Raquel Garza
@raquelgarza.bsky.social
Researcher 🧬👩💻 (she/her)
Here for transposons, bioinformatics, and brains.
Here for transposons, bioinformatics, and brains.
November 20, 2025 at 10:49 AM
Always a joy to join #EMBOMobileGenome -A week full of cool nature’s quirks and science along the friendliest crowd 🧬 Happy to have shared our work on ERVs in human brain evolution (talk by @jakobssonlab.bsky.social) and Parkinson’s disease (poster by yours truly) 🧠
#ASAP @jakobssonasap.bsky.social
#ASAP @jakobssonasap.bsky.social
November 7, 2025 at 11:10 AM
Always a joy to join #EMBOMobileGenome -A week full of cool nature’s quirks and science along the friendliest crowd 🧬 Happy to have shared our work on ERVs in human brain evolution (talk by @jakobssonlab.bsky.social) and Parkinson’s disease (poster by yours truly) 🧠
#ASAP @jakobssonasap.bsky.social
#ASAP @jakobssonasap.bsky.social
Reposted by Raquel Garza
#EMBOMobileGenome Session 2 on transposon regulation 🧬
➡️'Epigenetic control of transcribed retroelements by the HUSH complex and associated factors' presented by Christopher Douse (Lund University, Sweden)
We love a good Q&A session as well! 🙋🏼
@chdouse.bsky.social @lundstem.bsky.social @embl.org
➡️'Epigenetic control of transcribed retroelements by the HUSH complex and associated factors' presented by Christopher Douse (Lund University, Sweden)
We love a good Q&A session as well! 🙋🏼
@chdouse.bsky.social @lundstem.bsky.social @embl.org
November 5, 2025 at 1:30 PM
#EMBOMobileGenome Session 2 on transposon regulation 🧬
➡️'Epigenetic control of transcribed retroelements by the HUSH complex and associated factors' presented by Christopher Douse (Lund University, Sweden)
We love a good Q&A session as well! 🙋🏼
@chdouse.bsky.social @lundstem.bsky.social @embl.org
➡️'Epigenetic control of transcribed retroelements by the HUSH complex and associated factors' presented by Christopher Douse (Lund University, Sweden)
We love a good Q&A session as well! 🙋🏼
@chdouse.bsky.social @lundstem.bsky.social @embl.org
Reposted by Raquel Garza
Had an absolute blast presenting my “Last Minute Breakthrough talk” at #EMBOmobilegenome today! 🔥 What an incredible crowd, the energy in the room was unreal. Huge thanks to the organizers for selecting me and to everyone who came, asked questions, and made it such a fun session! 🙌
November 5, 2025 at 6:58 PM
Had an absolute blast presenting my “Last Minute Breakthrough talk” at #EMBOmobilegenome today! 🔥 What an incredible crowd, the energy in the room was unreal. Huge thanks to the organizers for selecting me and to everyone who came, asked questions, and made it such a fun session! 🙌
Reposted by Raquel Garza
@raquelgarza.bsky.social from the Jakobsson Lab presented our recent work on single-cell omics (transcriptomics+ proteomics) within our ASAP project at the SciLifeLab Lund day. This work is being done in collaboration with #BioMS and @scilifelab.se. We are looking forward to the discoveries ahead 🌟
October 23, 2025 at 3:04 PM
@raquelgarza.bsky.social from the Jakobsson Lab presented our recent work on single-cell omics (transcriptomics+ proteomics) within our ASAP project at the SciLifeLab Lund day. This work is being done in collaboration with #BioMS and @scilifelab.se. We are looking forward to the discoveries ahead 🌟
Reposted by Raquel Garza
Thrilled to share our story in its final form! nature.com/articles/s41... 💥 After ~10 years, we show that BMAL1 represses transposons via chromatin regulation in embryonic stem cells—rather than circadian rhythms as in adult tissues.
https://nature.com/articles/s41467-025-63778-4💥
September 10, 2025 at 2:26 PM
Thrilled to share our story in its final form! nature.com/articles/s41... 💥 After ~10 years, we show that BMAL1 represses transposons via chromatin regulation in embryonic stem cells—rather than circadian rhythms as in adult tissues.
