ProfMakris
@profmakris.bsky.social
Emeritus Professor of Haemostasis and Thrombosis in Sheffield, UK. I tweet about thrombosis, hemophilia, COVID-19, medicine, NHS & AI. Opinions are my own.
Recombinant ADAMTS13 should be the standard of care for patients with congenital TTP. FFP is an inferior product both in terms of efficacy and safety.
A paper in the journal Blood describes the experience from Japan in 14 patients.
lnkd.in/eXg345SD
A paper in the journal Blood describes the experience from Japan in 14 patients.
lnkd.in/eXg345SD
May 15, 2025 at 6:07 PM
Recombinant ADAMTS13 should be the standard of care for patients with congenital TTP. FFP is an inferior product both in terms of efficacy and safety.
A paper in the journal Blood describes the experience from Japan in 14 patients.
lnkd.in/eXg345SD
A paper in the journal Blood describes the experience from Japan in 14 patients.
lnkd.in/eXg345SD
For anybody interested in birds, this is a great book. The author tried to learn more about birds by building a shed/hide close to his home in the south of England. Very well researched and informative. I learnt a lot about the birds we encounter in the UK.
May 14, 2025 at 11:32 AM
For anybody interested in birds, this is a great book. The author tried to learn more about birds by building a shed/hide close to his home in the south of England. Very well researched and informative. I learnt a lot about the birds we encounter in the UK.
If you are interested in birds, the Greek island of Lesbos is a great place to visit this time of the year, as it coincides with the spring migration. We saw 170 species of bird in one week thanks to the skills of "Mr Lesbos Birding" Howard Vaughan, who also took the bird pictures below.
May 7, 2025 at 2:37 PM
If you are interested in birds, the Greek island of Lesbos is a great place to visit this time of the year, as it coincides with the spring migration. We saw 170 species of bird in one week thanks to the skills of "Mr Lesbos Birding" Howard Vaughan, who also took the bird pictures below.
My commentary on PITT (PF4-associated immune thrombocytopenia and thrombosis) has just been published in the British Journal of Haematology. This group of disorders is more than HIT and VITT and we should be looking for it more widely. onlinelibrary.wiley.com/doi/10.1111/...
May 5, 2025 at 6:00 AM
My commentary on PITT (PF4-associated immune thrombocytopenia and thrombosis) has just been published in the British Journal of Haematology. This group of disorders is more than HIT and VITT and we should be looking for it more widely. onlinelibrary.wiley.com/doi/10.1111/...
Our editorial on the Paradox of Choice in Hemophilia has just been published in the journal Research and Practice in Thrombosis and Haemostasis. Like all papers in this journal, it is freely available. tinyurl.com/4kw9hcth @rpth.bsky.social #hemophilia #haemophilia
April 21, 2025 at 10:42 AM
Our editorial on the Paradox of Choice in Hemophilia has just been published in the journal Research and Practice in Thrombosis and Haemostasis. Like all papers in this journal, it is freely available. tinyurl.com/4kw9hcth @rpth.bsky.social #hemophilia #haemophilia
A paper in @NEJM describes 14 patients with #hemophilia B who had the Pfizer gene therapy. Their achieved FIX levels remained stable over a median of 5.5 years. Confirmation that durability following hemophilia B gene therapy is very different to that in hemophilia A. tinyurl.com/2b2zzc37
April 18, 2025 at 8:58 AM
A paper in @NEJM describes 14 patients with #hemophilia B who had the Pfizer gene therapy. Their achieved FIX levels remained stable over a median of 5.5 years. Confirmation that durability following hemophilia B gene therapy is very different to that in hemophilia A. tinyurl.com/2b2zzc37
An article in the current issue of @nejm.org discusses the impact of the US foreign assistance cuts on global health. Some of the impacts are not readily obvious. The authors advocate reforming the foreign assistance program rather than dismantling it.
April 18, 2025 at 8:47 AM
An article in the current issue of @nejm.org discusses the impact of the US foreign assistance cuts on global health. Some of the impacts are not readily obvious. The authors advocate reforming the foreign assistance program rather than dismantling it.
