
A novel multistep strategy reveals how parent-of-origin effects shape complex traits in large-scale biobanks.
www.nature.com
August 7, 2025 at 10:23 AM
Congratulations to Zoltan @zkutalik.bsky.social , Robin @rjhfmstr.bsky.social and the whole team for this fantastic work out today in @nature.com 👍 www.nature.com/articles/s41... Your parents' genome matters more than you think 😉https://www.unil.ch/dbc/en/home.html @fbm-unil.bsky.social
Reposted by Robin Hofmeister
Study of 230,000 people finds many examples where the effect of a genetic variant differs depending on the parent of origin, especially for growth and metabolism - fascinating!
Amazing study, congrats @rjhfmstr.bsky.social, @zkutalik.bsky.social and team 👏
Amazing study, congrats @rjhfmstr.bsky.social, @zkutalik.bsky.social and team 👏
🚨 Our parent-of-origin study is out in Nature! 🧬
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗 www.nature.com/articles/s41...
Highlights below!
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗 www.nature.com/articles/s41...
Highlights below!
August 22, 2025 at 11:01 AM
Study of 230,000 people finds many examples where the effect of a genetic variant differs depending on the parent of origin, especially for growth and metabolism - fascinating!
Amazing study, congrats @rjhfmstr.bsky.social, @zkutalik.bsky.social and team 👏
Amazing study, congrats @rjhfmstr.bsky.social, @zkutalik.bsky.social and team 👏
Reposted by Robin Hofmeister
Extremely cool paper from @rjhfmstr.bsky.social @zkutalik.bsky.social and team. I still need to get my head around how the same genetic variant has opposite effects depending if it’s maternally or paternally inherited and why.
🚨 Our parent-of-origin study is out in Nature! 🧬
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗 www.nature.com/articles/s41...
Highlights below!
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗 www.nature.com/articles/s41...
Highlights below!
August 22, 2025 at 5:26 PM
Extremely cool paper from @rjhfmstr.bsky.social @zkutalik.bsky.social and team. I still need to get my head around how the same genetic variant has opposite effects depending if it’s maternally or paternally inherited and why.
Reposted by Robin Hofmeister
Reposted by Robin Hofmeister
Dirigée par @zkutalik.bsky.social et @rjhfmstr.bsky.social à la @fbm-unil.bsky.social, au @sib.swiss et à #unisanté, une nouvelle étude publiée dans @nature.com présente une méthode computationnelle innovante pour étudier ces effets liés à l’origine parentale.
🔗 www.nature.com/articles/s41...
🔗 www.nature.com/articles/s41...
Parent-of-origin effects on complex traits in up to 236,781 individuals - Nature
A novel multistep strategy reveals how parent-of-origin effects shape complex traits in large-scale biobanks.
www.nature.com
August 7, 2025 at 9:42 AM
Dirigée par @zkutalik.bsky.social et @rjhfmstr.bsky.social à la @fbm-unil.bsky.social, au @sib.swiss et à #unisanté, une nouvelle étude publiée dans @nature.com présente une méthode computationnelle innovante pour étudier ces effets liés à l’origine parentale.
🔗 www.nature.com/articles/s41...
🔗 www.nature.com/articles/s41...
🚨 Our parent-of-origin study is out in Nature! 🧬
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗 www.nature.com/articles/s41...
Highlights below!
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗 www.nature.com/articles/s41...
Highlights below!
August 6, 2025 at 6:27 PM
🚨 Our parent-of-origin study is out in Nature! 🧬
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗 www.nature.com/articles/s41...
Highlights below!
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗 www.nature.com/articles/s41...
Highlights below!
Thrilled to receive the Early Career Award for my presentation at #ESHG2025! 🧬
Big thanks to all the amazing collaborators on this project — couldn't have done it without you.
Grateful to the organizers and inspired by the science shared this week!
Big thanks to all the amazing collaborators on this project — couldn't have done it without you.
Grateful to the organizers and inspired by the science shared this week!
Extremely proud of @rjhfmstr.bsky.social for his @eshg.bsky.social Early Career Award received yesterday in Milan. A truly deserved recognition of his outstanding presentation and ingenious research on parent-of-origin effect inference! #ESHG2025
May 28, 2025 at 11:19 AM
Thrilled to receive the Early Career Award for my presentation at #ESHG2025! 🧬
Big thanks to all the amazing collaborators on this project — couldn't have done it without you.
Grateful to the organizers and inspired by the science shared this week!
Big thanks to all the amazing collaborators on this project — couldn't have done it without you.
