Patricia Gerdes
@pgerdes.bsky.social
MSCA Fellow at Lund University 🇪🇺 🇸🇪 | Molecular Neurogenetics lab | retrotransposons, genetics, epigenetics, evolution 🧬 🧠 🐒
Reposted by Patricia Gerdes
How do pluripotent stem cells resist harmful interferon responses to safeguard development? Through total epigenetic lockdown of ligands, sensors and effectors of IFN-I. In our preprint, James Holt shares his PhD discoveries on the ground state of immune evasion 😊: www.biorxiv.org/cgi/content/...
Epigenetic lockdown of type I interferon sensing and signalling in human pluripotent cells.
The Human Silencing Hub (HUSH) complex safeguards genome integrity in human somatic cells by repressing transposable elements and regulating type I interferon (IFN-I) induction. In early development, ...
www.biorxiv.org
October 29, 2025 at 6:03 PM
How do pluripotent stem cells resist harmful interferon responses to safeguard development? Through total epigenetic lockdown of ligands, sensors and effectors of IFN-I. In our preprint, James Holt shares his PhD discoveries on the ground state of immune evasion 😊: www.biorxiv.org/cgi/content/...
Reposted by Patricia Gerdes
Wonderful highlight of our work! 🧬
Hominoid-specific retrotransposons fuel regulatory novelty in early brain development , by @retrogenomics.bsky.social.
➡️ www.cell.com/cell-genomic...
➡️ www.cell.com/cell-genomic...
October 13, 2025 at 6:15 PM
Wonderful highlight of our work! 🧬
Reposted by Patricia Gerdes
New paper from our lab! We found that LINE-1 transposons contribute to early human brain development.
Funded by @asapresearch.parkinsonsroadmap.org
www.cell.com/cell-genomic...
Funded by @asapresearch.parkinsonsroadmap.org
www.cell.com/cell-genomic...
LINE-1 retrotransposons mediate cis-acting transcriptional control in human pluripotent stem cells and regulate early brain development
Adami et al. demonstrate that evolutionarily young L1s are expressed in human pluripotent
stem cells and are dynamically regulated throughout neural differentiation. The study
examines the role of L1s...
www.cell.com
August 23, 2025 at 9:47 AM
New paper from our lab! We found that LINE-1 transposons contribute to early human brain development.
Funded by @asapresearch.parkinsonsroadmap.org
www.cell.com/cell-genomic...
Funded by @asapresearch.parkinsonsroadmap.org
www.cell.com/cell-genomic...
Reposted by Patricia Gerdes
Very happy to share our protocols paper for CELLO-seq. This will make single cell long read RNA-seq more accessible and provides analysis guidelines. We hope this helps the #transposon #TEsky community and folks working on #singleCell isoform and allelic #gene expression. doi.org/10.1038/s415...
Long-read RNA sequencing of transposable elements from single cells using CELLO-seq - Nature Protocols
Single-cell long-read RNA sequencing enables the high-fidelity mapping of single-cell expression data from highly sequence-similar transposable elements to unique genomic loci by correcting errors fro...
doi.org
July 16, 2025 at 4:55 PM
Very happy to share our protocols paper for CELLO-seq. This will make single cell long read RNA-seq more accessible and provides analysis guidelines. We hope this helps the #transposon #TEsky community and folks working on #singleCell isoform and allelic #gene expression. doi.org/10.1038/s415...
Reposted by Patricia Gerdes
Is the annotation of viruses in the human genome accurate? We think not. Take a look at our new paper and let us know if you agree! www.science.org/doi/10.1126/...
A phylogenetic approach uncovers cryptic endogenous retrovirus subfamilies in the primate lineage
A phylogenetic approach reveals cryptic LTR subfamilies and functional insights at nucleotide resolution in primates.
www.science.org
July 21, 2025 at 1:51 PM
Is the annotation of viruses in the human genome accurate? We think not. Take a look at our new paper and let us know if you agree! www.science.org/doi/10.1126/...
