#Neuroscience #BrainNetworks #Dementia #EarlyOnsetDementia #Neurodegeneration #NetworkResilience #ClinicalNeuroscience #GraphTheory #NetworkNeuroscience #ComputationalNeuroscience

If you’re working in cognitive neuroscience, network approaches to brain disorders, early‐onset dementia, connectomics or translational neurology, let’s collaborate to make a real impact.

Thanks to my co-authors (Hema Nawani, Sredha Sunil) and reviewers, and a huge thank you to our professor Veeky Baths for his guidance and support throughout this work.

I believe this work contributes to bridging neuroscience, network theory, and clinical neurology, and invites discussion on how we can design interventions that strengthen brain network resilience in dementia.

-Gaps&opportunities:The need for models that integrate network resilience, longitudinal data, multimodal connectivity(structural+functional+ electrophysiological)&early‐onset cohorts;translational potential for biomarkers&interventions that support network integrity rather than just reduce pathology

- Review of methodological findings: how graph‐theoretic metrics (clustering coefficient, global/local efficiency, modularity, assortativity, small‐worldness) are being applied to neuroimaging and electrophysiology in early dementia.

- The concept of network resilience as a key lens: rather than only asking “where damage occurs”, the paper argues we should ask “how the network topology fails to compensate, reorganise or maintain function under pathology”. This shifts the view to resilience‐focused models.

-Evidence that brain networks lose their optimal organisational properties(e.g., balance of segregation & integration)in early‐onset dementia, reflecting decline in network resilience. For e.g.,previous work has shown disrupted segregation/integration in large‐scale brain networks in Alzheimer’s/MCI

In this review, we highlight several important insights:
-A summary of how early‐onset forms of dementia(including Alzheimer’s disease, frontotemporal dementia(FTD),and behavioral variant FTD)show disruption in brain network topology(both structural and functional)rather than purely focal pathology.

If it doesn’t eat up your time, do a ~10-15 min, or less than that, virtual meeting with the responders.