Richard Held
@rgsheld.bsky.social
Neuroscientist / synaptic physiologist interested in protein topography and cellular signal transduction. Ephys in the past, cryoET now, mouse genetics forever.
https://scholar.google.com/citations?hl=en&user=ESpBK1AAAAAJ
https://scholar.google.com/citations?hl=en&user=ESpBK1AAAAAJ
Important to remember how fast the fusion process actually is! Millisecond experimental temporal resolution is hard to achieve but synchronous fusion is happening within hundreds of microseconds of action potential onset.
www.nature.com/articles/384...
www.nature.com/articles/384...
Timing of neurotransmission at fast synapses in the mammalian brain - Nature
Nature - Timing of neurotransmission at fast synapses in the mammalian brain
www.nature.com
November 7, 2025 at 9:50 PM
Important to remember how fast the fusion process actually is! Millisecond experimental temporal resolution is hard to achieve but synchronous fusion is happening within hundreds of microseconds of action potential onset.
www.nature.com/articles/384...
www.nature.com/articles/384...
I'm not entirely on board with the proposed temporal sequence but I think the size of the dataset convincingly demonstrates the presence of "small" and "large" membrane proximal vesicle populations. A more tempting model imo would be that these small vesicles preferentially fuse asynchronously.
November 7, 2025 at 9:50 PM
I'm not entirely on board with the proposed temporal sequence but I think the size of the dataset convincingly demonstrates the presence of "small" and "large" membrane proximal vesicle populations. A more tempting model imo would be that these small vesicles preferentially fuse asynchronously.
November 2, 2025 at 2:28 AM
I believe @cmholab.bsky.social mentioned in a talk that they did something to assess this for plasmodium.
June 9, 2025 at 8:30 PM
I believe @cmholab.bsky.social mentioned in a talk that they did something to assess this for plasmodium.