PolyBio Research Foundation
@polybiorf.bsky.social
501(c)3 transforming how #LongCovid, #ME/CFS & Lyme+ are studied, diagnosed, and treated. Leading the #LongCovid Research Consortium.
PolyBio and WE&ME supported study identifies two distinct ME/CFS subtypes
🧪Collaborative research uncovers immune and biomarker patterns that could help subclassify ME/CFS and guide future treatments.
polybio.org/polybio-and-...
🧪Collaborative research uncovers immune and biomarker patterns that could help subclassify ME/CFS and guide future treatments.
polybio.org/polybio-and-...
May 20, 2025 at 3:27 PM
PolyBio and WE&ME supported study identifies two distinct ME/CFS subtypes
🧪Collaborative research uncovers immune and biomarker patterns that could help subclassify ME/CFS and guide future treatments.
polybio.org/polybio-and-...
🧪Collaborative research uncovers immune and biomarker patterns that could help subclassify ME/CFS and guide future treatments.
polybio.org/polybio-and-...
PolyBio’s Spring Symposium is approaching fast—on May 16, watch exciting project updates on clinical trials, tissue pipelines, immune & metabolism findings on infection-associated chronic illnesses.
Sign up now: us02web.zoom.us/webinar/regi...
Sign up now: us02web.zoom.us/webinar/regi...
May 8, 2025 at 12:09 AM
PolyBio’s Spring Symposium is approaching fast—on May 16, watch exciting project updates on clinical trials, tissue pipelines, immune & metabolism findings on infection-associated chronic illnesses.
Sign up now: us02web.zoom.us/webinar/regi...
Sign up now: us02web.zoom.us/webinar/regi...
Post-treatment Lyme Disease patients with chronic pain in the US—consider participating in this decentralized study (completely virtual). It’s run via the CoRE clinic under the direction of Drs. David Putrino and Amy Proal @putrinolab.bsky.social @coresinai.bsky.social
May 2, 2025 at 3:21 PM
Post-treatment Lyme Disease patients with chronic pain in the US—consider participating in this decentralized study (completely virtual). It’s run via the CoRE clinic under the direction of Drs. David Putrino and Amy Proal @putrinolab.bsky.social @coresinai.bsky.social
The PolyBio-supported study on elevated plasma proteins associated with breathlessness in Long COVID was featured in an article in Technology Networks : www.technologynetworks.com/tn/news/long...
May 1, 2025 at 4:48 PM
The PolyBio-supported study on elevated plasma proteins associated with breathlessness in Long COVID was featured in an article in Technology Networks : www.technologynetworks.com/tn/news/long...
Calling all Long Covid, ME/CFS and Post-Treatment Lyme patients in the Boston area! This PolyBio-supported study is now seeking participants.
Participants must be able to attend an in-person visit at Brigham & Women’s hospital in Boston to participate.
Email [email protected] if interested
Participants must be able to attend an in-person visit at Brigham & Women’s hospital in Boston to participate.
Email [email protected] if interested
April 18, 2025 at 6:09 PM
Calling all Long Covid, ME/CFS and Post-Treatment Lyme patients in the Boston area! This PolyBio-supported study is now seeking participants.
Participants must be able to attend an in-person visit at Brigham & Women’s hospital in Boston to participate.
Email [email protected] if interested
Participants must be able to attend an in-person visit at Brigham & Women’s hospital in Boston to participate.
Email [email protected] if interested
We’re truly excited that the PolyBio supported Low-dose Rapamycin trial is now recruiting in the NYC area.
Interested in learning more? Here’s the full study summary: polybio.org/projects/lon...
Interested in learning more? Here’s the full study summary: polybio.org/projects/lon...
April 15, 2025 at 3:16 PM
We’re truly excited that the PolyBio supported Low-dose Rapamycin trial is now recruiting in the NYC area.
Interested in learning more? Here’s the full study summary: polybio.org/projects/lon...
Interested in learning more? Here’s the full study summary: polybio.org/projects/lon...
4/ In the UCSF project, the EXPLORER PET scanner used in this study is the first FDA-approved full-body PET scanner & was created by two members of the project team. It has 40x the sensitivity of commercial scanners,
March 28, 2025 at 6:13 PM
4/ In the UCSF project, the EXPLORER PET scanner used in this study is the first FDA-approved full-body PET scanner & was created by two members of the project team. It has 40x the sensitivity of commercial scanners,
2/ This PolyBio-supported project at UCSF is working to develop similar imaging methods. The goal is to detect spike protein associated with SARS-CoV-2 reservoirs throughout the body & brains of long COVID patients: polybio.org/projects/use...
