Paul Thompson
@ptenigma.bsky.social
Neuroscientist, professor
AI guided tour - https://www.youtube.com/watch?v=fOORfzGjCTA
ENIGMA guided tour - https://www.youtube.com/watch?v=YNjP5nZsJyQ
Diffusion MRI of Brain Diseases - https://www.youtube.com/watch?v=i2jHFm0wcN0
AI guided tour - https://www.youtube.com/watch?v=fOORfzGjCTA
ENIGMA guided tour - https://www.youtube.com/watch?v=YNjP5nZsJyQ
Diffusion MRI of Brain Diseases - https://www.youtube.com/watch?v=i2jHFm0wcN0
It kind of works and is strangely pleasing !
*But my daughter said "I am not sure how this helps me to arrange the lights" :)
*But my daughter said "I am not sure how this helps me to arrange the lights" :)
November 23, 2025 at 2:13 AM
It kind of works and is strangely pleasing !
*But my daughter said "I am not sure how this helps me to arrange the lights" :)
*But my daughter said "I am not sure how this helps me to arrange the lights" :)
🔥 OK just for fun, here's a holiday puzzle for you.... 🔥
"How to Light a Tree with Stein Variational Gradient Descent"
aiandthebrain.substack.com/p/how-to-lig...
"How to Light a Tree with Stein Variational Gradient Descent"
aiandthebrain.substack.com/p/how-to-lig...
How to Light a Tree with Stein Variational Gradient Descent
My daughter said the lights on the Christmas tree were not very uniform, leading to an interesting puzzle....
aiandthebrain.substack.com
November 23, 2025 at 1:39 AM
🔥 OK just for fun, here's a holiday puzzle for you.... 🔥
"How to Light a Tree with Stein Variational Gradient Descent"
aiandthebrain.substack.com/p/how-to-lig...
"How to Light a Tree with Stein Variational Gradient Descent"
aiandthebrain.substack.com/p/how-to-lig...
🔥You will see in general that brains, societies of humans, and AI are all networks, and the best synergies of all 3, or of 2 of them, involve networks with mutual feedback
🔥For example, AI is being improved by humans iteratively improving it, not just by backpropagation 👇
🔥For example, AI is being improved by humans iteratively improving it, not just by backpropagation 👇
An intriguing interview [1] with my fellow Yorkshireman+inimitable brain mapper Dr Karl Friston on the free energy principle +social networks*
*you will often see a modular hierarchical organisation emerging in human consortia to rapidly communicate information via dual graphs as we noted in [2]
*you will often see a modular hierarchical organisation emerging in human consortia to rapidly communicate information via dual graphs as we noted in [2]
November 21, 2025 at 6:30 AM
🔥You will see in general that brains, societies of humans, and AI are all networks, and the best synergies of all 3, or of 2 of them, involve networks with mutual feedback
🔥For example, AI is being improved by humans iteratively improving it, not just by backpropagation 👇
🔥For example, AI is being improved by humans iteratively improving it, not just by backpropagation 👇
An intriguing interview [1] with my fellow Yorkshireman+inimitable brain mapper Dr Karl Friston on the free energy principle +social networks*
*you will often see a modular hierarchical organisation emerging in human consortia to rapidly communicate information via dual graphs as we noted in [2]
*you will often see a modular hierarchical organisation emerging in human consortia to rapidly communicate information via dual graphs as we noted in [2]
November 21, 2025 at 6:17 AM
An intriguing interview [1] with my fellow Yorkshireman+inimitable brain mapper Dr Karl Friston on the free energy principle +social networks*
*you will often see a modular hierarchical organisation emerging in human consortia to rapidly communicate information via dual graphs as we noted in [2]
*you will often see a modular hierarchical organisation emerging in human consortia to rapidly communicate information via dual graphs as we noted in [2]
🔥 Brilliant guided tour from the ORIGAMI Lab showing how they are bringing Nipoppy and Neurobagel infrastructure to ENIGMA-Parkinson’s to power large-scale multisite data integration 🔥
PAPER: apertureneuro.org/article/1450...
PAPER: apertureneuro.org/article/1450...
November 19, 2025 at 3:25 AM
🔥 Brilliant guided tour from the ORIGAMI Lab showing how they are bringing Nipoppy and Neurobagel infrastructure to ENIGMA-Parkinson’s to power large-scale multisite data integration 🔥
PAPER: apertureneuro.org/article/1450...
PAPER: apertureneuro.org/article/1450...
Looking forward to teaching our #USC neuroscience PhD students tomorrow, 32 years after starting as a nervous new student who knew 0 neuroscience :) Fortunately the main textbook now weighs 9 pounds - 3.5 times heavier than in 1993 !!
@USCNGP
@USCNGP
November 18, 2025 at 2:49 AM
Looking forward to teaching our #USC neuroscience PhD students tomorrow, 32 years after starting as a nervous new student who knew 0 neuroscience :) Fortunately the main textbook now weighs 9 pounds - 3.5 times heavier than in 1993 !!
@USCNGP
@USCNGP
🔥 DOES SCHIZOPHRENIA have SUBTYPES? What about other brain disorders?
🔥 Brilliant new paper www.nature.com/articles/s41... by @alisaffet.bsky.social +Cemre Candemir of the SoCaT lab (pictured) explains how 'biotypes' are defined, + why
🔥 Explained more in this VIDEO: www.youtube.com/watch?v=nPH-...