💥 New preprint! 💥
We show that transposons are directly linked to a cell-type and region specific inflammatory state in Parkinson’s Disease 🧠🦠
What a team @jakobssonasap.bsky.social! Funded by @asapresearch.parkinsonsroadmap.org
#Parkinsons #Neuroinflammation #TEworldwide #singlecell #TEs
We show that transposons are directly linked to a cell-type and region specific inflammatory state in Parkinson’s Disease 🧠🦠
What a team @jakobssonasap.bsky.social! Funded by @asapresearch.parkinsonsroadmap.org
#Parkinsons #Neuroinflammation #TEworldwide #singlecell #TEs
New preprint from my lab! We describe how transposable elements are activated in Parkinson’s disease, which is linked to an interferon response. We believe this study significantly advances our understanding of transposons and their role in human brains.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Activation of transposable elements is linked to a region- and cell-type-specific interferon response in Parkinson's disease
Parkinson's disease (PD) is a common age-related neurodegenerative disorder involving a neuroinflammatory response, the cause of which remains unclear. Transposable elements (TE) have been linked to i...
www.biorxiv.org
September 8, 2025 at 7:42 PM
💥 New preprint! 💥
We show that transposons are directly linked to a cell-type and region specific inflammatory state in Parkinson’s Disease 🧠🦠
What a team @jakobssonasap.bsky.social! Funded by @asapresearch.parkinsonsroadmap.org
#Parkinsons #Neuroinflammation #TEworldwide #singlecell #TEs
We show that transposons are directly linked to a cell-type and region specific inflammatory state in Parkinson’s Disease 🧠🦠
What a team @jakobssonasap.bsky.social! Funded by @asapresearch.parkinsonsroadmap.org
#Parkinsons #Neuroinflammation #TEworldwide #singlecell #TEs
Cheers @anitaada.bsky.social for some more awesome science together 🍾🌟
Check out our latest work on L1 retrotransposons and their cis acting effect in early brain development 🧠 www.cell.com/cell-genomic...
Check out our latest work on L1 retrotransposons and their cis acting effect in early brain development 🧠 www.cell.com/cell-genomic...
August 31, 2025 at 3:44 PM
Cheers @anitaada.bsky.social for some more awesome science together 🍾🌟
Check out our latest work on L1 retrotransposons and their cis acting effect in early brain development 🧠 www.cell.com/cell-genomic...
Check out our latest work on L1 retrotransposons and their cis acting effect in early brain development 🧠 www.cell.com/cell-genomic...
Excited to share our latest work!! 🌟🌟
Thank you for all the amazing work and congratulations to @anitaada.bsky.social and all the coauthors! 🍾
Thank you for all the amazing work and congratulations to @anitaada.bsky.social and all the coauthors! 🍾
New paper from our lab! We found that LINE-1 transposons contribute to early human brain development.
Funded by @asapresearch.parkinsonsroadmap.org
www.cell.com/cell-genomic...
Funded by @asapresearch.parkinsonsroadmap.org
www.cell.com/cell-genomic...
LINE-1 retrotransposons mediate cis-acting transcriptional control in human pluripotent stem cells and regulate early brain development
Adami et al. demonstrate that evolutionarily young L1s are expressed in human pluripotent
stem cells and are dynamically regulated throughout neural differentiation. The study
examines the role of L1s...
www.cell.com
August 24, 2025 at 7:55 PM
Excited to share our latest work!! 🌟🌟
Thank you for all the amazing work and congratulations to @anitaada.bsky.social and all the coauthors! 🍾
Thank you for all the amazing work and congratulations to @anitaada.bsky.social and all the coauthors! 🍾
Reposted by Raquel Garza
New paper from our lab! We found that LINE-1 transposons contribute to early human brain development.
Funded by @asapresearch.parkinsonsroadmap.org
www.cell.com/cell-genomic...
Funded by @asapresearch.parkinsonsroadmap.org
www.cell.com/cell-genomic...
LINE-1 retrotransposons mediate cis-acting transcriptional control in human pluripotent stem cells and regulate early brain development
Adami et al. demonstrate that evolutionarily young L1s are expressed in human pluripotent
stem cells and are dynamically regulated throughout neural differentiation. The study
examines the role of L1s...
www.cell.com
August 23, 2025 at 9:47 AM
New paper from our lab! We found that LINE-1 transposons contribute to early human brain development.