March 28, 2025 at 6:13 PM
2/ This PolyBio-supported project at UCSF is working to develop similar imaging methods. The goal is to detect spike protein associated with SARS-CoV-2 reservoirs throughout the body & brains of long COVID patients: polybio.org/projects/use...
Dr. Rigel Chan is investigating SARS-CoV-2’s impact on the development of #Alzheimers. His work has found that S protein levels in cells aren’t associated with AD, “but exposure to antigens like Spike may alter the conditions such that [patients] become more susceptible to HSV1.”
March 21, 2025 at 7:13 PM
Dr. Rigel Chan is investigating SARS-CoV-2’s impact on the development of #Alzheimers. His work has found that S protein levels in cells aren’t associated with AD, “but exposure to antigens like Spike may alter the conditions such that [patients] become more susceptible to HSV1.”
2/ The project is expanding the PolyBio-supported POstmortemSystematic InvesTigation of Sudden Cardiac Death autopsy study to examine key questions regarding Long COVID:
🦠What’s the tissue distribution and burden of SCV2 RNA/proteins in tissues of sudden death victims with and without Long Covid?
🦠What’s the tissue distribution and burden of SCV2 RNA/proteins in tissues of sudden death victims with and without Long Covid?
March 18, 2025 at 8:45 PM
2/ The project is expanding the PolyBio-supported POstmortemSystematic InvesTigation of Sudden Cardiac Death autopsy study to examine key questions regarding Long COVID:
🦠What’s the tissue distribution and burden of SCV2 RNA/proteins in tissues of sudden death victims with and without Long Covid?
🦠What’s the tissue distribution and burden of SCV2 RNA/proteins in tissues of sudden death victims with and without Long Covid?
Dr. Zian Tseng has been studying sudden cardiac deaths since 2011–and is now using those data to compare to SCDs post-COVID. “A post-2020 person who recovered from COVID… died suddenly from their acute myocardial infarction. We found SARS-CoV-2 Spike RNA in their brain [tissue].”
March 18, 2025 at 8:45 PM
Dr. Zian Tseng has been studying sudden cardiac deaths since 2011–and is now using those data to compare to SCDs post-COVID. “A post-2020 person who recovered from COVID… died suddenly from their acute myocardial infarction. We found SARS-CoV-2 Spike RNA in their brain [tissue].”
Dr. David Price is investigating the role of lung dysfunction in Long Covid: “We’re sampling bronchoalveolar lavage fluid and transbronchial biopsies… what we plan to do is metagenomics, metatranscriptomics & RNA seq… to get some idea of the pathogenesis of LC at the site of initial infection.”
March 11, 2025 at 7:41 PM
Dr. David Price is investigating the role of lung dysfunction in Long Covid: “We’re sampling bronchoalveolar lavage fluid and transbronchial biopsies… what we plan to do is metagenomics, metatranscriptomics & RNA seq… to get some idea of the pathogenesis of LC at the site of initial infection.”
Dr. Petter Brodin is leading a project investigating the genetic determinants of Long Covid. “We’re currently looking for genetic variants that could explain why [Long Covid patients] have what we think is impaired antiviral immunity, leading to viral persistence.”
March 8, 2025 at 12:20 AM
Dr. Petter Brodin is leading a project investigating the genetic determinants of Long Covid. “We’re currently looking for genetic variants that could explain why [Long Covid patients] have what we think is impaired antiviral immunity, leading to viral persistence.”
3/ PolyBio is supporting Dr. Iwasaki’s current research that probes the relationship between HERV activity, viral and bacterial pathogen reactivation, and Long Covid pathogenesis.
Read more: polybio.org/projects/pro...
Read more: polybio.org/projects/pro...
March 5, 2025 at 6:31 PM
3/ PolyBio is supporting Dr. Iwasaki’s current research that probes the relationship between HERV activity, viral and bacterial pathogen reactivation, and Long Covid pathogenesis.
Read more: polybio.org/projects/pro...
Read more: polybio.org/projects/pro...
Dr. Akiko Iwasaki, who has led work on the role of human endogenous retroviruses (HERVs) in chronic diseases i.e. lupus, is now investigating the role of HERVs in Long Covid.
March 5, 2025 at 6:31 PM
Dr. Akiko Iwasaki, who has led work on the role of human endogenous retroviruses (HERVs) in chronic diseases i.e. lupus, is now investigating the role of HERVs in Long Covid.
2/ Patient samples will be sent to Dr. Akiko Iwasaki’s lab for infectious & immune testing to help determine the biological parameters of patients who may respond to the drug. “We can use that data to ‘select-in’ those patients that show those biological characteristics of responders.”
