Ralitsa Madsen
@ralitsamadsen.bsky.social
UKRI Future Leaders Fellow @MRC PPU, University of Dundee. Passionate about quantitative cell signalling, systems biology, human disease mechanisms, Open Science and research integrity. Incurably curious and obsessed with PI3K signalling, in particular!
Reposted by Ralitsa Madsen
An intuitive explanation:
At fast growth, protein clearance rates are very similar across the proteome (green distribution below).
At slow growth, protein clearance rates vary widely across the proteome (purple distribution below).
bsky.app/profile/andr...
At fast growth, protein clearance rates are very similar across the proteome (green distribution below).
At slow growth, protein clearance rates vary widely across the proteome (purple distribution below).
bsky.app/profile/andr...
When comparing growing and non-growing cells, the difference in clearance rates is more substantial for long lived proteins, and thus their abundance is reduced in the growing state unless synthesis rates compensate. We find this compensation is insufficient to explain these changes.
February 13, 2025 at 1:20 PM
An intuitive explanation:
At fast growth, protein clearance rates are very similar across the proteome (green distribution below).
At slow growth, protein clearance rates vary widely across the proteome (purple distribution below).
bsky.app/profile/andr...
At fast growth, protein clearance rates are very similar across the proteome (green distribution below).
At slow growth, protein clearance rates vary widely across the proteome (purple distribution below).
bsky.app/profile/andr...
Reposted by Ralitsa Madsen
Members of the U.K. and international scientific community are invited to sign to show their support: docs.google.com/forms/d/e/1F...
Open letter to the President of the Royal Society – time to stand up for your values
If you wish to show your support for the letter below regarding apparent inaction by the Royal Society in the face of breaches of its code of conduct by Elon Musk FRS, please sign below. I invite anyo...
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February 11, 2025 at 5:17 PM
Members of the U.K. and international scientific community are invited to sign to show their support: docs.google.com/forms/d/e/1F...
Thank you so much!
January 8, 2025 at 11:16 AM
Thank you so much!
You’re much better at titles than me - this sounds much better than anything I could come up with 🤣 might steal!
January 7, 2025 at 11:08 PM
You’re much better at titles than me - this sounds much better than anything I could come up with 🤣 might steal!