PreOperative Performance
@preoperative.bsky.social
Anisotropic diffusion phantom technology
Neuroimaging reference standards for MRI,
data harmonisation solutions for CNS trials, imaging biomarker studies 🧠
✉️ [email protected]
Neuroimaging reference standards for MRI,
data harmonisation solutions for CNS trials, imaging biomarker studies 🧠
✉️ [email protected]
This is how anisotropic diffusion phantom reference standards add real value - turning subtle, hard-to-spot inconsistencies into clear, actionable information, ensuring that downstream analysis and clinical decisions are based on trustworthy data.
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December 11, 2025 at 12:08 PM
This is how anisotropic diffusion phantom reference standards add real value - turning subtle, hard-to-spot inconsistencies into clear, actionable information, ensuring that downstream analysis and clinical decisions are based on trustworthy data.
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In our white-matter modules, any L-R orientation mismatch between the image and the b-vectors becomes immediately visible, the diffusion signal falls perpendicular to the fiber bundle axes on both diagonal bundles.
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December 11, 2025 at 12:08 PM
In our white-matter modules, any L-R orientation mismatch between the image and the b-vectors becomes immediately visible, the diffusion signal falls perpendicular to the fiber bundle axes on both diagonal bundles.
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PreOperative Performance’s ground-truth phantoms with white matter simulating modules enable a capability that can be missed in routine practice - clear, objective detection of orientation mismatches and diffusion encoding errors.
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December 11, 2025 at 12:08 PM
PreOperative Performance’s ground-truth phantoms with white matter simulating modules enable a capability that can be missed in routine practice - clear, objective detection of orientation mismatches and diffusion encoding errors.
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Neurological reference standards can solve non-obvious and costly problems in neuroimaging data quality.
A short thread…
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#MRI #dMRI #diffusionMRI #neurosky #neuro #neurorad #neuroradiology #neuroscience #imagingstudies #radiologyAI
A short thread…
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#MRI #dMRI #diffusionMRI #neurosky #neuro #neurorad #neuroradiology #neuroscience #imagingstudies #radiologyAI
December 11, 2025 at 12:08 PM
Neurological reference standards can solve non-obvious and costly problems in neuroimaging data quality.
A short thread…
(1/6)
#MRI #dMRI #diffusionMRI #neurosky #neuro #neurorad #neuroradiology #neuroscience #imagingstudies #radiologyAI
A short thread…
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#MRI #dMRI #diffusionMRI #neurosky #neuro #neurorad #neuroradiology #neuroscience #imagingstudies #radiologyAI
This demonstrates that the modules behave as a stable reference, useful for multi-site MRI data comparisons, longitudinal QA & validating AI tools that depend on diffusion metrics.
This is one of the building blocks for quality controlled standards in diffusion MRI across sites and vendors.
6/6
This is one of the building blocks for quality controlled standards in diffusion MRI across sites and vendors.
6/6
November 28, 2025 at 4:30 PM
This demonstrates that the modules behave as a stable reference, useful for multi-site MRI data comparisons, longitudinal QA & validating AI tools that depend on diffusion metrics.
This is one of the building blocks for quality controlled standards in diffusion MRI across sites and vendors.
6/6
This is one of the building blocks for quality controlled standards in diffusion MRI across sites and vendors.
6/6
Whisker plots of FA values in the bundle bins for two versions of the same phantom:
▶️ outliers above,
▶️ box spans 25th-75th percentile, whiskers show range of values,
▶️ yellow lines show median
and,
▶️ profiles of average FA values along the bundle for both phantom versions.
4/6
▶️ outliers above,
▶️ box spans 25th-75th percentile, whiskers show range of values,
▶️ yellow lines show median
and,
▶️ profiles of average FA values along the bundle for both phantom versions.
4/6
November 28, 2025 at 4:30 PM
Whisker plots of FA values in the bundle bins for two versions of the same phantom:
▶️ outliers above,
▶️ box spans 25th-75th percentile, whiskers show range of values,
▶️ yellow lines show median
and,
▶️ profiles of average FA values along the bundle for both phantom versions.
4/6
▶️ outliers above,
▶️ box spans 25th-75th percentile, whiskers show range of values,
▶️ yellow lines show median
and,
▶️ profiles of average FA values along the bundle for both phantom versions.
4/6
Here's what you're seeing in the images -
Our phantom’s 90° crossing fiber module with segmented mask overlaid on the large bundle (in AP direction), and a sagittal view of the same bundle and overlay, and…
3/6
Our phantom’s 90° crossing fiber module with segmented mask overlaid on the large bundle (in AP direction), and a sagittal view of the same bundle and overlay, and…
3/6
November 28, 2025 at 4:30 PM
Here's what you're seeing in the images -
Our phantom’s 90° crossing fiber module with segmented mask overlaid on the large bundle (in AP direction), and a sagittal view of the same bundle and overlay, and…
3/6
Our phantom’s 90° crossing fiber module with segmented mask overlaid on the large bundle (in AP direction), and a sagittal view of the same bundle and overlay, and…
3/6
Diffusion MRI is sensitive to scanner and protocol differences which is why multi-site trials, studies and AI tools struggle with trust in the numbers.
