Rahul Gupta
@rahulg603.bsky.social
Final year MD/PhD Student at Harvard-MIT. PhD co-advised by Vamsi Mootha and Ben Neale. Interested in statistical genetics, mitochondrial biology, and disease mechanism.
See more at gupta.bio
See more at gupta.bio
Pinned
Rahul Gupta
@rahulg603.bsky.social
· Aug 20
The case for abstraction in biology
One of the most challenging questions in all of biology is how to make sense of complex systems. This question is becoming increasingly relevant as advances in sequencing technologies decrease the cos...
emergentpropertiesblog.com
After years of chats, friends from my MD/PhD program and I launched a nerdy blog about science + medicine.
We explore everything from evolutionary theory to big data in science. @kaitavjeet.bsky.social just posted on the power of abstraction in biology 🧫
emergentpropertiesblog.com/2025/08/19/a...
We explore everything from evolutionary theory to big data in science. @kaitavjeet.bsky.social just posted on the power of abstraction in biology 🧫
emergentpropertiesblog.com/2025/08/19/a...
Reposted by Rahul Gupta
Thrilled to share our new @natcomms.nature.com paper on local ancestry informed allele frequencies in gnomAD, which are live now on the browser! Check out my stellar PhD student @pragskore.bsky.social’s Bluetorial on how this brings finer detail to variant interpretation 🧬🖥️
📃 We’re excited to share our latest work, now published in Nature Communications — a major update to the Genome Aggregation Database (gnomAD) that improves allele frequency resolution for two gnomAD-defined genetic ancestry groups using local ancestry inference (LAI).
Improved allele frequencies in gnomAD through local ancestry inference - Nature Communications
This study incorporates local ancestry into the Genome Aggregation Database (gnomAD) to improve allele frequency estimates for admixed populations, enhancing variant interpretation and enabling more accurate and equitable genomic research and clinical care.
www.nature.com
October 6, 2025 at 6:44 PM
Thrilled to share our new @natcomms.nature.com paper on local ancestry informed allele frequencies in gnomAD, which are live now on the browser! Check out my stellar PhD student @pragskore.bsky.social’s Bluetorial on how this brings finer detail to variant interpretation 🧬🖥️
How do experts gain intuition?💡
I argue:
1. expert intuition (“fast”) = pattern-matching on past experiences
2. careful reasoning (“slow”) = confronting a new scenario with step-wise thinking
3. wise decision-making toggles between both styles
Read the new post: tinyurl.com/28tb33fc
I argue:
1. expert intuition (“fast”) = pattern-matching on past experiences
2. careful reasoning (“slow”) = confronting a new scenario with step-wise thinking
3. wise decision-making toggles between both styles
Read the new post: tinyurl.com/28tb33fc
The basis of expert intuition
Have you ever thought about what makes someone an “expert” at something? Is it their ability to carefully and correctly respond to a scenario, or is it their ability to complete a task intuitively and...
www.emergentpropertiesblog.com
October 4, 2025 at 8:49 PM
How do experts gain intuition?💡
I argue:
1. expert intuition (“fast”) = pattern-matching on past experiences
2. careful reasoning (“slow”) = confronting a new scenario with step-wise thinking
3. wise decision-making toggles between both styles
Read the new post: tinyurl.com/28tb33fc
I argue:
1. expert intuition (“fast”) = pattern-matching on past experiences
2. careful reasoning (“slow”) = confronting a new scenario with step-wise thinking
3. wise decision-making toggles between both styles
Read the new post: tinyurl.com/28tb33fc
Reposted by Rahul Gupta
A project many years in the process, we’re pleased to present our work on multi-ancestry meta-analysis across a boatload of traits in the UK Biobank: www.nature.com/articles/s41...
Pan-UK Biobank genome-wide association analyses enhance discovery and resolution of ancestry-enriched effects - Nature Genetics
Genome-wide analyses for 7,266 traits leveraging data from several genetic ancestry groups in UK Biobank identify new associations and enhance resources for interpreting risk variants across diverse p...
www.nature.com
September 18, 2025 at 5:25 PM
A project many years in the process, we’re pleased to present our work on multi-ancestry meta-analysis across a boatload of traits in the UK Biobank: www.nature.com/articles/s41...
After years of chats, friends from my MD/PhD program and I launched a nerdy blog about science + medicine.
We explore everything from evolutionary theory to big data in science. @kaitavjeet.bsky.social just posted on the power of abstraction in biology 🧫
emergentpropertiesblog.com/2025/08/19/a...
We explore everything from evolutionary theory to big data in science. @kaitavjeet.bsky.social just posted on the power of abstraction in biology 🧫
emergentpropertiesblog.com/2025/08/19/a...
The case for abstraction in biology
One of the most challenging questions in all of biology is how to make sense of complex systems. This question is becoming increasingly relevant as advances in sequencing technologies decrease the cos...
emergentpropertiesblog.com
August 20, 2025 at 11:50 PM
After years of chats, friends from my MD/PhD program and I launched a nerdy blog about science + medicine.
We explore everything from evolutionary theory to big data in science. @kaitavjeet.bsky.social just posted on the power of abstraction in biology 🧫
emergentpropertiesblog.com/2025/08/19/a...
We explore everything from evolutionary theory to big data in science. @kaitavjeet.bsky.social just posted on the power of abstraction in biology 🧫
emergentpropertiesblog.com/2025/08/19/a...
Reposted by Rahul Gupta
Exciting preprint from @rahulg603.bsky.social and colleagues!
Mechanism of age-related accumulation of mitochondrial DNA mutations in human blood
www.biorxiv.org/content/10.1...
Mechanism of age-related accumulation of mitochondrial DNA mutations in human blood
www.biorxiv.org/content/10.1...
