Zack Williams, MD, PhD
@quantpsychiatry.bsky.social
•Autistic (+ADHD, OCD, Tourettes) autism researcher and trainee psychiatrist (rising PGY-1)
•YaleCSC➡️VanderbiltMSTP➡️UCLA
•Catatonia enthusiast, patient advocate, stats guy
•MH research/methods/advocacy, autism/neurodiversity, academic medicine, dumb jokes
•YaleCSC➡️VanderbiltMSTP➡️UCLA
•Catatonia enthusiast, patient advocate, stats guy
•MH research/methods/advocacy, autism/neurodiversity, academic medicine, dumb jokes
And even though the autistic sample is clearly not representative of the whole autistic population (they are much more depressed and suicidal than average, being selected from three studies that oversampled people for those topics), the descriptive clinical phenotype of that group *is* the paper.
March 20, 2025 at 3:31 AM
And even though the autistic sample is clearly not representative of the whole autistic population (they are much more depressed and suicidal than average, being selected from three studies that oversampled people for those topics), the descriptive clinical phenotype of that group *is* the paper.
Similar age trends were observed for some but not all of the C-SSRS items representing suicidal ideation severity, as well as the ordinal "level of ideation," as seen below. No meaningful sex differences were observed across the sample in any of these outcomes.
March 20, 2025 at 3:31 AM
Similar age trends were observed for some but not all of the C-SSRS items representing suicidal ideation severity, as well as the ordinal "level of ideation," as seen below. No meaningful sex differences were observed across the sample in any of these outcomes.
Below are the plots of (lifetime) suicidality and NSSI likelihood as a function of age in the sample. Both were quite common and had some complex/interesting age relationships that reflected both real clinical effects (like peaks in early adulthood) and recruitment biases (drop-offs later on)...
March 20, 2025 at 3:31 AM
Below are the plots of (lifetime) suicidality and NSSI likelihood as a function of age in the sample. Both were quite common and had some complex/interesting age relationships that reflected both real clinical effects (like peaks in early adulthood) and recruitment biases (drop-offs later on)...
To all of the #INSAR members voting in the upcoming board election, (not that anyone cares but) I'm officially endorsing my good (bluesky-less) friend and colleague Mirko Uljarević for INSAR treasurer! With quant skills like his, the society's money is in good hands.
February 1, 2025 at 6:40 AM
To all of the #INSAR members voting in the upcoming board election, (not that anyone cares but) I'm officially endorsing my good (bluesky-less) friend and colleague Mirko Uljarević for INSAR treasurer! With quant skills like his, the society's money is in good hands.
Fancy name tag for fancy government work!
December 9, 2024 at 3:35 PM
Fancy name tag for fancy government work!
The MitUK/MiA folks are so threatened by neurodiversity because it's a patient-driven movement wherein the labels of specific conditions get reified as peri-psychiatric identities despite depathologization. Because it's incompatible with "dropping the disorder," they just have to discredit it...
December 8, 2024 at 1:27 PM
The MitUK/MiA folks are so threatened by neurodiversity because it's a patient-driven movement wherein the labels of specific conditions get reified as peri-psychiatric identities despite depathologization. Because it's incompatible with "dropping the disorder," they just have to discredit it...
The real thing "to blame"...
December 8, 2024 at 1:02 PM
The real thing "to blame"...
![Picture of Judge Judy with [Judges Judily] as caption](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:a5xldz5xv3ywy62j7arsfzs2/bafkreieqaektqqqmwg4kipko5fg432k67erti3ppyxsjsjtshz5q2qylwq@jpeg)
Personally, I would love to exchange memes with my reviewers. The general peer review mood below:
December 2, 2024 at 3:42 PM
Personally, I would love to exchange memes with my reviewers. The general peer review mood below:
I really wish I could put reaction pictures in my responses to reviewers sometimes. This one especially would go to a few choice people...
December 2, 2024 at 3:13 PM
I really wish I could put reaction pictures in my responses to reviewers sometimes. This one especially would go to a few choice people...
Help, it's too early for this much cringe!
December 2, 2024 at 3:08 PM
Help, it's too early for this much cringe!
Sigh. Disappointed but not surprised.
December 1, 2024 at 2:24 PM
Sigh. Disappointed but not surprised.
Third year of our new Thanksgiving tradition - beef wellingtons! Who needs turkey anyways? Seven hours of cooking, but well worth it!
November 29, 2024 at 1:20 AM
Third year of our new Thanksgiving tradition - beef wellingtons! Who needs turkey anyways? Seven hours of cooking, but well worth it!
Watching the national dog show with the family, and clearly my boys want to heckle the competition and day how much cuter they are than the toy breed contestants (subtitles on because we can't hear shit otherwise).
November 28, 2024 at 6:44 PM
Watching the national dog show with the family, and clearly my boys want to heckle the competition and day how much cuter they are than the toy breed contestants (subtitles on because we can't hear shit otherwise).
Glad the comments are appreciated. I definitely don't want to come across as this guy (when adding my comments, which is often how I feel, lol)!