Funded by @asapresearch.parkinsonsroadmap.org
www.cell.com/cell-genomic...
Funded by @asapresearch.parkinsonsroadmap.org
www.cell.com/cell-genomic...
Reposted by Raquel Garza
Very happy to share our protocols paper for CELLO-seq. This will make single cell long read RNA-seq more accessible and provides analysis guidelines. We hope this helps the #transposon #TEsky community and folks working on #singleCell isoform and allelic #gene expression. doi.org/10.1038/s415...
Long-read RNA sequencing of transposable elements from single cells using CELLO-seq - Nature Protocols
Single-cell long-read RNA sequencing enables the high-fidelity mapping of single-cell expression data from highly sequence-similar transposable elements to unique genomic loci by correcting errors fro...
doi.org
July 16, 2025 at 4:55 PM
Very happy to share our protocols paper for CELLO-seq. This will make single cell long read RNA-seq more accessible and provides analysis guidelines. We hope this helps the #transposon #TEsky community and folks working on #singleCell isoform and allelic #gene expression. doi.org/10.1038/s415...
Reposted by Raquel Garza
⏰ Abstract deadline for 'The mobile genome' is 29 July!
👉 https://s.embl.org/mge25-01-bl
Join us 4–7 Nov 2025 at EMBL Heidelberg (or online) to explore the impact of TEs across biology. 🧬🔍
⭐🧑🏼🔬 24 talks + 15 flash talks from posters – don't miss out!
#EMBOMobileGenome
👉 https://s.embl.org/mge25-01-bl
Join us 4–7 Nov 2025 at EMBL Heidelberg (or online) to explore the impact of TEs across biology. 🧬🔍
⭐🧑🏼🔬 24 talks + 15 flash talks from posters – don't miss out!
#EMBOMobileGenome
June 18, 2025 at 8:14 AM
⏰ Abstract deadline for 'The mobile genome' is 29 July!
👉 https://s.embl.org/mge25-01-bl
Join us 4–7 Nov 2025 at EMBL Heidelberg (or online) to explore the impact of TEs across biology. 🧬🔍
⭐🧑🏼🔬 24 talks + 15 flash talks from posters – don't miss out!
#EMBOMobileGenome
👉 https://s.embl.org/mge25-01-bl
Join us 4–7 Nov 2025 at EMBL Heidelberg (or online) to explore the impact of TEs across biology. 🧬🔍
⭐🧑🏼🔬 24 talks + 15 flash talks from posters – don't miss out!
#EMBOMobileGenome
These past 2 months as a visiting scholar at KU Leuven flew by! It has been so enriching to work side by side with #TeamVoet on @jakobssonasap.bsky.social research into Transposable Elements & Parkinson’s Disease 🧠🧬 Excited for what’s next!
#ParkinsonsDisease #MJFF #ASAP #CRN #TransposableElements
#ParkinsonsDisease #MJFF #ASAP #CRN #TransposableElements
July 9, 2025 at 3:20 PM
These past 2 months as a visiting scholar at KU Leuven flew by! It has been so enriching to work side by side with #TeamVoet on @jakobssonasap.bsky.social research into Transposable Elements & Parkinson’s Disease 🧠🧬 Excited for what’s next!
#ParkinsonsDisease #MJFF #ASAP #CRN #TransposableElements
#ParkinsonsDisease #MJFF #ASAP #CRN #TransposableElements
Reposted by Raquel Garza
New preprint from our lab! Why is not everyone working on Transposons?
Loss of H3K9me3 maintenance in human neural progenitor cells leads to transcriptional activation of L1 retrotransposons
www.biorxiv.org/content/10.1...
Loss of H3K9me3 maintenance in human neural progenitor cells leads to transcriptional activation of L1 retrotransposons
www.biorxiv.org/content/10.1...
Loss of H3K9me3 maintenance in human neural progenitor cells leads to transcriptional activation of L1 retrotransposons
Heterochromatin is characterised by an inaccessibility to the transcriptional machinery and associated with the histone mark H3K9me3. Heterochromatin erosion is a hallmark of human ageing and H3K9me3 ...
www.biorxiv.org
March 29, 2025 at 10:05 AM
New preprint from our lab! Why is not everyone working on Transposons?