Mechanism of age-related accumulation of mitochondrial DNA mutations in human blood
One of the strongest signatures of aging is an accumulation of mutant mitochondrial DNA (mtDNA) heteroplasmy. Here we investigate the mechanism underlying this phenomenon by calling mtDNA sequence, ab...
www.biorxiv.org
May 30, 2025 at 8:45 AM
Exciting preprint from @rahulg603.bsky.social and colleagues!
Mechanism of age-related accumulation of mitochondrial DNA mutations in human blood
www.biorxiv.org/content/10.1...
Mechanism of age-related accumulation of mitochondrial DNA mutations in human blood
www.biorxiv.org/content/10.1...
Using population and statistical genetics across 750,000 people, we believe we have identified a putative mechanism for an important aging biomarker: the apparent age-related mtDNA mutation accrual in blood. Very excited this is up!
broad.io/7b3tuy
broad.io/7b3tuy
May 31, 2025 at 4:45 PM
Using population and statistical genetics across 750,000 people, we believe we have identified a putative mechanism for an important aging biomarker: the apparent age-related mtDNA mutation accrual in blood. Very excited this is up!
broad.io/7b3tuy
broad.io/7b3tuy
Reposted by Rahul Gupta
Type 1 diabetes (T1D) and other autoimmune diseases often co-occur in families. Leveraging data from 12.6K genotyped trios in @finngen.bsky.social, our work - online today in Cell Genomics - studied the transmission of parental autoimmune diseases on T1D in offspring.
www.cell.com/cell-genomic...
www.cell.com/cell-genomic...
Effects of parental autoimmune diseases on type 1 diabetes in offspring can be partially explained by HLA and non-HLA polymorphisms
Leveraging Finnish nationwide multi-generational registers and the biobanks of FinnGen,
Wang, Liu, et al. investigated the effect of parental autoimmune diseases on offspring
T1D. Their creative and r...
www.cell.com
April 25, 2025 at 8:40 PM
Type 1 diabetes (T1D) and other autoimmune diseases often co-occur in families. Leveraging data from 12.6K genotyped trios in @finngen.bsky.social, our work - online today in Cell Genomics - studied the transmission of parental autoimmune diseases on T1D in offspring.
www.cell.com/cell-genomic...
www.cell.com/cell-genomic...
Reposted by Rahul Gupta
Final_Version_of_Tarrifs_actualFINALcopy_version7_USETHISONE.docx
April 9, 2025 at 6:39 PM
Final_Version_of_Tarrifs_actualFINALcopy_version7_USETHISONE.docx
Reposted by Rahul Gupta
White House says no one will be fired over the Signal scandal because no one involved was trying to cure cancer.
March 24, 2025 at 9:54 PM
White House says no one will be fired over the Signal scandal because no one involved was trying to cure cancer.
Reposted by Rahul Gupta
There are days in life that shake you.
I’m shattered 💔 to share that I just found out that the US Government terminated my 2024 NIH Director’s Early Independence Award (~$2 million), threatening my long-promised assistant professor job at Columbia University
& academic career... 1/🧵
I’m shattered 💔 to share that I just found out that the US Government terminated my 2024 NIH Director’s Early Independence Award (~$2 million), threatening my long-promised assistant professor job at Columbia University
& academic career... 1/🧵
March 18, 2025 at 11:27 PM
There are days in life that shake you.
I’m shattered 💔 to share that I just found out that the US Government terminated my 2024 NIH Director’s Early Independence Award (~$2 million), threatening my long-promised assistant professor job at Columbia University
& academic career... 1/🧵
I’m shattered 💔 to share that I just found out that the US Government terminated my 2024 NIH Director’s Early Independence Award (~$2 million), threatening my long-promised assistant professor job at Columbia University
& academic career... 1/🧵
Reposted by Rahul Gupta
Here’s Elon cutting pediatric brain cancer research 👇🏻
This is horrible to post, but I may as well post it. We are essentially shutting down research operations in my group, which is focused on treatments for pediatric brain cancer. I’m a well funded investigator, and there’s no choice. Science can’t function without the stability of NIH
March 15, 2025 at 9:24 PM
Here’s Elon cutting pediatric brain cancer research 👇🏻
Reposted by Rahul Gupta
New preprint from the lab! 🚨
🧫 New galactose #CRISPR screening strategy
🎯 481 genes required for #OXPHOS
⚙️ #FAM136A in IMS proteostasis
👂Mito defects in #Menieres disease
by @marcellharhai.bsky.social @fbm-unil.bsky.social
A short thread 1/5
www.biorxiv.org/content/10.1...
🧫 New galactose #CRISPR screening strategy
🎯 481 genes required for #OXPHOS
⚙️ #FAM136A in IMS proteostasis
👂Mito defects in #Menieres disease
by @marcellharhai.bsky.social @fbm-unil.bsky.social
A short thread 1/5
www.biorxiv.org/content/10.1...
January 30, 2025 at 7:58 AM
New preprint from the lab! 🚨
🧫 New galactose #CRISPR screening strategy
🎯 481 genes required for #OXPHOS
⚙️ #FAM136A in IMS proteostasis
👂Mito defects in #Menieres disease
by @marcellharhai.bsky.social @fbm-unil.bsky.social
A short thread 1/5
www.biorxiv.org/content/10.1...
🧫 New galactose #CRISPR screening strategy
🎯 481 genes required for #OXPHOS
⚙️ #FAM136A in IMS proteostasis
👂Mito defects in #Menieres disease
by @marcellharhai.bsky.social @fbm-unil.bsky.social
A short thread 1/5
www.biorxiv.org/content/10.1...