In our study @elife.bsky.social we uncover the mechanism of mPPase inhibition. Over 20x structures to date are in a symmetric form. We use EPR(PELDOR/DEER) and reveal asymmetric binding at the active site while maintaining symmetric conformation at periplasmic site

elifesciences.org/reviewed-pre...

We reviewed recent pulsed EPR Spectroscopy (PELDOR/DEER/PDS) applications on integral membrane proteins, enabled through Spin Labelling. Great to see the field moving forward!
www.sciencedirect.com/science/arti...