Patrick McCarren
@pmc11.bsky.social
Computational chemist working in drug discovery. Someday I’ll fill in a little more.
Reposted by Patrick McCarren
Particularly of interest to people who want to do protein design in an academic environment w/ many colleagues in basic science (cancer biology, cell signaling, immunology, virology) & clinicians who can drive the discovery of new targets for hard-to-treat diseases & bring therapeutics to patients.
The Cancer Signaling & Microenvironment Program at Fox Chase Cancer Center is looking for tenure track faculty (assist./assoc./full) in computational & experimental protein design. CV & 3-page research statement by Feb 15.
More info here:
www.linkedin.com/feed/update/...
Questions: DM/Email me.
More info here:
www.linkedin.com/feed/update/...
Questions: DM/Email me.
Now hiring: Tenure-track faculty (Asst/Assoc/Full) in Computational & Experimental Protein Design at Fox Chase Cancer Center, Philadelphia PA
Join the Cancer Signaling & Microenvironment Pro...
Now hiring: Tenure-track faculty (Asst/Assoc/Full) in Computational & Experimental Protein Design at Fox Chase Cancer Center, Philadelphia PA
Join the Cancer Signaling & Microenvironment Program at ...
www.linkedin.com
January 19, 2026 at 9:38 PM
Particularly of interest to people who want to do protein design in an academic environment w/ many colleagues in basic science (cancer biology, cell signaling, immunology, virology) & clinicians who can drive the discovery of new targets for hard-to-treat diseases & bring therapeutics to patients.
Reposted by Patrick McCarren
The perfect story to take your mind off other news:
Veronika, a cow in Austria, has been documented not only using a tool - a broomstick - but using it in different ways to scratch different parts of her body. 🧪 #animals #animalbehavior #intelligence
www.livescience.com/animals/land...
Veronika, a cow in Austria, has been documented not only using a tool - a broomstick - but using it in different ways to scratch different parts of her body. 🧪 #animals #animalbehavior #intelligence
www.livescience.com/animals/land...
Ever seen a pet cow pick up a broom and scratch herself with it? You have now
A pet cow in Austria started using a broom to scratch herself — the first ever documented case of bovine tool use.
www.livescience.com
January 19, 2026 at 7:08 PM
The perfect story to take your mind off other news:
Veronika, a cow in Austria, has been documented not only using a tool - a broomstick - but using it in different ways to scratch different parts of her body. 🧪 #animals #animalbehavior #intelligence
www.livescience.com/animals/land...
Veronika, a cow in Austria, has been documented not only using a tool - a broomstick - but using it in different ways to scratch different parts of her body. 🧪 #animals #animalbehavior #intelligence
www.livescience.com/animals/land...
Reposted by Patrick McCarren
🧪🛟 sociology 📈 demography
Dr. Gladys West, the pioneering mathematician whose work laid the foundation for modern GPS technology, has died. She was 95.
Dr. Gladys West, Mathematician Whose Work Made GPS Possible, Dies at 95
ALEXANDRIA, VA — Dr. Gladys West, the pioneering mathematician whose work laid the foundation for modern GPS technology, has died. She passed away
thezebra.org
January 19, 2026 at 8:22 PM
🧪🛟 sociology 📈 demography
Reposted by Patrick McCarren
A misunderstanding a federal judge in DC highlighted just last month www.politico.com/news/2025/12...
January 18, 2026 at 2:10 AM
A misunderstanding a federal judge in DC highlighted just last month www.politico.com/news/2025/12...
Reposted by Patrick McCarren
The GOP is destroying America bit by bit. We need to boot them out of power in November. Who’s with me?
January 12, 2026 at 2:00 AM
The GOP is destroying America bit by bit. We need to boot them out of power in November. Who’s with me?
Reposted by Patrick McCarren
This is insane. www.whitehouse.gov/presidential...