Grateful to the organizers and inspired by the science shared this week!
Reposted by Robin Hofmeister
Particularly interesting talk from @rjhfmstr.bsky.social @ #ESHG25. Impressive work coming out of @unil.bsky.social 🧬🚀
May 26, 2025 at 9:21 AM
Particularly interesting talk from @rjhfmstr.bsky.social @ #ESHG25. Impressive work coming out of @unil.bsky.social 🧬🚀
🎉 Hi #ESHG2025, the Statistical Genetics Group and alumni (@zkutalik.bsky.social) is coming in force!
Check out our latest work on human genetics!
📍Come see our talks & posters, or reach out to meet us!
Check out our latest work on human genetics!
📍Come see our talks & posters, or reach out to meet us!
May 24, 2025 at 6:05 AM
🎉 Hi #ESHG2025, the Statistical Genetics Group and alumni (@zkutalik.bsky.social) is coming in force!
Check out our latest work on human genetics!
📍Come see our talks & posters, or reach out to meet us!
Check out our latest work on human genetics!
📍Come see our talks & posters, or reach out to meet us!
Reposted by Robin Hofmeister
Very excited to give a virtual talk as part of the
@eshg.bsky.social
webinar series tomorrow at 4pm (CEST). If you want to listen in, register here: wma.eventsair.com/eshg-webinar... I will talk about all the exciting things we can learn from GWAS summary statistics...
@eshg.bsky.social
webinar series tomorrow at 4pm (CEST). If you want to listen in, register here: wma.eventsair.com/eshg-webinar... I will talk about all the exciting things we can learn from GWAS summary statistics...
April 29, 2025 at 4:06 PM
Very excited to give a virtual talk as part of the
@eshg.bsky.social
webinar series tomorrow at 4pm (CEST). If you want to listen in, register here: wma.eventsair.com/eshg-webinar... I will talk about all the exciting things we can learn from GWAS summary statistics...
@eshg.bsky.social
webinar series tomorrow at 4pm (CEST). If you want to listen in, register here: wma.eventsair.com/eshg-webinar... I will talk about all the exciting things we can learn from GWAS summary statistics...
Reposted by Robin Hofmeister
🚨 New paper 🚨
Do known genetic factors for obesity and type 2 diabetes affect weight loss from GLP1-RA (Ozempic) or bariatric surgery?
🔍 10,960 people, 9 biobanks, 6 countries
🧬 Minimal genetic impact on GLP1-RA response
📉 Modest effect after surgery
www.nature.com/articles/s41...
Do known genetic factors for obesity and type 2 diabetes affect weight loss from GLP1-RA (Ozempic) or bariatric surgery?
🔍 10,960 people, 9 biobanks, 6 countries
🧬 Minimal genetic impact on GLP1-RA response
📉 Modest effect after surgery
www.nature.com/articles/s41...
Association between plausible genetic factors and weight loss from GLP1-RA and bariatric surgery - Nature Medicine
The authors found, after analyzing 10,960 individuals from 9 multiancestry biobanks across 6 countries, that genetic factors previously associated with BMI have limited impact on GLP-1 receptor agonis...
www.nature.com
April 18, 2025 at 1:32 PM
🚨 New paper 🚨
Do known genetic factors for obesity and type 2 diabetes affect weight loss from GLP1-RA (Ozempic) or bariatric surgery?
🔍 10,960 people, 9 biobanks, 6 countries
🧬 Minimal genetic impact on GLP1-RA response
📉 Modest effect after surgery
www.nature.com/articles/s41...
Do known genetic factors for obesity and type 2 diabetes affect weight loss from GLP1-RA (Ozempic) or bariatric surgery?
🔍 10,960 people, 9 biobanks, 6 countries
🧬 Minimal genetic impact on GLP1-RA response
📉 Modest effect after surgery
www.nature.com/articles/s41...
Reposted by Robin Hofmeister
After 6 (healthy) months of hiatus from social media, first post with a brand new conference announcement!! 🔥COMPUTATIONAL BIOLOGY IS EVERYWHERE! Join us in Lausanne for the first international Computational Biology Symposium! 18-19 September 2025 Registrations are OPEN! cbiosymposium.unil.ch
Computational Biology Symposium
cbiosymposium.unil.ch
March 18, 2025 at 1:09 PM
After 6 (healthy) months of hiatus from social media, first post with a brand new conference announcement!! 🔥COMPUTATIONAL BIOLOGY IS EVERYWHERE! Join us in Lausanne for the first international Computational Biology Symposium! 18-19 September 2025 Registrations are OPEN! cbiosymposium.unil.ch
Reposted by Robin Hofmeister
Only two weeks left to apply to the Leena Peltonen School of Human Genomics.