The BIC meeting in Italy is always a great meeting, showcasing the latest science and with plenty of time for discussion. Remember the deadline for abstract submission is the 30th April 2025. #hemophilia #VWD #TMA #TTP
April 18, 2025 at 8:05 AM
The BIC meeting in Italy is always a great meeting, showcasing the latest science and with plenty of time for discussion. Remember the deadline for abstract submission is the 30th April 2025. #hemophilia #VWD #TMA #TTP
Today is #WorldHemophiliaDay and this year's theme is that women and girls bleed too. Despite the development of brilliant treatments to treat severe #hemophilia primarily in men, the diagnosis and treatment of women have not received as much attention.
April 17, 2025 at 7:59 AM
Today is #WorldHemophiliaDay and this year's theme is that women and girls bleed too. Despite the development of brilliant treatments to treat severe #hemophilia primarily in men, the diagnosis and treatment of women have not received as much attention.
Thank you for the copies of the paper on the UK Infected Blood Inquiry that was published in @BloodJournal. It is interesting to see the section on lessons learned. Despite the @bloodinquiry, the UK continues to use cryo and FFP without viral inactivation. #hemophilia
April 10, 2025 at 8:15 PM
Thank you for the copies of the paper on the UK Infected Blood Inquiry that was published in @BloodJournal. It is interesting to see the section on lessons learned. Despite the @bloodinquiry, the UK continues to use cryo and FFP without viral inactivation. #hemophilia
Article on Generative AI in medicine published today in @nejm.org. It discusses the potential uses and risks. One issue you can be sure of, is that AI will be embedded in the everyday practice of medicine in the very near future, even more than today. tinyurl.com/4sbjpjvs
April 10, 2025 at 4:40 PM
Article on Generative AI in medicine published today in @nejm.org. It discusses the potential uses and risks. One issue you can be sure of, is that AI will be embedded in the everyday practice of medicine in the very near future, even more than today. tinyurl.com/4sbjpjvs
If you are a scientist who is not using AI yet, this article from today's @nature.com journal will be of great help. Whether we like it or not, AI will be everywhere very soon, just like the internet.
April 8, 2025 at 8:36 PM
If you are a scientist who is not using AI yet, this article from today's @nature.com journal will be of great help. Whether we like it or not, AI will be everywhere very soon, just like the internet.
Everybody has an opinion about racism, but as the author of this book explains, the plural of anecdote is not data. This is a serious book looking at the scientific evidence around racism. It will not come as a surprise to read that racism is still in everything.
April 6, 2025 at 11:39 AM
Everybody has an opinion about racism, but as the author of this book explains, the plural of anecdote is not data. This is a serious book looking at the scientific evidence around racism. It will not come as a surprise to read that racism is still in everything.
Vaccination skeptics should have a look at this figure. It shows the impact of the introduction of RSV vaccination for patients aged 75-80 on hospital admissions in the UK. tinyurl.com/5d48u7mm
April 4, 2025 at 1:20 PM
Vaccination skeptics should have a look at this figure. It shows the impact of the introduction of RSV vaccination for patients aged 75-80 on hospital admissions in the UK. tinyurl.com/5d48u7mm
Important paper: In patients with cancer and venous thrombosis, extended anticoagulation with low dose Apixaban is as good as full dose Apixaban in preventing thrombosis recurrence and is associated with less bleeding. tinyurl.com/yyfuan35
April 3, 2025 at 8:57 PM
Important paper: In patients with cancer and venous thrombosis, extended anticoagulation with low dose Apixaban is as good as full dose Apixaban in preventing thrombosis recurrence and is associated with less bleeding. tinyurl.com/yyfuan35
Professor Christine Lee reflects on some of the conclusions of the UK Infected Blood Inquiry. The manuscript has just been published by the journal Haemophilia. @haemophilia_jnl #hemophilia. The PDF of the manuscript is freely available at: tinyurl.com/mvh2mk22
April 3, 2025 at 8:32 PM
Professor Christine Lee reflects on some of the conclusions of the UK Infected Blood Inquiry. The manuscript has just been published by the journal Haemophilia. @haemophilia_jnl #hemophilia. The PDF of the manuscript is freely available at: tinyurl.com/mvh2mk22
Our paper on inhibitor trends is now published in the journal Haemophilia. The number of inhibitors in previously untreated patients has markedly reduced, but it is possible that this is due to delayed exposure to FVIII. tinyurl.com/2mr3t5e3
April 3, 2025 at 7:21 PM
Our paper on inhibitor trends is now published in the journal Haemophilia. The number of inhibitors in previously untreated patients has markedly reduced, but it is possible that this is due to delayed exposure to FVIII. tinyurl.com/2mr3t5e3
Comprehensive review of gene therapy in #hemophilia accepted for publication by Molecular Therapy. The pre-proof is on line at tinyurl.com/3sb4nuex
March 31, 2025 at 8:54 PM
Comprehensive review of gene therapy in #hemophilia accepted for publication by Molecular Therapy. The pre-proof is on line at tinyurl.com/3sb4nuex
Incredible: dropbox.com/scl/fi/qy2ja.... This podcast was produced 100% by AI. It is entirely based on the editorial by myself and Brian O'Mahony published in @rpth.bsky.social. It is 21 min and remarkably accurate. Thank you, Eugene Fan, for showing me what is possible.