But that's probably just how I get treated by people on Twitter, and this platform is frankly a lot more charitable. 😀
But that's probably just how I get treated by people on Twitter, and this platform is frankly a lot more charitable. 😀
November 27, 2024 at 5:38 AM
Glad the comments are appreciated. I definitely don't want to come across as this guy (when adding my comments, which is often how I feel, lol)!
But that's probably just how I get treated by people on Twitter, and this platform is frankly a lot more charitable. 😀
But that's probably just how I get treated by people on Twitter, and this platform is frankly a lot more charitable. 😀
PSA: One of my favorite people (Heather Brown aka @thriving-w-autism.bsky.social has finally joined this lovely platform)!
Give her a follow if you're interested in autism/disability (self-)advocacy, higher education, mental health/well-being, participatory research, or that Canadian politeness!
Give her a follow if you're interested in autism/disability (self-)advocacy, higher education, mental health/well-being, participatory research, or that Canadian politeness!
November 26, 2024 at 4:47 PM
PSA: One of my favorite people (Heather Brown aka @thriving-w-autism.bsky.social has finally joined this lovely platform)!
Give her a follow if you're interested in autism/disability (self-)advocacy, higher education, mental health/well-being, participatory research, or that Canadian politeness!
Give her a follow if you're interested in autism/disability (self-)advocacy, higher education, mental health/well-being, participatory research, or that Canadian politeness!
This was the worst thing about living in CT. I actually had to decide how many layers to wear or I'd get effed up by mother nature. Being below the Mason-Dixon line is a bit kinder in that regard (and don't get me started on socal where I wore shorts all of 10th grade).
November 26, 2024 at 3:15 PM
This was the worst thing about living in CT. I actually had to decide how many layers to wear or I'd get effed up by mother nature. Being below the Mason-Dixon line is a bit kinder in that regard (and don't get me started on socal where I wore shorts all of 10th grade).
Awesome, will definitely check out the talk (and probably others too)!
Also, I hear you on the praise front (which is a shame - we scientists all try so hard to be "rigorous" we sometimes forget to congratulate each other on the wins too). Here's a great picture I shamelessly stole from my advisor!
Also, I hear you on the praise front (which is a shame - we scientists all try so hard to be "rigorous" we sometimes forget to congratulate each other on the wins too). Here's a great picture I shamelessly stole from my advisor!
November 25, 2024 at 8:37 PM
Awesome, will definitely check out the talk (and probably others too)!
Also, I hear you on the praise front (which is a shame - we scientists all try so hard to be "rigorous" we sometimes forget to congratulate each other on the wins too). Here's a great picture I shamelessly stole from my advisor!
Also, I hear you on the praise front (which is a shame - we scientists all try so hard to be "rigorous" we sometimes forget to congratulate each other on the wins too). Here's a great picture I shamelessly stole from my advisor!
Here's the clinical staging model and suggested interventions for each stage from the above paper. Medications are clearly the mainstay of psychosis treatment (because they have the highest level of evidence and work best), but most other interventions target behavioral/psychosocial factors. 2/
November 25, 2024 at 5:23 AM
Here's the clinical staging model and suggested interventions for each stage from the above paper. Medications are clearly the mainstay of psychosis treatment (because they have the highest level of evidence and work best), but most other interventions target behavioral/psychosocial factors. 2/
Me doing almost fuck-all to stop serious illness from occurring
November 24, 2024 at 11:36 PM
Me doing almost fuck-all to stop serious illness from occurring
And at least one reviewer still got on our ass about it not being a prereg'd study. Like come on people, I did what I could to make the study OS-compatible, and frankly this just turns into people making the perfect the enemy of the clearly pretty damn good.
November 24, 2024 at 8:12 PM
And at least one reviewer still got on our ass about it not being a prereg'd study. Like come on people, I did what I could to make the study OS-compatible, and frankly this just turns into people making the perfect the enemy of the clearly pretty damn good.
Tbh, could even be fixed by having the likes tied to the post version (like 55 likes[+13 on past edits]). But unimportant right now as there's like three hamsters on a wheel just keeping the server farm hosting bluesky from exploding.
[Pic: staff getting premium feature requests at a time like this]
[Pic: staff getting premium feature requests at a time like this]
November 24, 2024 at 7:40 PM
Tbh, could even be fixed by having the likes tied to the post version (like 55 likes[+13 on past edits]). But unimportant right now as there's like three hamsters on a wheel just keeping the server farm hosting bluesky from exploding.
[Pic: staff getting premium feature requests at a time like this]
[Pic: staff getting premium feature requests at a time like this]
I have to say that (as someone with ADHD that's medicated about as good as I can get it and still makes an unconscionable amount of typos), this will be me the second this platform begins to monetize by letting me buy premium features like post-hoc post editing...
November 24, 2024 at 7:10 PM
I have to say that (as someone with ADHD that's medicated about as good as I can get it and still makes an unconscionable amount of typos), this will be me the second this platform begins to monetize by letting me buy premium features like post-hoc post editing...