Loss of H3K9me3 maintenance in human neural progenitor cells leads to transcriptional activation of L1 retrotransposons
www.biorxiv.org/content/10.1...
Loss of H3K9me3 maintenance in human neural progenitor cells leads to transcriptional activation of L1 retrotransposons
www.biorxiv.org/content/10.1...
Reposted by Raquel Garza
Last week, some of us from Team Jakobsson had a great time in Arizona at the 2025 CRN Collaborative Meeting! Plenty of insightful talks and networking. Shoutout to @kirkebylab.bsky.social for a fantastic talk on PSC-based therapies and models of PD 🌟🧬🏜️ #CRNPhoenix2025 @asapresearch.bsky.social
March 18, 2025 at 3:40 PM
Last week, some of us from Team Jakobsson had a great time in Arizona at the 2025 CRN Collaborative Meeting! Plenty of insightful talks and networking. Shoutout to @kirkebylab.bsky.social for a fantastic talk on PSC-based therapies and models of PD 🌟🧬🏜️ #CRNPhoenix2025 @asapresearch.bsky.social
Popcorn worthy research at #CRNPhoenix2025 with
@jakobssonasap.bsky.social 🍿
#ParkinsonsDisease #PD #TEsky
@jakobssonasap.bsky.social 🍿
#ParkinsonsDisease #PD #TEsky
March 12, 2025 at 9:45 PM
Popcorn worthy research at #CRNPhoenix2025 with
@jakobssonasap.bsky.social 🍿
#ParkinsonsDisease #PD #TEsky
@jakobssonasap.bsky.social 🍿
#ParkinsonsDisease #PD #TEsky
Reposted by Raquel Garza
Super happy to announce the latest work from my lab together with Hemali Phatnani @nygenome.org & NYGC ALS Consortium!
We've combined ALS patient profiling (100s!), ML classifiers and matched bulk/single-cell data to dive into ALS Molecular Subtypes
#NIHfundedResearch
www.cell.com/cell-reports...
We've combined ALS patient profiling (100s!), ML classifiers and matched bulk/single-cell data to dive into ALS Molecular Subtypes
#NIHfundedResearch
www.cell.com/cell-reports...
ALS molecular subtypes are a combination of cellular and pathological features learned by deep multiomics classifiers
O’Neill et al. present a deep exploration of molecular subtypes in ALS postmortem
tissues from the NYGC ALS Consortium. Matched bulk and single-cell profiles demonstrate
that ALS subtypes are a combin...
www.cell.com
March 10, 2025 at 9:49 PM
Super happy to announce the latest work from my lab together with Hemali Phatnani @nygenome.org & NYGC ALS Consortium!
We've combined ALS patient profiling (100s!), ML classifiers and matched bulk/single-cell data to dive into ALS Molecular Subtypes
#NIHfundedResearch
www.cell.com/cell-reports...
We've combined ALS patient profiling (100s!), ML classifiers and matched bulk/single-cell data to dive into ALS Molecular Subtypes
#NIHfundedResearch
www.cell.com/cell-reports...
Reposted by Raquel Garza
In this paper, CRN Team @jacksonlab.bsky.social found that LINE-1 transposable elements contribute to the complexity of the transcriptome in human pluripotent stem cells by acting as alternative promoters for approximately 100 genes.
Check out the full #preprint: shorturl.at/TJ9BK
Check out the full #preprint: shorturl.at/TJ9BK
February 26, 2025 at 4:38 PM
In this paper, CRN Team @jacksonlab.bsky.social found that LINE-1 transposable elements contribute to the complexity of the transcriptome in human pluripotent stem cells by acting as alternative promoters for approximately 100 genes.
Check out the full #preprint: shorturl.at/TJ9BK
Check out the full #preprint: shorturl.at/TJ9BK
Congrats @marliesoomen.bsky.social! 🧬🍾 Had been looking forward to see this paper since I heard of it in CSHL 🍂 Having it for JC next week 🤓
Very excited to share our paper on Gene and Transposable Element expression in mammalian preimplantation development, online today! www.cell.com/cell/fulltex...