February 26, 2025 at 5:06 PM
2/ Patient samples will be sent to Dr. Akiko Iwasaki’s lab for infectious & immune testing to help determine the biological parameters of patients who may respond to the drug. “We can use that data to ‘select-in’ those patients that show those biological characteristics of responders.”
“We’re trialing a low dose of Rapamycin once a week… which may have an immune-supporting effect,” Dr. Proal explained last week via the CoRE clinic. There are a couple studies that show this low dose could improve signalling of interferons… used to control viral infections.”
February 26, 2025 at 5:06 PM
“We’re trialing a low dose of Rapamycin once a week… which may have an immune-supporting effect,” Dr. Proal explained last week via the CoRE clinic. There are a couple studies that show this low dose could improve signalling of interferons… used to control viral infections.”
Dr. Amy Proal, Scientific Director of the CoRE Clinic at Mount Sinai, discusses viral persistence as a driver of ME/CFS with Dr.s Raven Baxter & David Putrino: “[research] finds the RNA backbone & protein of enteroviruses in ME/CFS gut tissue.” @coresinai.bsky.social
February 18, 2025 at 10:57 PM
Dr. Amy Proal, Scientific Director of the CoRE Clinic at Mount Sinai, discusses viral persistence as a driver of ME/CFS with Dr.s Raven Baxter & David Putrino: “[research] finds the RNA backbone & protein of enteroviruses in ME/CFS gut tissue.” @coresinai.bsky.social
2/ The project is supported by the Cohen Foundation, but amplified and directed by PolyBio and the CoRE clinic at Mount Sinai, which collects and ships the LC, ME & EDS blood samples for the study.
Read more here: polybio.org/projects/imp...
Read more here: polybio.org/projects/imp...
February 14, 2025 at 5:22 PM
2/ The project is supported by the Cohen Foundation, but amplified and directed by PolyBio and the CoRE clinic at Mount Sinai, which collects and ships the LC, ME & EDS blood samples for the study.
Read more here: polybio.org/projects/imp...
Read more here: polybio.org/projects/imp...
Dr. Ed Breitschwerdt is investigating the proportion of Long Covid, ME & EDS patients with Borrelia, Babesia and Bartonella in their blood using a highly accurate ddPCR assay. “We’ve seen every combination of infection, from only 1 organism to co-infection with all 3.”
February 14, 2025 at 5:22 PM
Dr. Ed Breitschwerdt is investigating the proportion of Long Covid, ME & EDS patients with Borrelia, Babesia and Bartonella in their blood using a highly accurate ddPCR assay. “We’ve seen every combination of infection, from only 1 organism to co-infection with all 3.”
2/ Read more about this PolyBio-supported study of Larazotide for Paediatric Long Covid here: polybio.org/projects/sar...
February 7, 2025 at 5:23 PM
2/ Read more about this PolyBio-supported study of Larazotide for Paediatric Long Covid here: polybio.org/projects/sar...
Children with Long Covid who received Larazotide for GI symptoms reported a fast & sustained recovery following treatment vs. controls.
February 7, 2025 at 5:23 PM
Children with Long Covid who received Larazotide for GI symptoms reported a fast & sustained recovery following treatment vs. controls.
2/ PolyBio is supporting this pilot autopsy program to allow rapid preservation of brain, lungs, liver, GI tract & lymphoid tissues. Dr. Harris & Georgetown colleagues will be focusing on signals senescence in the CNS tissues. NIH will focus on viral detection. Read more: polybio.org/projects/dev...
February 7, 2025 at 5:14 PM
2/ PolyBio is supporting this pilot autopsy program to allow rapid preservation of brain, lungs, liver, GI tract & lymphoid tissues. Dr. Harris & Georgetown colleagues will be focusing on signals senescence in the CNS tissues. NIH will focus on viral detection. Read more: polybio.org/projects/dev...
Dr. Brent Harris & colleagues at NIH are forming a rapid autopsy program to assess SARS-CoV-2’s effects on body tissues, focusing on the brain. “NIH will focus on detection of RNA, proteins & replication-competent virus… using RNA scope [we’ve] found a wide persistence of SCV2.”
February 7, 2025 at 5:14 PM
Dr. Brent Harris & colleagues at NIH are forming a rapid autopsy program to assess SARS-CoV-2’s effects on body tissues, focusing on the brain. “NIH will focus on detection of RNA, proteins & replication-competent virus… using RNA scope [we’ve] found a wide persistence of SCV2.”
3/ Read more here: polybio.org/projects/sar...
January 31, 2025 at 8:02 PM
3/ Read more here: polybio.org/projects/sar...