Stellar faculty, free accommodation and no registration fee.
Unique format: 20 students:20 tutors, presenting their science and learning together.
lpshg.com
Stellar faculty, free accommodation and no registration fee.
Unique format: 20 students:20 tutors, presenting their science and learning together.
lpshg.com
LPSHG – Leena Peltonen Shool Of Human Genomics
lpshg.com
February 21, 2025 at 3:21 PM
Only two weeks left to apply to the Leena Peltonen School of Human Genomics.
Stellar faculty, free accommodation and no registration fee.
Unique format: 20 students:20 tutors, presenting their science and learning together.
lpshg.com
Stellar faculty, free accommodation and no registration fee.
Unique format: 20 students:20 tutors, presenting their science and learning together.
lpshg.com
Reposted by Robin Hofmeister
Here are some cool animations I made a couple years ago for teaching DAG-based causal inference
Confounding!
Confounding!
February 20, 2025 at 9:40 PM
Here are some cool animations I made a couple years ago for teaching DAG-based causal inference
Confounding!
Confounding!
Reposted by Robin Hofmeister
EMGM2025 abstract deadline extended – 09/02 (final). Conference 8-9 April, Brest, France. Everything statistical and population genetics, genetic epidemiology, bioinformatics… Invited speakers: Céline Bon, Beatriz Cuyabano, Garrett Hellenthal. emgm2025.sciencesconf.org
53rd European Mathematical Genetics Meeting - Sciencesconf.org
emgm2025.sciencesconf.org
February 2, 2025 at 3:40 PM
EMGM2025 abstract deadline extended – 09/02 (final). Conference 8-9 April, Brest, France. Everything statistical and population genetics, genetic epidemiology, bioinformatics… Invited speakers: Céline Bon, Beatriz Cuyabano, Garrett Hellenthal. emgm2025.sciencesconf.org
Reposted by Robin Hofmeister
Just 10 days to go until the EMGM2025 abstract submission deadline!
emgm2025.sciencesconf.org?lang=en
Registration is also now up and running.
Hope to see you all in Brest
emgm2025.sciencesconf.org?lang=en
Registration is also now up and running.
Hope to see you all in Brest
53rd European Mathematical Genetics Meeting - Sciencesconf.org
emgm2025.sciencesconf.org
January 23, 2025 at 8:57 AM
Just 10 days to go until the EMGM2025 abstract submission deadline!
emgm2025.sciencesconf.org?lang=en
Registration is also now up and running.
Hope to see you all in Brest
emgm2025.sciencesconf.org?lang=en
Registration is also now up and running.
Hope to see you all in Brest
🚨 Preprint update!
We expanded our study on parent-of-origin effects with new findings from the MoBa cohort, now leveraging up to 265,000 individuals!
Discover fresh insights into the genetic architecture of early growth!
Updated preprint: www.medrxiv.org/content/10.1...
We expanded our study on parent-of-origin effects with new findings from the MoBa cohort, now leveraging up to 265,000 individuals!
Discover fresh insights into the genetic architecture of early growth!
Updated preprint: www.medrxiv.org/content/10.1...
🚨 Our preprint on parent-of-origin effects (POEs) is out!
With our novel method, we inferred the parental origin of alleles for >220,000 individuals, uncovering novel insights into genetics, evolution, and health.
👉 Read here: www.medrxiv.org/content/10.1...
👇 Highlights below!
With our novel method, we inferred the parental origin of alleles for >220,000 individuals, uncovering novel insights into genetics, evolution, and health.
👉 Read here: www.medrxiv.org/content/10.1...
👇 Highlights below!
Parent-of-Origin inference and its role in the genetic architecture of complex traits: evidence from ~220,000 individuals
Parent-of-origin effects (POEs) occur when the impact of a genetic variant depends on its parental origin. Traditionally linked to genomic imprinting, these effects are believed to have evolved from p...
www.medrxiv.org
January 21, 2025 at 1:52 PM
🚨 Preprint update!
We expanded our study on parent-of-origin effects with new findings from the MoBa cohort, now leveraging up to 265,000 individuals!
Discover fresh insights into the genetic architecture of early growth!
Updated preprint: www.medrxiv.org/content/10.1...
