practiCal fMRI
@practicalfmri.bsky.social
practicalfmri.blogspot.com
www.youtube.com/@practiCalfMRI
www.youtube.com/@practiCalfMRI
Label free, capillary-scale blood flow mapping in vivo reveals that low-intensity focused ultrasound evokes persistent dilation in cortical microvasculature
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Label free, capillary-scale blood flow mapping in vivo reveals that low-intensity focused ultrasound evokes persistent dilation in cortical microvasculature - Communications Biology
Capillary-scale blood flow mapping in vivo reveals that low intensity focused ultrasound evokes persistent dilation in cortical microvasculature
www.nature.com
November 19, 2025 at 9:36 AM
Label free, capillary-scale blood flow mapping in vivo reveals that low-intensity focused ultrasound evokes persistent dilation in cortical microvasculature
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Kilohertz transcranial magnetic perturbation (kTMP) as a new non-invasive method to modulate cortical excitability
pubmed.ncbi.nlm.nih.gov/40899987/
pubmed.ncbi.nlm.nih.gov/40899987/
Kilohertz transcranial magnetic perturbation (kTMP) as a new non-invasive method to modulate cortical excitability - PubMed
Non-invasive brain stimulation (NIBS) provides a method for safely perturbing brain activity, and has been employed in basic research to test hypotheses concerning brain-behavior relationships with increasing translational applications. We introduce and evaluate a novel subthreshold NIBS method: kil …
pubmed.ncbi.nlm.nih.gov
November 19, 2025 at 8:39 AM
Kilohertz transcranial magnetic perturbation (kTMP) as a new non-invasive method to modulate cortical excitability
pubmed.ncbi.nlm.nih.gov/40899987/
pubmed.ncbi.nlm.nih.gov/40899987/
Reposted by practiCal fMRI
Deep cerebellar tFUS engages cortical circuits via convergent local and sensory-driven mechanisms https://www.biorxiv.org/content/10.1101/2025.11.15.688639v1
November 16, 2025 at 10:16 AM
Deep cerebellar tFUS engages cortical circuits via convergent local and sensory-driven mechanisms https://www.biorxiv.org/content/10.1101/2025.11.15.688639v1
For anyone now freaking out, remember there are three legs to the AI/ML/DL stool: 1. the hardware & power to do the computations, 2. the algo/model being deployed, and 3. the data. Collecting good data may never have been so important.
November 16, 2025 at 4:25 PM
For anyone now freaking out, remember there are three legs to the AI/ML/DL stool: 1. the hardware & power to do the computations, 2. the algo/model being deployed, and 3. the data. Collecting good data may never have been so important.
AI Is Suddenly Surprisingly Good At Physics
YouTube video by Sabine Hossenfelder
youtu.be
November 16, 2025 at 4:20 PM
Not quite ready for routine use, but a big step towards what would be a wonderful scan to include in all fMRI protocols. It gets a variable delay ASL, angio and variable contrast T1 anatomical all from the same set of data!
pubmed.ncbi.nlm.nih.gov/40955094/
pubmed.ncbi.nlm.nih.gov/40955094/
Combined angiography and perfusion using radial imaging and arterial spin labeling with structural contrast - PubMed
CAPRIA+S is an efficient single acquisition to provide intrinsically co-registered quantitative information about brain blood flow and structure that has considerable advantages over conventional methods.
pubmed.ncbi.nlm.nih.gov
November 15, 2025 at 2:38 AM
Not quite ready for routine use, but a big step towards what would be a wonderful scan to include in all fMRI protocols. It gets a variable delay ASL, angio and variable contrast T1 anatomical all from the same set of data!
pubmed.ncbi.nlm.nih.gov/40955094/
pubmed.ncbi.nlm.nih.gov/40955094/
Calling electrical engineers, what do you think of the suggestion that there's a capacitive E field between the transducer and the brain which contributes at least some of the neuromodulatory effects of tFUS? Presumably this DC effect would manifest at the pulse repetition rate.
Non-invasive in vivo acoustoelectric neuromodulation and its contribution to ultrasound stimulation https://www.biorxiv.org/content/10.1101/2025.11.02.685597v1
November 9, 2025 at 3:47 PM
Calling electrical engineers, what do you think of the suggestion that there's a capacitive E field between the transducer and the brain which contributes at least some of the neuromodulatory effects of tFUS? Presumably this DC effect would manifest at the pulse repetition rate.