This thread introduces a phantom MRI data analysis tool, in use with our phantom technology, measuring the reproducibility of phantom data.
1/6
This thread introduces a phantom MRI data analysis tool, in use with our phantom technology, measuring the reproducibility of phantom data.
1/6
November 28, 2025 at 4:30 PM
Diffusion MRI is sensitive to scanner and protocol differences which is why multi-site trials, studies and AI tools struggle with trust in the numbers.
This thread introduces a phantom MRI data analysis tool, in use with our phantom technology, measuring the reproducibility of phantom data.
1/6
This thread introduces a phantom MRI data analysis tool, in use with our phantom technology, measuring the reproducibility of phantom data.
1/6
Sharing work presented at the @esmrmb.bsky.social meeting in Marseille earlier this month, demonstrating our anisotropic diffusion phantom’s utility with higher-order tensor diffusion data models.
#Neuroscience #neuro #diffusionMRI #mri #dki #ESMRMB2025
#Neuroscience #neuro #diffusionMRI #mri #dki #ESMRMB2025
October 20, 2025 at 8:04 PM
Sharing work presented at the @esmrmb.bsky.social meeting in Marseille earlier this month, demonstrating our anisotropic diffusion phantom’s utility with higher-order tensor diffusion data models.
#Neuroscience #neuro #diffusionMRI #mri #dki #ESMRMB2025
#Neuroscience #neuro #diffusionMRI #mri #dki #ESMRMB2025
PreOperative Performance is delighted to attend the International Society of Tractography meeting in Bordeaux this week!
Say hello, DM or email
✉️: [email protected]
@tractography.bsky.social
Say hello, DM or email
✉️: [email protected]
@tractography.bsky.social
October 14, 2025 at 12:56 PM
PreOperative Performance is delighted to attend the International Society of Tractography meeting in Bordeaux this week!
Say hello, DM or email
✉️: [email protected]
@tractography.bsky.social
Say hello, DM or email
✉️: [email protected]
@tractography.bsky.social
Some last scenes from near Marseille’s Vieux Port. Marseille was founded ~ 600BCE by Phoenician sailors and despite modern infrastructure requirements has wonderfully preserved layers of history.
October 12, 2025 at 9:02 AM
Some last scenes from near Marseille’s Vieux Port. Marseille was founded ~ 600BCE by Phoenician sailors and despite modern infrastructure requirements has wonderfully preserved layers of history.
Thank you @esmrmb.bsky.social and thank you Marseille!
This was a greatly enjoyable meeting and I was delighted to see sessions dedicated to the importance of medical imaging quality (control & assurance) and reference standards.
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This was a greatly enjoyable meeting and I was delighted to see sessions dedicated to the importance of medical imaging quality (control & assurance) and reference standards.
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October 12, 2025 at 9:00 AM
Thank you @esmrmb.bsky.social and thank you Marseille!
This was a greatly enjoyable meeting and I was delighted to see sessions dedicated to the importance of medical imaging quality (control & assurance) and reference standards.
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This was a greatly enjoyable meeting and I was delighted to see sessions dedicated to the importance of medical imaging quality (control & assurance) and reference standards.
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Day 3 of #ESMRMB2025 begins shortly. It’s poster day!
In poster PG353 PreOperative Performance’s technology is applied to higher order tensor models of diffusion MRI data which can resolve complex neural architecture such as areas with crossing fibers.
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In poster PG353 PreOperative Performance’s technology is applied to higher order tensor models of diffusion MRI data which can resolve complex neural architecture such as areas with crossing fibers.
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October 10, 2025 at 8:21 AM
Day 3 of #ESMRMB2025 begins shortly. It’s poster day!
In poster PG353 PreOperative Performance’s technology is applied to higher order tensor models of diffusion MRI data which can resolve complex neural architecture such as areas with crossing fibers.
(1/3)
In poster PG353 PreOperative Performance’s technology is applied to higher order tensor models of diffusion MRI data which can resolve complex neural architecture such as areas with crossing fibers.
(1/3)
Preclinical imaging, including studies of ex-vivo tissue and organoid models, play a critical role in advancing MR imaging research by providing the means to explore the biological underpinnings of disease, refine imaging techniques and uncover insights…
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October 6, 2025 at 8:15 PM
Preclinical imaging, including studies of ex-vivo tissue and organoid models, play a critical role in advancing MR imaging research by providing the means to explore the biological underpinnings of disease, refine imaging techniques and uncover insights…
🧵1/n
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We’re looking forward to attending #ESMRMB 2025 from October 8-11th
🧠
We look forward to meeting old friends and new and engaging in discussions about our anisotropic diffusion phantom technology. We are delighted to share that our technology will feature in the scientific program.