We expanded our study on parent-of-origin effects with new findings from the MoBa cohort, now leveraging up to 265,000 individuals!
Discover fresh insights into the genetic architecture of early growth!
Updated preprint: www.medrxiv.org/content/10.1...
Reposted by Robin Hofmeister
Abstract submissions for the European Mathematical Genetics Meeting are open! emgm2025.sciencesconf.org Deadline February 2nd, looking forward to seeing your proposals. Meeting is in Brest, France, 8-9 April
53rd European Mathematical Genetics Meeting - Sciencesconf.org
emgm2025.sciencesconf.org
January 6, 2025 at 4:08 PM
Abstract submissions for the European Mathematical Genetics Meeting are open! emgm2025.sciencesconf.org Deadline February 2nd, looking forward to seeing your proposals. Meeting is in Brest, France, 8-9 April
Reposted by Robin Hofmeister
Just out in @naturehumbehav.bsky.social !
We focused on the causes & impact of self-report error in the UK Biobank. We found that reporting error does not occur at random, is not independent of other participation behaviours, and can complicate the interpretation of GWA findings
shorturl.at/N4Qc6
We focused on the causes & impact of self-report error in the UK Biobank. We found that reporting error does not occur at random, is not independent of other participation behaviours, and can complicate the interpretation of GWA findings
shorturl.at/N4Qc6
The impact of self-report inaccuracy in the UK Biobank and its interplay with selective participation - Nature Human Behaviour
Biobank data are extensively used. Schoeler and colleagues show that self-report inaccuracy and selective participation are sources of poor reproducibility for biobank-scale research.
shorturl.at
December 19, 2024 at 8:09 AM
Just out in @naturehumbehav.bsky.social !
We focused on the causes & impact of self-report error in the UK Biobank. We found that reporting error does not occur at random, is not independent of other participation behaviours, and can complicate the interpretation of GWA findings
shorturl.at/N4Qc6
We focused on the causes & impact of self-report error in the UK Biobank. We found that reporting error does not occur at random, is not independent of other participation behaviours, and can complicate the interpretation of GWA findings
shorturl.at/N4Qc6
Reposted by Robin Hofmeister
🌟 Exciting news: The Leena Peltonen School of Human Genetics returns in 2025!
We're excited to bring PhD students together with an all-star list of leaders in human genetics.
📅 July 27-31, 2025
📍 Wellcome Genome Campus, UK
📝 Apply by March 7 at www.lpshg.com
We're excited to bring PhD students together with an all-star list of leaders in human genetics.
📅 July 27-31, 2025
📍 Wellcome Genome Campus, UK
📝 Apply by March 7 at www.lpshg.com
December 18, 2024 at 12:42 PM
🌟 Exciting news: The Leena Peltonen School of Human Genetics returns in 2025!
We're excited to bring PhD students together with an all-star list of leaders in human genetics.
📅 July 27-31, 2025
📍 Wellcome Genome Campus, UK
📝 Apply by March 7 at www.lpshg.com
We're excited to bring PhD students together with an all-star list of leaders in human genetics.
📅 July 27-31, 2025
📍 Wellcome Genome Campus, UK
📝 Apply by March 7 at www.lpshg.com
🚨 Our preprint on parent-of-origin effects (POEs) is out!
With our novel method, we inferred the parental origin of alleles for >220,000 individuals, uncovering novel insights into genetics, evolution, and health.
👉 Read here: www.medrxiv.org/content/10.1...
👇 Highlights below!
With our novel method, we inferred the parental origin of alleles for >220,000 individuals, uncovering novel insights into genetics, evolution, and health.
👉 Read here: www.medrxiv.org/content/10.1...
👇 Highlights below!
Parent-of-Origin inference and its role in the genetic architecture of complex traits: evidence from ~220,000 individuals
Parent-of-origin effects (POEs) occur when the impact of a genetic variant depends on its parental origin. Traditionally linked to genomic imprinting, these effects are believed to have evolved from p...
www.medrxiv.org
December 6, 2024 at 12:12 PM
🚨 Our preprint on parent-of-origin effects (POEs) is out!
With our novel method, we inferred the parental origin of alleles for >220,000 individuals, uncovering novel insights into genetics, evolution, and health.
👉 Read here: www.medrxiv.org/content/10.1...
👇 Highlights below!
With our novel method, we inferred the parental origin of alleles for >220,000 individuals, uncovering novel insights into genetics, evolution, and health.
👉 Read here: www.medrxiv.org/content/10.1...
👇 Highlights below!