Reposted by practiCal fMRI
Non-invasive in vivo acoustoelectric neuromodulation and its contribution to ultrasound stimulation https://www.biorxiv.org/content/10.1101/2025.11.02.685597v1
November 4, 2025 at 1:16 PM
Non-invasive in vivo acoustoelectric neuromodulation and its contribution to ultrasound stimulation https://www.biorxiv.org/content/10.1101/2025.11.02.685597v1
Decoding paradoxical BOLD responses to transcranial ultrasound stimulation with concurrent optoacoustic magnetic resonance imaging
pubmed.ncbi.nlm.nih.gov/41171932/
pubmed.ncbi.nlm.nih.gov/41171932/
Decoding paradoxical BOLD responses to transcranial ultrasound stimulation with concurrent optoacoustic magnetic resonance imaging - PubMed
Focused transcranial ultrasound stimulation (TUS) can affect neural activity with high spatial precision, advancing noninvasive neuromodulation toward targeted treatment of brain disorders. Direct monitoring of TUS responses is crucial for ensuring optimal outcomes. Blood-oxygenation-level-dependent …
pubmed.ncbi.nlm.nih.gov
November 4, 2025 at 6:17 PM
Decoding paradoxical BOLD responses to transcranial ultrasound stimulation with concurrent optoacoustic magnetic resonance imaging
pubmed.ncbi.nlm.nih.gov/41171932/
pubmed.ncbi.nlm.nih.gov/41171932/
Reposted by practiCal fMRI
Psychedelics alter neurovascular coupling, which means we need to critically re-evaluate fMRI findings of acute psychedelic effects
#neuroskyence
#PsychSciSky
www.nature.com/articles/s41...
#neuroskyence
#PsychSciSky
www.nature.com/articles/s41...
Psychedelic 5-HT2A receptor agonism alters neurovascular coupling and differentially affects neuronal and hemodynamic measures of brain function - Nature Neuroscience
Padawer-Curry et al. show that the hallucinogenic 5-HT2A receptor agonist DOI alters neurovascular coupling in mice, with implications for the interpretation of human fMRI studies of psychedelics.
www.nature.com
October 27, 2025 at 7:07 PM
Psychedelics alter neurovascular coupling, which means we need to critically re-evaluate fMRI findings of acute psychedelic effects
#neuroskyence
#PsychSciSky
www.nature.com/articles/s41...
#neuroskyence
#PsychSciSky
www.nature.com/articles/s41...
Reposted by practiCal fMRI
High frequency oscillations measured with optically pumped magnetometers from the human retina https://www.biorxiv.org/content/10.1101/2025.10.27.683907v1
October 27, 2025 at 7:15 PM
High frequency oscillations measured with optically pumped magnetometers from the human retina https://www.biorxiv.org/content/10.1101/2025.10.27.683907v1
Reposted by practiCal fMRI
Lipid composition and mechanical force underlie multi-modal regulation of Piezo1 gating https://www.biorxiv.org/content/10.1101/2025.10.24.684433v1
October 25, 2025 at 8:47 AM
Lipid composition and mechanical force underlie multi-modal regulation of Piezo1 gating https://www.biorxiv.org/content/10.1101/2025.10.24.684433v1
If metabolic water production rate can explain a good 90%+ of MSM washout from brain tissue then there isn't a whole lot of need for CSF influx (via glymphatic, perivascular or any other routes) to account for tissue clearance. Perhaps we've been barking up the wrong tree? (2/2)
Interesting observation du jour... In 2020 we reported MSM (aka DMSO2) washout from brain, getting a half-life of 72 hrs (10.1002/mrm.27997, Fig 5C). Metabolic water production of 0.11 µL/g/min (~15% wt/wt turnover per day) as estimated here accounts for almost all the MSM clearance we saw. (1/2)
A budget for brain metabolic water production by glucose catabolism during rest, rises in activity and sleep
pubmed.ncbi.nlm.nih.gov/40329309/
pubmed.ncbi.nlm.nih.gov/40329309/
October 23, 2025 at 11:15 AM
If metabolic water production rate can explain a good 90%+ of MSM washout from brain tissue then there isn't a whole lot of need for CSF influx (via glymphatic, perivascular or any other routes) to account for tissue clearance. Perhaps we've been barking up the wrong tree? (2/2)
Interesting observation du jour... In 2020 we reported MSM (aka DMSO2) washout from brain, getting a half-life of 72 hrs (10.1002/mrm.27997, Fig 5C). Metabolic water production of 0.11 µL/g/min (~15% wt/wt turnover per day) as estimated here accounts for almost all the MSM clearance we saw. (1/2)
A budget for brain metabolic water production by glucose catabolism during rest, rises in activity and sleep
pubmed.ncbi.nlm.nih.gov/40329309/
pubmed.ncbi.nlm.nih.gov/40329309/
A budget for brain metabolic water production by glucose catabolism during rest, rises in activity and sleep - PubMed
Maintaining brain fluid homeostasis is of critical importance for creating a stable environment conducive to optimal neuronal functioning, nutrient distribution, and waste product removal. In this stu...