Reposted by Patricia Gerdes
Come to Lund! We are looking for a postdoc to join the team. #transposons #epigenetics
April 17, 2025 at 12:29 PM
Come to Lund! We are looking for a postdoc to join the team. #transposons #epigenetics
Reposted by Patricia Gerdes
Join our team as a postdoc and explore the exciting world of transposable elements and developmental biology with us! @imbavienna.bsky.social @vbcscitraining.bsky.social
April 6, 2025 at 4:24 PM
Join our team as a postdoc and explore the exciting world of transposable elements and developmental biology with us! @imbavienna.bsky.social @vbcscitraining.bsky.social
Reposted by Patricia Gerdes
New preprint from our lab! Why is not everyone working on Transposons?
Loss of H3K9me3 maintenance in human neural progenitor cells leads to transcriptional activation of L1 retrotransposons
www.biorxiv.org/content/10.1...
Loss of H3K9me3 maintenance in human neural progenitor cells leads to transcriptional activation of L1 retrotransposons
www.biorxiv.org/content/10.1...
Loss of H3K9me3 maintenance in human neural progenitor cells leads to transcriptional activation of L1 retrotransposons
Heterochromatin is characterised by an inaccessibility to the transcriptional machinery and associated with the histone mark H3K9me3. Heterochromatin erosion is a hallmark of human ageing and H3K9me3 ...
www.biorxiv.org
March 29, 2025 at 10:05 AM
New preprint from our lab! Why is not everyone working on Transposons?
Loss of H3K9me3 maintenance in human neural progenitor cells leads to transcriptional activation of L1 retrotransposons
www.biorxiv.org/content/10.1...
Loss of H3K9me3 maintenance in human neural progenitor cells leads to transcriptional activation of L1 retrotransposons
www.biorxiv.org/content/10.1...
Another successful year with our workshop at #UniStemDay2025. We explained to high school students how we study human brain evolution using human and monkey brain organoids and looking at gene expression 🧠🐒🔬🧬 w/ @vivienhorvath.bsky.social @ofeliakarlsson.bsky.social @lundstem.bsky.social
March 14, 2025 at 2:17 PM
Another successful year with our workshop at #UniStemDay2025. We explained to high school students how we study human brain evolution using human and monkey brain organoids and looking at gene expression 🧠🐒🔬🧬 w/ @vivienhorvath.bsky.social @ofeliakarlsson.bsky.social @lundstem.bsky.social
Reposted by Patricia Gerdes
I am thrilled to share our story online at @cellpress.bsky.social . Big thanks to all authors: Zhiping, Bill, @lubanlab.bsky.social, Keith & bluesky-less!
authors.elsevier.com/c/1kjdaL7PXu...
How to tame a genome invader? It takes wild koalas 🐨🐨 to learn it.
#Retrovirus #koala #piRNA
More below 👇
authors.elsevier.com/c/1kjdaL7PXu...
How to tame a genome invader? It takes wild koalas 🐨🐨 to learn it.
#Retrovirus #koala #piRNA
More below 👇
March 9, 2025 at 2:35 AM
I am thrilled to share our story online at @cellpress.bsky.social . Big thanks to all authors: Zhiping, Bill, @lubanlab.bsky.social, Keith & bluesky-less!
authors.elsevier.com/c/1kjdaL7PXu...
How to tame a genome invader? It takes wild koalas 🐨🐨 to learn it.
#Retrovirus #koala #piRNA
More below 👇
authors.elsevier.com/c/1kjdaL7PXu...
How to tame a genome invader? It takes wild koalas 🐨🐨 to learn it.
#Retrovirus #koala #piRNA
More below 👇
Reposted by Patricia Gerdes
Read this preprint today from @jakobssonlab.bsky.social lab that profiles and CRISPRi perturbs L1 transcription in hiPSCs and cerebral organoids. It is extremely well done. The L1 CRISPRi phenotype in the organoids is subtle and variable but interesting. 1/n
www.biorxiv.org/content/10.1...
#TEsky
www.biorxiv.org/content/10.1...
#TEsky
LINE-1 retrotransposons regulate the exit of human pluripotency and early brain development
Long interspersed nuclear element 1 (L1) retrotransposons represent a vast source of divergent genetic information. However, mechanistic analysis of whether and how L1s contribute to human development...
www.biorxiv.org
February 13, 2025 at 2:18 AM
Read this preprint today from @jakobssonlab.bsky.social lab that profiles and CRISPRi perturbs L1 transcription in hiPSCs and cerebral organoids. It is extremely well done. The L1 CRISPRi phenotype in the organoids is subtle and variable but interesting. 1/n
www.biorxiv.org/content/10.1...