March 30, 2025 at 4:54 PM
Incredible: dropbox.com/scl/fi/qy2ja.... This podcast was produced 100% by AI. It is entirely based on the editorial by myself and Brian O'Mahony published in @rpth.bsky.social. It is 21 min and remarkably accurate. Thank you, Eugene Fan, for showing me what is possible.
This is an amazingly prophetic book written by two Harvard professors who teach political science. Although published in 2018, it clearly describes what is happening in the world and the US in particular today. "History does not repeat itself; it rhymes."
March 30, 2025 at 8:05 AM
This is an amazingly prophetic book written by two Harvard professors who teach political science. Although published in 2018, it clearly describes what is happening in the world and the US in particular today. "History does not repeat itself; it rhymes."
If you are still unsure whether to ask for your data to be deleted by 23andMe and any retained samples destroyed, have a read of this article in the New England Journal of Medicine @nejm.org.
March 27, 2025 at 1:11 PM
If you are still unsure whether to ask for your data to be deleted by 23andMe and any retained samples destroyed, have a read of this article in the New England Journal of Medicine @nejm.org.
Our editorial on #hemophilia treatments and the paradox of choice is now available in the journal Research and Practice in Thrombosis and Haemostasis. www.rpthjournal.org/article/S247...
March 26, 2025 at 9:09 PM
Our editorial on #hemophilia treatments and the paradox of choice is now available in the journal Research and Practice in Thrombosis and Haemostasis. www.rpthjournal.org/article/S247...
Von Willebrand disease associated angiodysplasia can be challenging to manage. I suspect the best treatment will be targeting angiogenesis rather than VWD. Excellent review on the subject in Haematologica. tinyurl.com/vu7n9w5h
March 26, 2025 at 7:56 PM
Von Willebrand disease associated angiodysplasia can be challenging to manage. I suspect the best treatment will be targeting angiogenesis rather than VWD. Excellent review on the subject in Haematologica. tinyurl.com/vu7n9w5h
I bought this book when META/Facebook (who claim to believe in free speech) got a Gag order to stop the author promoting the book! The author was a senior employee at Facebook, and this is her memoir. What she writes about Facebook will shock all readers because the results impact everybody.
March 23, 2025 at 7:55 PM
I bought this book when META/Facebook (who claim to believe in free speech) got a Gag order to stop the author promoting the book! The author was a senior employee at Facebook, and this is her memoir. What she writes about Facebook will shock all readers because the results impact everybody.
The new dosing method for Fitusiran appears to provide equal efficacy without thrombotic events. The number of patients, however, is very small. Safety will only be demonstrated with real world data on a much larger number of patients. tinyurl.com/mupbhanr
March 12, 2025 at 9:10 PM
The new dosing method for Fitusiran appears to provide equal efficacy without thrombotic events. The number of patients, however, is very small. Safety will only be demonstrated with real world data on a much larger number of patients. tinyurl.com/mupbhanr