pubmed.ncbi.nlm.nih.gov
October 23, 2025 at 11:10 AM
Interesting observation du jour... In 2020 we reported MSM (aka DMSO2) washout from brain, getting a half-life of 72 hrs (10.1002/mrm.27997, Fig 5C). Metabolic water production of 0.11 µL/g/min (~15% wt/wt turnover per day) as estimated here accounts for almost all the MSM clearance we saw. (1/2)
A budget for brain metabolic water production by glucose catabolism during rest, rises in activity and sleep
pubmed.ncbi.nlm.nih.gov/40329309/
pubmed.ncbi.nlm.nih.gov/40329309/
A budget for brain metabolic water production by glucose catabolism during rest, rises in activity and sleep - PubMed
Maintaining brain fluid homeostasis is of critical importance for creating a stable environment conducive to optimal neuronal functioning, nutrient distribution, and waste product removal. In this stu...
pubmed.ncbi.nlm.nih.gov
October 22, 2025 at 4:53 PM
A budget for brain metabolic water production by glucose catabolism during rest, rises in activity and sleep
pubmed.ncbi.nlm.nih.gov/40329309/
pubmed.ncbi.nlm.nih.gov/40329309/
Reposted by practiCal fMRI
Indirect Deuterium Displacement Exchange Imaging for Non-invasive High-Resolution CSF Production Mapping https://www.biorxiv.org/content/10.1101/2025.10.20.683579v1
October 22, 2025 at 4:15 AM
Indirect Deuterium Displacement Exchange Imaging for Non-invasive High-Resolution CSF Production Mapping https://www.biorxiv.org/content/10.1101/2025.10.20.683579v1
Region-specific drivers of CSF mobility measured with MRI in humans
pubmed.ncbi.nlm.nih.gov/41087750/
pubmed.ncbi.nlm.nih.gov/41087750/
Region-specific drivers of CSF mobility measured with MRI in humans - PubMed
Many neurological diseases are characterized by the accumulation of toxic proteins in the brain. This accumulation has been associated with improper clearance from the parenchyma. Recent discoveries h...
pubmed.ncbi.nlm.nih.gov
October 20, 2025 at 10:04 PM
Region-specific drivers of CSF mobility measured with MRI in humans
pubmed.ncbi.nlm.nih.gov/41087750/
pubmed.ncbi.nlm.nih.gov/41087750/
Reposted by practiCal fMRI
🎤 Calling Multi-Echo fMRI Researchers 🎤
Preparing for OHBM? Get expert feedback before the deadline! 🌟
Tedana devs will possibly host a multi-echo meeting on Dec 8th to make sure your abstract is perfect for submission.
Interested? DM me or other tedana devs!
#neuroskyence #neuroimaging
Preparing for OHBM? Get expert feedback before the deadline! 🌟
Tedana devs will possibly host a multi-echo meeting on Dec 8th to make sure your abstract is perfect for submission.
Interested? DM me or other tedana devs!
#neuroskyence #neuroimaging
October 16, 2025 at 4:14 PM
🎤 Calling Multi-Echo fMRI Researchers 🎤
Preparing for OHBM? Get expert feedback before the deadline! 🌟
Tedana devs will possibly host a multi-echo meeting on Dec 8th to make sure your abstract is perfect for submission.
Interested? DM me or other tedana devs!
#neuroskyence #neuroimaging
Preparing for OHBM? Get expert feedback before the deadline! 🌟
Tedana devs will possibly host a multi-echo meeting on Dec 8th to make sure your abstract is perfect for submission.
Interested? DM me or other tedana devs!
#neuroskyence #neuroimaging
Differentiating BOLD and non-BOLD signals in fMRI time series using cross-cortical depth delay patterns
pubmed.ncbi.nlm.nih.gov/41064374/
pubmed.ncbi.nlm.nih.gov/41064374/
Differentiating BOLD and non-BOLD signals in fMRI time series using cross-cortical depth delay patterns - PubMed
Over the past two decades, rapid advancements in magnetic resonance technology have significantly enhanced the imaging resolution of functional Magnetic Resonance Imaging (fMRI), far surpassing its in...