#TEsky
www.biorxiv.org/content/10.1...
#TEsky
Reposted by Patricia Gerdes
We are hiring! 3-year BBSRC-funded postdoc position available. TEs, epigenetics, pregnancy: if you love one or more of these keywords, apply through the link below.
Please spread the word.
Please spread the word.
Postdoctoral Research Associate - QMUL Jobs
ID: 4897. Title: Postdoctoral Research Associate . Application Deadline:
qmul-jobs.tal.net
January 21, 2025 at 9:33 AM
We are hiring! 3-year BBSRC-funded postdoc position available. TEs, epigenetics, pregnancy: if you love one or more of these keywords, apply through the link below.
Please spread the word.
Please spread the word.
Reposted by Patricia Gerdes
We profiled the effects of our CRISPRi system targeting young L1 elements in human pluripotency & brain development. These elements deeply impact our transcriptome, but also have very distinct effects on their nearby genome. Check it out!! 🧬👾
#TEsky #CRISPR #L1 #development #epigenetics
#TEsky #CRISPR #L1 #development #epigenetics
🚨 New pre-print from Team Jakobsson! LINE-1 retrotransposons regulate the exit of human pluripotency and early brain development.
This work was led by @anitaada.bsky.social, @raquelgarza.bsky.social and @jakobssonlab.bsky.social from the Jakobsson Lab.
www.biorxiv.org/content/10.1...
This work was led by @anitaada.bsky.social, @raquelgarza.bsky.social and @jakobssonlab.bsky.social from the Jakobsson Lab.
www.biorxiv.org/content/10.1...
LINE-1 retrotransposons regulate the exit of human pluripotency and early brain development
Long interspersed nuclear element 1 (L1) retrotransposons represent a vast source of divergent genetic information. However, mechanistic analysis of whether and how L1s contribute to human development...
www.biorxiv.org
January 18, 2025 at 11:30 AM
We profiled the effects of our CRISPRi system targeting young L1 elements in human pluripotency & brain development. These elements deeply impact our transcriptome, but also have very distinct effects on their nearby genome. Check it out!! 🧬👾
#TEsky #CRISPR #L1 #development #epigenetics
#TEsky #CRISPR #L1 #development #epigenetics
Reposted by Patricia Gerdes
Profiling and targeting young L1s is no easy matter 🧐 check out our new preprint to see how we delve into transcriptional and epigenomic profiling of L1s, and investigate their involvement in pluripotency and early brain development 🧠
🚨 New pre-print from Team Jakobsson! LINE-1 retrotransposons regulate the exit of human pluripotency and early brain development.
This work was led by @anitaada.bsky.social, @raquelgarza.bsky.social and @jakobssonlab.bsky.social from the Jakobsson Lab.
www.biorxiv.org/content/10.1...
This work was led by @anitaada.bsky.social, @raquelgarza.bsky.social and @jakobssonlab.bsky.social from the Jakobsson Lab.
www.biorxiv.org/content/10.1...
LINE-1 retrotransposons regulate the exit of human pluripotency and early brain development
Long interspersed nuclear element 1 (L1) retrotransposons represent a vast source of divergent genetic information. However, mechanistic analysis of whether and how L1s contribute to human development...
www.biorxiv.org
January 18, 2025 at 2:53 PM
Profiling and targeting young L1s is no easy matter 🧐 check out our new preprint to see how we delve into transcriptional and epigenomic profiling of L1s, and investigate their involvement in pluripotency and early brain development 🧠
Reposted by Patricia Gerdes
🚨 New pre-print from Team Jakobsson! LINE-1 retrotransposons regulate the exit of human pluripotency and early brain development.
This work was led by @anitaada.bsky.social, @raquelgarza.bsky.social and @jakobssonlab.bsky.social from the Jakobsson Lab.
www.biorxiv.org/content/10.1...
This work was led by @anitaada.bsky.social, @raquelgarza.bsky.social and @jakobssonlab.bsky.social from the Jakobsson Lab.
www.biorxiv.org/content/10.1...