🔥 Brilliant new paper www.nature.com/articles/s41... by @alisaffet.bsky.social +Cemre Candemir of the SoCaT lab (pictured) explains how 'biotypes' are defined, + why
🔥 Explained more in this VIDEO: www.youtube.com/watch?v=nPH-...
November 18, 2025 at 2:36 AM
🔥 DOES SCHIZOPHRENIA have SUBTYPES? What about other brain disorders?
🔥 Brilliant new paper www.nature.com/articles/s41... by @alisaffet.bsky.social +Cemre Candemir of the SoCaT lab (pictured) explains how 'biotypes' are defined, + why
🔥 Explained more in this VIDEO: www.youtube.com/watch?v=nPH-...
🔥 Brilliant new paper www.nature.com/articles/s41... by @alisaffet.bsky.social +Cemre Candemir of the SoCaT lab (pictured) explains how 'biotypes' are defined, + why
🔥 Explained more in this VIDEO: www.youtube.com/watch?v=nPH-...
Reposted by Paul Thompson
The plane turned left in the end :)
November 16, 2025 at 4:52 AM
The plane turned left in the end :)
🔥 Global AI-Brain Initiative (AI and the Brain)
aiandthebrain.substack.com/p/global-ai-...
(a post for our new students; some links in it may be more widely interesting!)
aiandthebrain.substack.com/p/global-ai-...
(a post for our new students; some links in it may be more widely interesting!)
Global AI-Brain Initiative (AI and the Brain)
The Global AI-Brain Initiative is an international research program led by mathematician and neuroscientist Paul M.
aiandthebrain.substack.com
November 16, 2025 at 12:26 AM
🔥 Global AI-Brain Initiative (AI and the Brain)
aiandthebrain.substack.com/p/global-ai-...
(a post for our new students; some links in it may be more widely interesting!)
aiandthebrain.substack.com/p/global-ai-...
(a post for our new students; some links in it may be more widely interesting!)
from now on I am going to begin all papers with "Any serious consideration..."
November 15, 2025 at 4:24 AM
from now on I am going to begin all papers with "Any serious consideration..."
Pilot seems to have gone the wrong way*
*I hope they turn left at the North Pole
*I hope they turn left at the North Pole
November 15, 2025 at 4:03 AM
Pilot seems to have gone the wrong way*
*I hope they turn left at the North Pole
*I hope they turn left at the North Pole
Quick escape from airport during layover
November 15, 2025 at 3:45 AM
Quick escape from airport during layover
Sad to leave India
November 15, 2025 at 3:24 AM
Sad to leave India
Should neuroscientists and clinical scientists study psychedelics ?
November 15, 2025 at 3:07 AM
Should neuroscientists and clinical scientists study psychedelics ?
How does ketamine work as an antidepressant ?
*explanation by award-winning neuroscientist Prof Vidita Vaidhya (TIFR Mumbai)
*explanation by award-winning neuroscientist Prof Vidita Vaidhya (TIFR Mumbai)
November 15, 2025 at 2:59 AM
How does ketamine work as an antidepressant ?
*explanation by award-winning neuroscientist Prof Vidita Vaidhya (TIFR Mumbai)
*explanation by award-winning neuroscientist Prof Vidita Vaidhya (TIFR Mumbai)
🔥 Thank you Drs. Raghu Padinjat, Biju Viswanath, and the NCBS Rohini Nilekani Centre for Brain & Mind for inviting me to speak at their neuroscience symposium at the Manotsava Mental Health Festival - an inspiring meeting with >6,000 attendees advancing science, awareness, +reducing stigma.
🧠
🧠
November 15, 2025 at 2:27 AM
🔥 Thank you Drs. Raghu Padinjat, Biju Viswanath, and the NCBS Rohini Nilekani Centre for Brain & Mind for inviting me to speak at their neuroscience symposium at the Manotsava Mental Health Festival - an inspiring meeting with >6,000 attendees advancing science, awareness, +reducing stigma.
🧠
🧠
Langevin SDE simulation (solution below)
November 13, 2025 at 12:29 PM
Langevin SDE simulation (solution below)
Thank you Dr Shriya Palchaudhuri for having me as a guest on the NCBS* Podcast !
* NCBS is a large technical center in India that focuses on fundamental research in biology and neuroscience including biochemistry, biophysics, bioinformatics, neurobiology, cellular signalling, genetics +development
* NCBS is a large technical center in India that focuses on fundamental research in biology and neuroscience including biochemistry, biophysics, bioinformatics, neurobiology, cellular signalling, genetics +development
November 13, 2025 at 9:24 AM
Thank you Dr Shriya Palchaudhuri for having me as a guest on the NCBS* Podcast !
* NCBS is a large technical center in India that focuses on fundamental research in biology and neuroscience including biochemistry, biophysics, bioinformatics, neurobiology, cellular signalling, genetics +development
* NCBS is a large technical center in India that focuses on fundamental research in biology and neuroscience including biochemistry, biophysics, bioinformatics, neurobiology, cellular signalling, genetics +development
Very impressive work by the India ENIGMA Initiative team at NIMHANS, Bangalore, who have deeply assessed 200 elderly people w Alzheimer’s, MCI and healthy aging with multimodal MRI, genomics, multi-omics assays, actigraphy, SEDOH, diet, access to healthcare to understand factors influencing dementia
November 13, 2025 at 9:04 AM
Very impressive work by the India ENIGMA Initiative team at NIMHANS, Bangalore, who have deeply assessed 200 elderly people w Alzheimer’s, MCI and healthy aging with multimodal MRI, genomics, multi-omics assays, actigraphy, SEDOH, diet, access to healthcare to understand factors influencing dementia