Withdrawing the United States from International Organizations, Conventions, and Treaties that Are Contrary to the Interests of the United States
MEMORANDUM FOR THE HEADS OF EXECUTIVE DEPARTMENTS AND AGENCIES By the authority vested in me as President by the Constitution and the laws of the United
www.whitehouse.gov
January 8, 2026 at 1:39 AM
This is insane. www.whitehouse.gov/presidential...
Reposted by Patrick McCarren
Poppies are a symbol of remembrance on Armistice Day. Did you know that some poppies are also the source of powerful opioid painkillers?
Find out more in this graphic: www.compoundchem.com/2020/11/11/p...
#ChemSky 🧪
Find out more in this graphic: www.compoundchem.com/2020/11/11/p...
#ChemSky 🧪
November 11, 2025 at 9:51 AM
Poppies are a symbol of remembrance on Armistice Day. Did you know that some poppies are also the source of powerful opioid painkillers?
Find out more in this graphic: www.compoundchem.com/2020/11/11/p...
#ChemSky 🧪
Find out more in this graphic: www.compoundchem.com/2020/11/11/p...
#ChemSky 🧪
Reposted by Patrick McCarren
Really excited to see this in print - super work here by the wonderful team here from the @uwyoongroup.bsky.social
It was a real pleasure to watch this work evolve from a "what if" discussion to a @natsynth.nature.com paper
I truly appreciate being included #Chemsky
It was a real pleasure to watch this work evolve from a "what if" discussion to a @natsynth.nature.com paper
I truly appreciate being included #Chemsky
Oxygen migration into carbon–carbon single bonds by photochemical oxidation - Nature Synthesis
Heteroatom insertions into chemically inert carbon–carbon single bonds are rare compared to their unsaturated analogues. Now, ligand-to-metal charge transfer offers a promising entry point for oxygen ...
www.nature.com
November 11, 2025 at 12:55 AM
Really excited to see this in print - super work here by the wonderful team here from the @uwyoongroup.bsky.social
It was a real pleasure to watch this work evolve from a "what if" discussion to a @natsynth.nature.com paper
I truly appreciate being included #Chemsky
It was a real pleasure to watch this work evolve from a "what if" discussion to a @natsynth.nature.com paper
I truly appreciate being included #Chemsky
Reposted by Patrick McCarren
If you (or an undergraduate in your life) is thinking about graduate school in Chemistry, I want to share that Stony Brook Chemistry will be holding two virtual info sessions in about 2 weeks on our PhD program! Register: forms.gle/exxMufpr2dLv...
November 3, 2025 at 1:35 AM
If you (or an undergraduate in your life) is thinking about graduate school in Chemistry, I want to share that Stony Brook Chemistry will be holding two virtual info sessions in about 2 weeks on our PhD program! Register: forms.gle/exxMufpr2dLv...
Reposted by Patrick McCarren
The UC Regents finally released the “settlement agreement” the Trump administration proposed in August. It’s a doozy.
UC alumni, faculty, staff, students, parents, donors—and all citizens of California:
Now is the time to let the UC Regents know you do not want them to sign this bad deal.
UC alumni, faculty, staff, students, parents, donors—and all citizens of California:
Now is the time to let the UC Regents know you do not want them to sign this bad deal.
October 25, 2025 at 6:53 AM
The UC Regents finally released the “settlement agreement” the Trump administration proposed in August. It’s a doozy.
UC alumni, faculty, staff, students, parents, donors—and all citizens of California:
Now is the time to let the UC Regents know you do not want them to sign this bad deal.
UC alumni, faculty, staff, students, parents, donors—and all citizens of California:
Now is the time to let the UC Regents know you do not want them to sign this bad deal.
Reposted by Patrick McCarren
In the early days of quantum chemistry, before we had computers to calculate the shapes of electron orbitals, one man invented a mechanical machine that simulated their shapes. My latest column for @chemistryworld.com
www.chemistryworld.com/opinion/the-...
www.chemistryworld.com/opinion/the-...