LINE-1 retrotransposons regulate the exit of human pluripotency and early brain development
Long interspersed nuclear element 1 (L1) retrotransposons represent a vast source of divergent genetic information. However, mechanistic analysis of whether and how L1s contribute to human development...
www.biorxiv.org
January 18, 2025 at 9:41 AM
🚨 New pre-print from Team Jakobsson! LINE-1 retrotransposons regulate the exit of human pluripotency and early brain development.
This work was led by @anitaada.bsky.social, @raquelgarza.bsky.social and @jakobssonlab.bsky.social from the Jakobsson Lab.
www.biorxiv.org/content/10.1...
This work was led by @anitaada.bsky.social, @raquelgarza.bsky.social and @jakobssonlab.bsky.social from the Jakobsson Lab.
www.biorxiv.org/content/10.1...
Reposted by Patricia Gerdes
New preprint from our lab. Led by the outstanding @anitaada.bsky.social and @raquelgarza.bsky.social. Funded by @asapresearch.bsky.social and @vetenskapsradet.bsky.social.
LINE-1 retrotransposons regulate the exit of human pluripotency and early brain development
www.biorxiv.org/content/10.1...
LINE-1 retrotransposons regulate the exit of human pluripotency and early brain development
www.biorxiv.org/content/10.1...
LINE-1 retrotransposons regulate the exit of human pluripotency and early brain development
Long interspersed nuclear element 1 (L1) retrotransposons represent a vast source of divergent genetic information. However, mechanistic analysis of whether and how L1s contribute to human development...
www.biorxiv.org
January 18, 2025 at 8:58 AM
New preprint from our lab. Led by the outstanding @anitaada.bsky.social and @raquelgarza.bsky.social. Funded by @asapresearch.bsky.social and @vetenskapsradet.bsky.social.
LINE-1 retrotransposons regulate the exit of human pluripotency and early brain development
www.biorxiv.org/content/10.1...
LINE-1 retrotransposons regulate the exit of human pluripotency and early brain development
www.biorxiv.org/content/10.1...
Reposted by Patricia Gerdes
Don't miss the first CSH Asia meeting on transposons in April in Suzhou, China. Truly fantastic line-up! Abstract deadline at the end of the month... (why is not everyone working on transposons?).
January 13, 2025 at 3:18 PM
Don't miss the first CSH Asia meeting on transposons in April in Suzhou, China. Truly fantastic line-up! Abstract deadline at the end of the month... (why is not everyone working on transposons?).
Reposted by Patricia Gerdes
We're thrilled to announce that our project has been funded by @asapresearch.bsky.social in partnership with the Michael J. Fox Foundation! 🚀 Excited to continue exploring the role of transposable elements in Parkinson’s disease. Learn more here:
www.lunduniversity.lu.se/article/52-m...
www.lunduniversity.lu.se/article/52-m...
52 Million SEK towards uncovering genetic drivers of Parkinson’s Disease
Lund University. Jumping genes, or transposable elements, make up nearly half of the human genome. These mobile sequences can shift within the genome and are known to influence various biological proc...
www.lunduniversity.lu.se
December 5, 2024 at 2:45 PM
We're thrilled to announce that our project has been funded by @asapresearch.bsky.social in partnership with the Michael J. Fox Foundation! 🚀 Excited to continue exploring the role of transposable elements in Parkinson’s disease. Learn more here:
www.lunduniversity.lu.se/article/52-m...
www.lunduniversity.lu.se/article/52-m...
Fantastic line up of speakers at the 7th Max Planck Freiburg Epigenetics Meeting! Looking forward to hear about all the interesting science done in the epigenetics field!! 🧬🤓 @mpi-ie.bsky.social
December 4, 2024 at 4:29 PM
Fantastic line up of speakers at the 7th Max Planck Freiburg Epigenetics Meeting! Looking forward to hear about all the interesting science done in the epigenetics field!! 🧬🤓 @mpi-ie.bsky.social
Reposted by Patricia Gerdes
Well done paper from Wenfeng An's lab showing Yy1 activates L1 TF monomers but surprisingly not GF monomers. More monomers = stronger Yy1 activation
academic.oup.com/nar/advance-...
academic.oup.com/nar/advance-...
