PhysiCell Project.
physicell.bsky.social
PhysiCell Project.
@physicell.bsky.social
Celebrating 10 years in 2025!

Project home at https://physicell.org
This modeling grammar is fully supported in recent releases of PhysiCell including online studios on nanohub and galaxy!

Links to online studios in a moment.

@galaxyproject.bsky.social
July 29, 2025 at 4:04 PM
Congrats on some terrific work!!
April 9, 2025 at 1:45 PM
We're thrilled we're all together on it!
February 13, 2025 at 5:58 PM
I found the evolving pronunciation a bit funny.

Since it's "physics" + "cells", I pronounce it like "Physics" without the "s", followed by cells.

I've found that others pronounce it like "FizzyCell". But who am I to argue??

Come back tomorrow for more fun backstory. :-)
January 16, 2025 at 1:58 PM
We were favoring Physicell3D, but the simpler Physicell stuck. We switched to camel case (PhysiCell) to emphasize the word parts.

By Dec 2014, we were using PhysiCell in proposals and abstracts. In 2015 PhysiCell appeared in talks and @biorxivpreprint.bsky.social:

www.biorxiv.org/content/10.1...
Agent-based simulation of large tumors in 3-D microenvironments
Multicellular simulations of tumor growth in complex 3-D tissues, where data come from high content in vitro and bioengineered experiments, have gained significant attention by the cancer modeling com...
www.biorxiv.org
January 16, 2025 at 1:58 PM
Then we thought through the functionality more

Physicell -- physics-based cell simulator

Or physicells

Physicell3D -- no relevant hits
biophysicell -- meant to sound like biophysical
biophysicells -- biophysics-based cell simulator / biophysics-based cell system
and other variants
January 16, 2025 at 1:58 PM
CATE : cell and tissue environment -- but cate.org is taken

SCATE : simulated cell and tissue environment -- scate.org taken

catde : cell and tissue development environment (but not taken)

But catde wasn't a super appealing name to say.
January 16, 2025 at 1:58 PM
OpenMcSim : open multicellular simulator

abcats - agent based cell and tissue simulator

OpenVCATS - open virtual cell and tissue simulators - agent based cell and tissue simulator

But still too awkward and chunky ...
January 16, 2025 at 1:58 PM
Leaning back towards functional names ...

Multicellular simulation system : McSimSys (abm plus fvm)

And names emphasizing open source (compared to some closed-source binaries in Germany at the time):

OpenBioSims - open source bio simulation system
OpenBAMS! open biological agent model system
January 16, 2025 at 1:58 PM
We worried that zany naming schemes could force us to needlessly contort future projects to fit a theme like backronyms, and they could backfire and make the projects sound like a joke.

We steered back towards simple, functional names that clearly describe what the codes do.
January 16, 2025 at 1:58 PM
And more zany thoughts:

Broth (No witty abbreviation)
Water (No witty abbrevation)
Cream of Cellery (or Mushroom or something)

Some we steered away from because we wanted to make clear that we're not only for cancer modeling.

Others because good luck being the top google hit for water.
January 16, 2025 at 1:58 PM
Other names were a bit zanier:

The overarching project is called SoopCanS: Scalable Object Oriented Programming for Cancer Simulations

It contains the follow "cans":
Cellery: A Cellular Agent Based Model

TumorIC: Tumor Initial Conditions (AKA the snapshot generator)
January 16, 2025 at 1:58 PM
Some of our earlier floated names were a bit chunky but very functional (continued):

Biomechanical Individual Based Simulator (BIBSim)
Biomechanical MultiCellular Simulator

(BMCSim)Reducsion: A REaction DiffUsion ConveCTION (ConveCSION) Finite Volume Method code
January 16, 2025 at 1:58 PM
Some of our earlier floated names were a bit chunky but very functional

CAGEMED: Cellular AGEnt based MEthoD
CabMerlot: Cellular Agent Based Model ....
MultiCellular Systems Simulator (MCSSim)
Mechanical MultiCellular Simulator (MMCSim)
Biomechanical Agent Based Simulator (BiABSim)
January 16, 2025 at 1:58 PM
Moreover, the word "cell" had a lot of collision with the cellular telephony space. Things like CellModel and CellSim were often taken by cellular network projects.
January 16, 2025 at 1:58 PM