Chao Qi
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qcxy8886.bsky.social
Chao Qi
@qcxy8886.bsky.social
83 followers 160 following 5 posts
Assistant professor in the School of Basic Medical Sciences, Peking University
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Reposted by Chao Qi
tkatsinelos.bsky.social
I am delighted to share that our new manuscript is published as an online Pre-proof at the Journal of Biological Chemistry!! 🎉
www.jbc.org/article/S002...
Seeding biosensor cell line that reproduces the Alzheimer tau fold
The assembly of tau protein into amyloid filaments through templated seeding is believed to underlie the propagation of pathology in neurodegenerative diseases, such as Alzheimer’s disease (AD) and ot...
www.jbc.org
November 21, 2025 at 5:08 PM
Reposted by Chao Qi
sjorsscheres.bsky.social
We are looking for a computational postdoc to work with us on new optimisation algorithms to make #RELION even better. Join our bubbly team at the @mrclmb.bsky.social in Cambridge, UK. 🤗 RTs appreciated.

mrc.tal.net/vx/appcentre...
Quick Check Needed
mrc.tal.net
October 29, 2025 at 9:17 AM
Reposted by Chao Qi
sjorsscheres.bsky.social
Below (by @landerlab.bsky.social) is the 2nd #cryosparc recipe on @biorxivpreprint.bsky.social in a month. I remain worried about closed-source software affecting progress in #cryoEM. We should develop new algorithms instead!

#OpenSoftwareAcceleratesScience

www.biorxiv.org/content/10.1...
www.biorxiv.org
October 5, 2025 at 8:20 AM
qcxy8886.bsky.social
The best cover🥰, paired cats & paired helical filaments.
July 17, 2025 at 6:47 PM
Reposted by Chao Qi
sjorsscheres.bsky.social
Finally, the paper by @qcxy8886.bsky.social on #cryoEM of tau mutants V337M and R406W is out in NSMB (which is not the fastest journal). Tau filaments with these mutations have the same structures as in AD, which may be useful for the development of faster models.

www.nature.com/articles/s41...
Tau filaments with the Alzheimer fold in human MAPT mutants V337M and R406W - Nature Structural & Molecular Biology
Qi et al. used cryo-electron microscopy to determine the structures of tau filaments from the brains of individuals with MAPT mutants V337M and R406W, known to give rise to frontotemporal dementias. T...
www.nature.com
July 16, 2025 at 6:33 AM
Reposted by Chao Qi
sjorsscheres.bsky.social
At the #Synuclein2025 in Cambridge this week. There is a large unmet need for help with #cryoEM structure determination of amyloids.
April 10, 2025 at 5:22 PM
Reposted by Chao Qi
mrclmb.bsky.social
“If you’re really curious about science, then you should do it.”

We recently caught up with David Barford, Group Leader in the LMB’s Structural Studies Division, to learn more about his career, what inspires him and his group’s research into kinetochore complexes.

youtu.be/qaudt961iMU
From the scientist's view: a conversation with David Barford
YouTube video by MRC Laboratory of Molecular Biology
youtu.be
April 3, 2025 at 2:43 PM
Reposted by Chao Qi
sjorsscheres.bsky.social
I found the below in the stand of @stressmarq.bsky.social at #ADPD2025. When I asked how these "tau oligomers" were made, I was told this was a company secret! 😱😱😱
How can you ever publish results obtained with such materials? How could you or anyone else replicate them if the company went bust?
April 1, 2025 at 7:42 PM
Reposted by Chao Qi
sjorsscheres.bsky.social
Alzforum has written a piece on our most recent updates to the structure-based classification of tauopathies. 🥳
www.alzforum.org/news/researc...
Filling in the Family Tree—AD, CTE Folds Spotted in Other Tauopathies | ALZFORUM
www.alzforum.org
March 28, 2025 at 2:09 PM
qcxy8886.bsky.social
Happy to share our latest publication on
@naturesmb.bsky.social Natural Structure & Molecular Biology, we show tau filaments show Alzheimer fold in mutants V337M and R406W.
thanks @sjorsscheres.bsky.social and Michel Goedert's support. 🥳
rdcu.be/edqzW
rdcu.be/edoGv
Mutant tau filaments from some inherited frontotemporal dementias show the Alzheimer fold
Nature Structural & Molecular Biology - Frontotemporal dementias can be caused by mutations in MAPT, which encodes the protein tau; the mutant protein forms harmful aggregates in the brain....
rdcu.be
March 13, 2025 at 1:50 PM