YY1 is a transcriptional activator of the mouse LINE-1 Tf subfamily
Abstract. Long interspersed element type 1 (LINE-1, L1) is an active autonomous transposable element in human and mouse genomes. L1 transcription is contro
academic.oup.com
November 23, 2024 at 12:06 AM
Well done paper from Wenfeng An's lab showing Yy1 activates L1 TF monomers but surprisingly not GF monomers. More monomers = stronger Yy1 activation
academic.oup.com/nar/advance-...
academic.oup.com/nar/advance-...
Reposted by Patricia Gerdes
The HuSH complex silences retrotransposable elements. We identify HuSH2, centered on TASOR2, targeting KRAB-ZNFs and interferon genes, balancing retrotransposon silencing and immune regulation. www.nature.com/articles/s41...
November 3, 2024 at 3:20 PM
The HuSH complex silences retrotransposable elements. We identify HuSH2, centered on TASOR2, targeting KRAB-ZNFs and interferon genes, balancing retrotransposon silencing and immune regulation. www.nature.com/articles/s41...
Reposted by Patricia Gerdes
🧬 🧠 Excited to see it printed! We bring key insights on the epigenetic regulation of SVAs, including SVA-XDP: a polymorphic SVA driving a rare neurodegenerative disorder
@jakobssonlab.bsky.social @vivienhorvath.bsky.social
#TEworldwide #Transposons #XDP #NSMB
+ the volume has the cutest cover 🦔
@jakobssonlab.bsky.social @vivienhorvath.bsky.social
#TEworldwide #Transposons #XDP #NSMB
+ the volume has the cutest cover 🦔
November 27, 2024 at 4:58 PM
🧬 🧠 Excited to see it printed! We bring key insights on the epigenetic regulation of SVAs, including SVA-XDP: a polymorphic SVA driving a rare neurodegenerative disorder
@jakobssonlab.bsky.social @vivienhorvath.bsky.social
#TEworldwide #Transposons #XDP #NSMB
+ the volume has the cutest cover 🦔
@jakobssonlab.bsky.social @vivienhorvath.bsky.social
#TEworldwide #Transposons #XDP #NSMB
+ the volume has the cutest cover 🦔
Reposted by Patricia Gerdes
If you like #Transposons 👾 check out this feed and tag your posts with #TEsky! Thanks @tobybarilbio.bsky.social 🤗 bsky.app/profile/did:...
November 15, 2024 at 6:58 AM
If you like #Transposons 👾 check out this feed and tag your posts with #TEsky! Thanks @tobybarilbio.bsky.social 🤗 bsky.app/profile/did:...
Reposted by Patricia Gerdes
Thrilled to announce that the EMBO workshop «Mobile Genome» will be back in Heidelberg, Nov 4-7th 2025 @EMBLEvents @EMBO. Registration open soon but you can already register interest. Organized with fantastic colleagues @juliusbrennecke @GonzalezLab_BCN @JoePetersLab
www.embl.org/about/info/c...
www.embl.org/about/info/c...
The mobile genome: genetic and physiological impacts of transposable elements
www.embl.org
November 14, 2024 at 11:27 AM
Thrilled to announce that the EMBO workshop «Mobile Genome» will be back in Heidelberg, Nov 4-7th 2025 @EMBLEvents @EMBO. Registration open soon but you can already register interest. Organized with fantastic colleagues @juliusbrennecke @GonzalezLab_BCN @JoePetersLab
www.embl.org/about/info/c...
www.embl.org/about/info/c...
Reposted by Patricia Gerdes
Bluesky tip for newbies: Bluesky has no real algorithm. Likes here do nothing but show the poster that you enjoyed their content.
That kindness is always going to be appreciated by creators, but if you want to help to boost something here, you have to repost it so others see it. 🙂
That kindness is always going to be appreciated by creators, but if you want to help to boost something here, you have to repost it so others see it. 🙂
November 18, 2024 at 10:27 AM
Bluesky tip for newbies: Bluesky has no real algorithm. Likes here do nothing but show the poster that you enjoyed their content.
That kindness is always going to be appreciated by creators, but if you want to help to boost something here, you have to repost it so others see it. 🙂
That kindness is always going to be appreciated by creators, but if you want to help to boost something here, you have to repost it so others see it. 🙂