A short thread to highlight some of our findings 🧵
A short thread to highlight some of our findings 🧵
January 23, 2025 at 6:46 PM
Congrats @marliesoomen.bsky.social! 🧬🍾 Had been looking forward to see this paper since I heard of it in CSHL 🍂 Having it for JC next week 🤓
Reposted by Raquel Garza
🧠🔬 Great meeting last Friday in Copenhagen between the Kirkeby and Jakobsson labs — exciting experiments coming up to investigate transposons in PD in vitro models! @asapresearch.bsky.social @kirkebylab.bsky.social @jakobssonlab.bsky.social
January 20, 2025 at 4:41 PM
🧠🔬 Great meeting last Friday in Copenhagen between the Kirkeby and Jakobsson labs — exciting experiments coming up to investigate transposons in PD in vitro models! @asapresearch.bsky.social @kirkebylab.bsky.social @jakobssonlab.bsky.social
We profiled the effects of our CRISPRi system targeting young L1 elements in human pluripotency & brain development. These elements deeply impact our transcriptome, but also have very distinct effects on their nearby genome. Check it out!! 🧬👾
#TEsky #CRISPR #L1 #development #epigenetics
#TEsky #CRISPR #L1 #development #epigenetics
🚨 New pre-print from Team Jakobsson! LINE-1 retrotransposons regulate the exit of human pluripotency and early brain development.
This work was led by @anitaada.bsky.social, @raquelgarza.bsky.social and @jakobssonlab.bsky.social from the Jakobsson Lab.
www.biorxiv.org/content/10.1...
This work was led by @anitaada.bsky.social, @raquelgarza.bsky.social and @jakobssonlab.bsky.social from the Jakobsson Lab.
www.biorxiv.org/content/10.1...
LINE-1 retrotransposons regulate the exit of human pluripotency and early brain development
Long interspersed nuclear element 1 (L1) retrotransposons represent a vast source of divergent genetic information. However, mechanistic analysis of whether and how L1s contribute to human development...
www.biorxiv.org
January 18, 2025 at 11:30 AM
We profiled the effects of our CRISPRi system targeting young L1 elements in human pluripotency & brain development. These elements deeply impact our transcriptome, but also have very distinct effects on their nearby genome. Check it out!! 🧬👾
#TEsky #CRISPR #L1 #development #epigenetics
#TEsky #CRISPR #L1 #development #epigenetics
Reposted by Raquel Garza
CSH Asia is organising its first transposon meeting. Don't miss out on some great science and a fantastic trip. Abstract deadline fast approaching.
www.csh-asia.org?content/2544
www.csh-asia.org?content/2544
January 9, 2025 at 11:35 AM
CSH Asia is organising its first transposon meeting. Don't miss out on some great science and a fantastic trip. Abstract deadline fast approaching.
www.csh-asia.org?content/2544
www.csh-asia.org?content/2544
Secret santa @jakobssonlab.bsky.social 🧬🎄
December 13, 2024 at 2:30 PM
Secret santa @jakobssonlab.bsky.social 🧬🎄
Reposted by Raquel Garza
Tracking transposable element (TE) activity in genomics data can be a pain, but there are solutions! Our lab built TEtranscripts -- which we've updated to work for small RNAs (TEsmall), bulk RNA at the locus level (TElocal), and in single-cell data (TEsingle). Check it out!
www.mghlab.org/software
www.mghlab.org/software
November 18, 2024 at 11:14 PM
Tracking transposable element (TE) activity in genomics data can be a pain, but there are solutions! Our lab built TEtranscripts -- which we've updated to work for small RNAs (TEsmall), bulk RNA at the locus level (TElocal), and in single-cell data (TEsingle). Check it out!
www.mghlab.org/software
www.mghlab.org/software
💥🦊 So proud of being part of this team!
We're thrilled to announce that our project has been funded by @asapresearch.bsky.social in partnership with the Michael J. Fox Foundation! 🚀 Excited to continue exploring the role of transposable elements in Parkinson’s disease. Learn more here:
www.lunduniversity.lu.se/article/52-m...
www.lunduniversity.lu.se/article/52-m...
52 Million SEK towards uncovering genetic drivers of Parkinson’s Disease
Lund University. Jumping genes, or transposable elements, make up nearly half of the human genome. These mobile sequences can shift within the genome and are known to influence various biological proc...
www.lunduniversity.lu.se
December 5, 2024 at 5:24 PM
💥🦊 So proud of being part of this team!