The simple machine that visualised atomic orbitals
In 1931, Harvey Elliott White developed a device that traced out the shapes of electron clouds by approximating solutions to the Schrödinger equation
www.chemistryworld.com
September 18, 2025 at 9:37 AM
In the early days of quantum chemistry, before we had computers to calculate the shapes of electron orbitals, one man invented a mechanical machine that simulated their shapes. My latest column for @chemistryworld.com
www.chemistryworld.com/opinion/the-...
www.chemistryworld.com/opinion/the-...
Reposted by Patrick McCarren
Skala is now available to everyone!
Why are we releasing it? Because we’re not just aiming to publish a cool paper — we’re on a mission to bring DFT to chemical accuracy using deep learning. And to make real progress, we need the community’s feedback.
#compchem
Why are we releasing it? Because we’re not just aiming to publish a cool paper — we’re on a mission to bring DFT to chemical accuracy using deep learning. And to make real progress, we need the community’s feedback.
#compchem
The wait is over! Microsoft Research is sharing Skala, the new exchange-correlation functional, marking a major milestone in the accuracy/cost trade-off in DFT. Help us learn from your testing so we can improve. Available on Azure AI Foundry and GitHub. msft.it/6016sFDLY
October 9, 2025 at 4:46 PM
Skala is now available to everyone!
Why are we releasing it? Because we’re not just aiming to publish a cool paper — we’re on a mission to bring DFT to chemical accuracy using deep learning. And to make real progress, we need the community’s feedback.
#compchem
Why are we releasing it? Because we’re not just aiming to publish a cool paper — we’re on a mission to bring DFT to chemical accuracy using deep learning. And to make real progress, we need the community’s feedback.
#compchem
Reposted by Patrick McCarren
Almost the entire staff of Morbidity and Mortality Weekly Report, known as the “voice of the CDC,” has been laid off, former publication editor-in-chief Charlotte Kent told STAT Saturday.
www.statnews.com/2025/10/11/c...
www.statnews.com/2025/10/11/c...
Deep cuts made to CDC's flagship MMWR publication, a cornerstone of public health
CDC staff behind the agency’s flagship publication have been fired amid drastic cuts to the HHS promised by the White House due to the government shutdown, according to five people familiar with the s...
www.statnews.com
October 11, 2025 at 8:11 PM
Almost the entire staff of Morbidity and Mortality Weekly Report, known as the “voice of the CDC,” has been laid off, former publication editor-in-chief Charlotte Kent told STAT Saturday.
www.statnews.com/2025/10/11/c...
www.statnews.com/2025/10/11/c...
Reposted by Patrick McCarren
Great news!
JSTOR now have a free account with an Independent Researcher category. You can access 100 documents per month
www.jstor.org/action/showL...
JSTOR now have a free account with an Independent Researcher category. You can access 100 documents per month
www.jstor.org/action/showL...
September 29, 2025 at 3:27 PM
Great news!
JSTOR now have a free account with an Independent Researcher category. You can access 100 documents per month
www.jstor.org/action/showL...
JSTOR now have a free account with an Independent Researcher category. You can access 100 documents per month
www.jstor.org/action/showL...
Reposted by Patrick McCarren
In reporting this piece on the new trial for a Huntington's treatment, I was struck by one thing in particular:
The joy.
One of my sources wept for joy. He has spent his entire career studying this disease, he said it was the happiest day. www.sciencenews.org/article/hunt...
The joy.
One of my sources wept for joy. He has spent his entire career studying this disease, he said it was the happiest day. www.sciencenews.org/article/hunt...
Huntington's progression slowed by experimental gene therapy
An experimental gene therapy slowed Huntington’s by up to 75 percent in a small clinical trial. While not a cure, it may give patients longer lives.
www.sciencenews.org
September 26, 2025 at 5:58 PM
In reporting this piece on the new trial for a Huntington's treatment, I was struck by one thing in particular:
The joy.
One of my sources wept for joy. He has spent his entire career studying this disease, he said it was the happiest day. www.sciencenews.org/article/hunt...
The joy.
