✅ Takeaway: For optimal protection, vaccination should be completed BEFORE starting lymphoma treatment with B-cell depleting agent, followed by a booster AFTERWARD.
#CovidVaccine #Lymsm
www.frontiersin.org/journals/imm...

🔹 Key findings: During lymphoma treatment, CD4, CD8, and B-cell counts dropped. While T-cell responses to SARS-CoV-2 remained intact, antibody production was significantly reduced when vaccinated during therapy. In contrast, patients vaccinated before treatment had a much stronger antibody response.

That’s why we launched the Lymphocovac study—a prospective, case-control, multicenter trial (NCT05050461) to understand how these treatments impact T-cell and antibody responses to COVID-19 mRNA vaccines.

www.frontiersin.org/journals/imm...

But vaccination remains a challenge for these patients. Anti-CD20 therapies suppress the immune system, making it harder to mount an effective response.

www.sciencedirect.com/science/arti...

Patients with B-cell lymphoma were initially at high risk of severe and prolonged #COVID19, especially those on B-cell-depleting treatments. Thankfully, with the rise of Omicron, antiviral therapies, and widespread vaccination, COVID-19 mortality dropped to 6%
onlinelibrary.wiley.com/doi/10.1002/...

I am very happy this prospective study is finally out! Congratulations for the excellent work on the manuscript. Et à bientôt j’espère !

Thanks. I am also one of the co-authors and I am excited to finally see this great collaborative study published in your journal. 😊

Thank you, John!