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🧠
We look forward to meeting old friends and new and engaging in discussions about our anisotropic diffusion phantom technology. We are delighted to share that our technology will feature in the scientific program.
1/2
September 29, 2025 at 3:54 PM
We’re looking forward to attending #ESMRMB 2025 from October 8-11th
🧠
We look forward to meeting old friends and new and engaging in discussions about our anisotropic diffusion phantom technology. We are delighted to share that our technology will feature in the scientific program.
1/2
🧠
We look forward to meeting old friends and new and engaging in discussions about our anisotropic diffusion phantom technology. We are delighted to share that our technology will feature in the scientific program.
1/2
Through use of PreOperative Performance’s phantom technology, we can explain tractography performance and determine the resolvability of tracts that can be achieved given their sizes, specific to the MR system and protocol used.
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August 25, 2025 at 1:47 PM
Through use of PreOperative Performance’s phantom technology, we can explain tractography performance and determine the resolvability of tracts that can be achieved given their sizes, specific to the MR system and protocol used.
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The 3T data quality and protocol resulted in well-defined tracts (all 6 with 3 varying diameters ) when seed-based probabilistic tractography was performed. Multiple seeds were only required for the thinner bundles.
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August 25, 2025 at 1:47 PM
The 3T data quality and protocol resulted in well-defined tracts (all 6 with 3 varying diameters ) when seed-based probabilistic tractography was performed. Multiple seeds were only required for the thinner bundles.
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In this diagram we show a comparison of results for fitting the tensor model to data collected at 2 field strengths and the resulting tractography.
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August 25, 2025 at 1:47 PM
In this diagram we show a comparison of results for fitting the tensor model to data collected at 2 field strengths and the resulting tractography.
3/8
3/8
Imaging at 1.5T is not without its advantages, there are less distortions at lower field and some patients with implanted medical devices (such as cochlear implants) may be conditionally scanned at 1.5T and not at higher field strengths.
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August 25, 2025 at 1:47 PM
Imaging at 1.5T is not without its advantages, there are less distortions at lower field and some patients with implanted medical devices (such as cochlear implants) may be conditionally scanned at 1.5T and not at higher field strengths.
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MR imaging at 1.5T vs 3T have different advantages. 🧠
Aside from cost considerations, imaging at 3T delivers higher signal to noise (SNR) enabling increased spatial resolution, critical for identification of smaller white matter tracts and changes that may result from injury or disease.
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Aside from cost considerations, imaging at 3T delivers higher signal to noise (SNR) enabling increased spatial resolution, critical for identification of smaller white matter tracts and changes that may result from injury or disease.
1/8
August 25, 2025 at 1:47 PM
MR imaging at 1.5T vs 3T have different advantages. 🧠
Aside from cost considerations, imaging at 3T delivers higher signal to noise (SNR) enabling increased spatial resolution, critical for identification of smaller white matter tracts and changes that may result from injury or disease.
1/8
Aside from cost considerations, imaging at 3T delivers higher signal to noise (SNR) enabling increased spatial resolution, critical for identification of smaller white matter tracts and changes that may result from injury or disease.
1/8
August 17, 2025 at 7:19 PM
The scan was performed on a 3T
#MAGNUS system by GE Healthcare with high in-plane isotropic resolution (0.937 mm) and with 2.0mm slices, 3 non-diffusion weighted volumes and 50 gradient directions (b-value = 1000 s/mm2 ).
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#MAGNUS system by GE Healthcare with high in-plane isotropic resolution (0.937 mm) and with 2.0mm slices, 3 non-diffusion weighted volumes and 50 gradient directions (b-value = 1000 s/mm2 ).
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August 1, 2025 at 2:25 PM
The scan was performed on a 3T
#MAGNUS system by GE Healthcare with high in-plane isotropic resolution (0.937 mm) and with 2.0mm slices, 3 non-diffusion weighted volumes and 50 gradient directions (b-value = 1000 s/mm2 ).
(4/4)
#MAGNUS system by GE Healthcare with high in-plane isotropic resolution (0.937 mm) and with 2.0mm slices, 3 non-diffusion weighted volumes and 50 gradient directions (b-value = 1000 s/mm2 ).
(4/4)
We used FSL's bedpost and Fdt with spherical mask seed points (shown in yellow) and termination sphere masks shown in red. The 3D rendering shows the result as a mask.
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August 1, 2025 at 2:23 PM
We used FSL's bedpost and Fdt with spherical mask seed points (shown in yellow) and termination sphere masks shown in red. The 3D rendering shows the result as a mask.
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