One of my sources wept for joy. He has spent his entire career studying this disease, he said it was the happiest day. www.sciencenews.org/article/hunt...
Reposted by Patrick McCarren
Reposted by Patrick McCarren
A proposed new rule would limit international students on F1 or J1 visas to stays in the US of no longer than 4 years. This effectively means that intl. students will no longer come to graduate school here (time to PhD is 5-6 years). You can comment here:
www.federalregister.gov/documents/20...
www.federalregister.gov/documents/20...
Establishing a Fixed Time Period of Admission and an Extension of Stay Procedure for Nonimmigrant Academic Students, Exchange Visitors, and Representatives of Foreign Information Media
Unlike most nonimmigrant classifications, which are admitted for a fixed time period, aliens in the F (academic student), J (exchange visitor), and most I (representatives of foreign information media...
www.federalregister.gov
September 3, 2025 at 7:39 PM
A proposed new rule would limit international students on F1 or J1 visas to stays in the US of no longer than 4 years. This effectively means that intl. students will no longer come to graduate school here (time to PhD is 5-6 years). You can comment here:
www.federalregister.gov/documents/20...
www.federalregister.gov/documents/20...
Reposted by Patrick McCarren
It’s outrageous that Sec. Kennedy is trying to fire the CDC Director — after only a few weeks on the job — for her commitment to public health & vaccines.
The Sen. HELP Committee must hold a hearing with Kennedy & the CDC Director as soon as possible.
Vaccines save lives. Period.
The Sen. HELP Committee must hold a hearing with Kennedy & the CDC Director as soon as possible.
Vaccines save lives. Period.
August 28, 2025 at 1:29 AM
It’s outrageous that Sec. Kennedy is trying to fire the CDC Director — after only a few weeks on the job — for her commitment to public health & vaccines.
The Sen. HELP Committee must hold a hearing with Kennedy & the CDC Director as soon as possible.
Vaccines save lives. Period.
The Sen. HELP Committee must hold a hearing with Kennedy & the CDC Director as soon as possible.
Vaccines save lives. Period.
Reposted by Patrick McCarren
UCLA Fields Medalist Terence Tao: "This is not a routine policy shift—it is a deliberate dismantling of the institutions, funding, and freedoms that have sustained American science for generations." newsletter.ofthebrave.org/p/im-an-awar... 🧪
I’m an award-winning mathematician. Trump just cut my funding.
The “Mozart of Math” tried to stay out of politics. Then it came for his research.
newsletter.ofthebrave.org
August 18, 2025 at 7:03 PM
UCLA Fields Medalist Terence Tao: "This is not a routine policy shift—it is a deliberate dismantling of the institutions, funding, and freedoms that have sustained American science for generations." newsletter.ofthebrave.org/p/im-an-awar... 🧪
Reposted by Patrick McCarren
Watching this video 10 times has significantly improved my mood.
August 17, 2025 at 9:05 PM
Watching this video 10 times has significantly improved my mood.
Reposted by Patrick McCarren
David Liu @harvard.edu beautifully articulates the criticality of basic science funding for developing revolutionary therapeutics like life-saving base editors 👏
youtu.be/8YhJM6zxYDw?...
youtu.be/8YhJM6zxYDw?...
Breakthrough Prize-Winning Biochemist on the Deadly Cost of Funding Cuts | Amanpour and Company
YouTube video by Amanpour and Company
youtu.be
May 24, 2025 at 1:13 AM
David Liu @harvard.edu beautifully articulates the criticality of basic science funding for developing revolutionary therapeutics like life-saving base editors 👏
youtu.be/8YhJM6zxYDw?...
youtu.be/8YhJM6zxYDw?...
Reposted by Patrick McCarren
Nothing says "we're the party of small government that's trying to stamp out government waste" like having US Attorneys investigate the editorial practices of academic journals read by a few thousand people.
April 17, 2025 at 11:45 PM
Nothing says "we're the party of small government that's trying to stamp out government waste" like having US Attorneys investigate the editorial practices of academic journals read by a few thousand people.