pubmed.ncbi.nlm.nih.gov
October 13, 2025 at 12:18 PM
Differentiating BOLD and non-BOLD signals in fMRI time series using cross-cortical depth delay patterns
pubmed.ncbi.nlm.nih.gov/41064374/
pubmed.ncbi.nlm.nih.gov/41064374/
Reposted by practiCal fMRI
Arousal increases locus coeruleus blood flow, salience-related brain responses, and modulates negative-valence attentional biases https://www.biorxiv.org/content/10.1101/2025.10.07.680973v1
October 8, 2025 at 4:15 AM
Arousal increases locus coeruleus blood flow, salience-related brain responses, and modulates negative-valence attentional biases https://www.biorxiv.org/content/10.1101/2025.10.07.680973v1
WATCH: 3 scientists who helped advance quantum technology win Nobel Prize in physics www.pbs.org/newshour/sci...
WATCH: 3 scientists who helped advance quantum technology win Nobel Prize in physics
John Clarke, Michel H. Devoret and John M. Martinis won the Nobel Prize in Physics on Tuesday for research on seemingly obscure quantum tunneling that is advancing digital technology.
www.pbs.org
October 7, 2025 at 11:02 PM
WATCH: 3 scientists who helped advance quantum technology win Nobel Prize in physics www.pbs.org/newshour/sci...
Predicting Regional Cerebral Blood Flow Using Voxel-Wise Resting-State Functional MRI
pubmed.ncbi.nlm.nih.gov/41008269/
pubmed.ncbi.nlm.nih.gov/41008269/
Predicting Regional Cerebral Blood Flow Using Voxel-Wise Resting-State Functional MRI - PubMed
<span><b>Background:</b> Regional cerebral blood flow (rCBF) is a putative biomarker for neuropsychiatric disorders, including major depressive disorder (MDD). <b>Methods:</b> Here, we show that rCBF ...
pubmed.ncbi.nlm.nih.gov
September 30, 2025 at 11:24 AM
Predicting Regional Cerebral Blood Flow Using Voxel-Wise Resting-State Functional MRI
pubmed.ncbi.nlm.nih.gov/41008269/
pubmed.ncbi.nlm.nih.gov/41008269/
Reposted by practiCal fMRI
New paper in Imaging Neuroscience by Roza G. Bayrak, Catie Chang, et al:
DeepPhysioRecon: Tracing peripheral physiology in low frequency fMRI dynamics
doi.org/10.1162/IMAG...
DeepPhysioRecon: Tracing peripheral physiology in low frequency fMRI dynamics
doi.org/10.1162/IMAG...
September 26, 2025 at 8:40 AM
New paper in Imaging Neuroscience by Roza G. Bayrak, Catie Chang, et al:
DeepPhysioRecon: Tracing peripheral physiology in low frequency fMRI dynamics
doi.org/10.1162/IMAG...
DeepPhysioRecon: Tracing peripheral physiology in low frequency fMRI dynamics
doi.org/10.1162/IMAG...
Thinking about Angelo Mosso's brain balance method recently. There was a confound not mentioned in a 2014 review (pubmed.ncbi.nlm.nih.gov/23687118/). Blood is 1.06 X water density, but CSF will be forced out of the ventricles as CBV increases (Monro-Kellie doctrine) so net weight sensitivity is low.
Weighing brain activity with the balance: Angelo Mosso's original manuscripts come to light - PubMed
Neuroimaging techniques, such as positron emission tomography and functional magnetic resonance imaging are essential tools for the analysis of organized neural systems in working and resting states, ...
pubmed.ncbi.nlm.nih.gov
September 26, 2025 at 2:02 AM
Thinking about Angelo Mosso's brain balance method recently. There was a confound not mentioned in a 2014 review (pubmed.ncbi.nlm.nih.gov/23687118/). Blood is 1.06 X water density, but CSF will be forced out of the ventricles as CBV increases (Monro-Kellie doctrine) so net weight sensitivity is low.
Brain thermal response to low intensity focused ultrasound at the action potential level and neuron response to various stimulus
pubmed.ncbi.nlm.nih.gov/40967140/
pubmed.ncbi.nlm.nih.gov/40967140/
Brain thermal response to low intensity focused ultrasound at the action potential level and neuron response to various stimulus - PubMed
Ultrasound neuromodulation is a non-invasive technique that modulates neuronal activity through energy transfer or mechanical effects. Understanding how focused ultrasound (FUS) influences neuronal st...
pubmed.ncbi.nlm.nih.gov
September 23, 2025 at 8:13 PM
Brain thermal response to low intensity focused ultrasound at the action potential level and neuron response to various stimulus
pubmed.ncbi.nlm.nih.gov/40967140/
pubmed.ncbi.nlm.nih.gov/40967140/