The Picower Institute for Learning and Memory at MIT
@picowerinstitute.bsky.social
A community of more than 250 MIT researchers dedicated to understanding the fundamental mechanisms of how the brain works and applying that insight to disease.
Research by the lab of Mriganka Sur in @cp-neuron.bsky.social: www.cell.com/neuron/abstr...
November 25, 2025 at 4:32 PM
Research by the lab of Mriganka Sur in @cp-neuron.bsky.social: www.cell.com/neuron/abstr...
Full study in @elife.bsky.social from the lab of @jtroylittleton.bsky.social: elifesciences.org/articles/108...
A stochastic RNA editing process targets a select number of sites in individual Drosophila glutamatergic motoneurons
Patch-seq RNA profiling defines the overall RNA editing landscape and single neuron editing rules for individual genetically defined Drosophila larval motoneurons.
elifesciences.org
November 20, 2025 at 5:29 PM
Full study in @elife.bsky.social from the lab of @jtroylittleton.bsky.social: elifesciences.org/articles/108...
Full study in @cp-cellreports.bsky.social www.cell.com/cell-reports...
Temporary retinal inactivation reverses effects of long-term monocular deprivation in visual cortex by induction of burst mode firing in the thalamus
Deprivation amblyopia can be reversed by the temporary inactivation of one eye after
the critical period. Here, Echevarri-Leet et al. show that this is caused by increased
burst firing in the neurons ...
www.cell.com
November 19, 2025 at 4:17 PM
Full study in @cp-cellreports.bsky.social www.cell.com/cell-reports...
Full study in @mitpress.bsky.social direct.mit.edu/jocn/article...
State–Space Trajectories and Traveling Waves Following Distraction
Abstract. Cortical activity shows the ability to recover from distractions. We analyzed neural activity from the pFC of monkeys performing working memory tasks with mid-memory delay distractions (a cu...
direct.mit.edu
October 31, 2025 at 12:49 PM
Full study in @mitpress.bsky.social direct.mit.edu/jocn/article...
Two late-onset patients who donated plasma each showed significant reductions in p-Tau 217. Two early onset patients did not show benefits. Full study: alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Gamma sensory stimulation in mild Alzheimer's dementia: An open‐label extension study
INTRODUCTION We evaluated the long-term effects of daily 40 Hz (gamma frequency) audiovisual stimulation on cognition and biomarkers in five patients with mild Alzheimer's disease (AD). METHODS Ov...
alz-journals.onlinelibrary.wiley.com
October 27, 2025 at 1:12 PM
Two late-onset patients who donated plasma each showed significant reductions in p-Tau 217. Two early onset patients did not show benefits. Full study: alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Full study from the lab of @earlkmiller.bsky.social: www.cell.com/neuron/abstr...
Working memory readout varies with frontal theta rhythms
Han et al. show that frontal theta oscillations rhythmically control access to working
memory. The theta rhythm sweeps across the mental image, shaping behavior by coordinating
spikes and beta oscilla...
www.cell.com
October 20, 2025 at 3:10 PM
Full study from the lab of @earlkmiller.bsky.social: www.cell.com/neuron/abstr...
Full study in @pnas.org: www.pnas.org/doi/10.1073/...
Engineered 3D immuno-glial-neurovascular human miBrain model | PNAS
Patient-specific, human-based cellular models integrating a biomimetic blood–brain
barrier, immune, and myelinated neuron components are critically...
www.pnas.org
October 17, 2025 at 7:20 PM
Full study in @pnas.org: www.pnas.org/doi/10.1073/...
Full study in @cp-iscience.bsky.social : www.cell.com/iscience/ful...
The noncoding circular RNA circHomer1 regulates synaptic development and experience-dependent plasticity in the mouse visual cortex
Genetics; Molecular biology; Neuroscience; Developmental biology
www.cell.com
October 16, 2025 at 2:23 PM
Full study in @cp-iscience.bsky.social : www.cell.com/iscience/ful...