Raphael Mangione
@raphaelmngn.bsky.social
Postdoc @Whitehouse lab (MSKCC, NY). Previous: PhD candidate @Palancade lab (IJM, Paris) | DNA:RNA hybrids - DNA Replication - Transcription
Reposted by Raphael Mangione
Much grateful to @agencerecherche.bsky.social , @fondationarc.bsky.social and Ligue Nationale contre le Cancer for funding this project ! (7/8)
March 11, 2025 at 4:42 PM
Much grateful to @agencerecherche.bsky.social , @fondationarc.bsky.social and Ligue Nationale contre le Cancer for funding this project ! (7/8)
Reposted by Raphael Mangione
Congratulations to first author @raphaelmngn.bsky.social and many thanks to all our great collaborators 🧑🎓 - Rodney Rothstein @columbiamed.bsky.social, Sergio de Almeida @gimmfoundation.bsky.social, Peter Stirling @BCCancer and Pierre-Henri Gaillard @crcm.bsky.social (6/8)
March 11, 2025 at 4:42 PM
Congratulations to first author @raphaelmngn.bsky.social and many thanks to all our great collaborators 🧑🎓 - Rodney Rothstein @columbiamed.bsky.social, Sergio de Almeida @gimmfoundation.bsky.social, Peter Stirling @BCCancer and Pierre-Henri Gaillard @crcm.bsky.social (6/8)
Reposted by Raphael Mangione
Such « post-lesion » hybrids can be detected in yeast and human cells, yet they do not detectably impact genome stability, as opposed to « pre-lesion » hybrids - a revisited classification? (5/8)
March 11, 2025 at 4:42 PM
Such « post-lesion » hybrids can be detected in yeast and human cells, yet they do not detectably impact genome stability, as opposed to « pre-lesion » hybrids - a revisited classification? (5/8)
Reposted by Raphael Mangione
For example, focusing on Okazaki fragments (OF) processing, we found that the accumulation of unprocessed flaps or unligated OF termini is the source of hybrid formation 🧬 (4/8)
March 11, 2025 at 4:42 PM
For example, focusing on Okazaki fragments (OF) processing, we found that the accumulation of unprocessed flaps or unligated OF termini is the source of hybrid formation 🧬 (4/8)
Reposted by Raphael Mangione
We identified several situations where DNA:RNA hybrids are associated with genetic instability – strikingly, in most cases, DNA lesions appear to precede hybrid formation 🔃 (3/8)
March 11, 2025 at 4:42 PM
We identified several situations where DNA:RNA hybrids are associated with genetic instability – strikingly, in most cases, DNA lesions appear to precede hybrid formation 🔃 (3/8)
Reposted by Raphael Mangione
In this study, we systematically explored the relationships between DNA:RNA hybrid formation and genetic instability, through a suite of genetic screens in yeast 🧬 (2/8)
March 11, 2025 at 4:42 PM
In this study, we systematically explored the relationships between DNA:RNA hybrid formation and genetic instability, through a suite of genetic screens in yeast 🧬 (2/8)